1. Date of download: 7/18/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Benefits of Lifestyle Modification in the Pharmacologic Treatment of Obesity: A Randomized Trial Arch Intern Med. 2001;161(2):218-227. doi:10.1001/archinte.161.2.218 Percentage reduction in initial body weight for women treated with sibutramine hydrochloride alone (drug-alone), sibutramine plus group lifestyle modification (drug-plus-lifestyle), and sibutramine and lifestyle modification group (combined treatment), as assessed by a last-observation-carried forward analysis. All 3 groups differed significantly (P<.05 for all) from each other at month 6. At month 12, the 19 women in the drug-alone group lost significantly (P<.05) less weight than women in the other 2 groups (which did not differ significantly from each other). Drug-alone group indicates the participants who received sibutramine treatment alone; drug- plus-lifestyle group, participants who received sibutramine treatment and attended weekly group lifestyle modification sessions for the first 20 weeks; and the combined treatment group, participants who received sibutramine treatment, attended weekly group lifestyle modification sessions for the first 20 weeks, and ate a 4184-kJ/d (1000-kcal/d) diet for the first 16 weeks. For more detailed information see the "Treatment Groups" subsection of the "Participants and Methods" section. Figure Legend:

2. Date of download: 7/18/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Benefits of Lifestyle Modification in the Pharmacologic Treatment of Obesity: A Randomized Trial Arch Intern Med. 2001;161(2):218-227. doi:10.1001/archinte.161.2.218 Expected percentage reduction in initial body weight for women in the 3 groups. Respondents reported the cumulative number of pounds they expected to lose by each period. These values were converted to the percent reduction in initial body weight. Drug- alone group indicates the participants who received sibutramine hydrochloride treatment alone; drug-plus-lifestyle group, participants who received sibutramine treatment and attended weekly group lifestyle modification sessions for the first 20 weeks; and the combined treatment group, participants who received sibutramine treatment, attended weekly group lifestyle modification sessions for the first 20 weeks, and ate a 4184-kJ/d (1000-kcal/d) diet for the first 16 weeks. For more detailed information see the "Treatment Groups" subsection of the "Participants and Methods" section. Figure Legend:

3. Date of download: 7/18/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Benefits of Lifestyle Modification in the Pharmacologic Treatment of Obesity: A Randomized Trial Arch Intern Med. 2001;161(2):218-227. doi:10.1001/archinte.161.2.218 A, Satisfaction with weight loss at months 3, 6, and 12, as reported by women in the 3 groups. B, Satisfaction with changes in physical health and energy levels at months 3, 6, and 12, as reported by women in the 3 groups. C, Satisfaction with changes in appearance at months 3, 6, and 12, as reported by women in the 3 groups. D, Satisfaction with changes in self-esteem at months 3, 6, and 12, as reported by women in the 3 groups. Bars with different lowercased alphabet letters differ significantly (P<.05), as determined by the Tukey honestly significant difference test. Drug-alone group indicates the participants who received sibutramine hydrochloride treatment alone; drug-plus-lifestyle group, participants who received sibutramine treatment and attended weekly group lifestyle modification sessions for the first 20 weeks; and the combined treatment group, participants who received sibutramine treatment, attended weekly group lifestyle modification sessions for the first 20 weeks, and ate a 4184-kJ/d (1000-kcal/d) diet for the first 16 weeks. For more detailed information see the "Treatment Groups" subsection of the "Participants and Methods" section. The extremes of the 10-point scale were as follows: 1, very dissatisfied; 10, very satisfied. Figure Legend:

4. Date of download: 7/18/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Benefits of Lifestyle Modification in the Pharmacologic Treatment of Obesity: A Randomized Trial Arch Intern Med. 2001;161(2):218-227. doi:10.1001/archinte.161.2.218 Satisfaction with weight loss medication (ie, sibutramine hydrochloride) at months 3, 6, and 12, as reported by women in the 3 groups. Women treated with sibutramine alone were significantly (P<.05) less satisfied with the medication at months 6 and 12 than were the participants in the drug-plus-lifestyle group and combined treatment group (which did not differ significantly). (Data were analyzed using the Tukey honestly significant difference test.) Drug-alone group indicates the participants who received sibutramine treatment alone; drug-plus-lifestyle group, participants who received sibutramine treatment and attended weekly group lifestyle modification sessions for the first 20 weeks; and the combined treatment group, participants who received sibutramine treatment, attended weekly group lifestyle modification sessions for the first 20 weeks, and ate a 4184-kJ/d (1000-kcal/d) diet for the first 16 weeks. For more detailed information see the "Treatment Groups" subsection of the "Participants and Methods" section. The extremes of the 10-point scale were as follows: 1, very dissatisfied; 10, very satisfied. Figure Legend: