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SOD2 overexpression: enhanced mitochondrial tolerance but absence of effect on UCP activity by José P Silva, Irina G Shabalina, Eric Dufour, Natasa Petrovic,

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Presentation on theme: "SOD2 overexpression: enhanced mitochondrial tolerance but absence of effect on UCP activity by José P Silva, Irina G Shabalina, Eric Dufour, Natasa Petrovic,"— Presentation transcript:

1 SOD2 overexpression: enhanced mitochondrial tolerance but absence of effect on UCP activity by José P Silva, Irina G Shabalina, Eric Dufour, Natasa Petrovic, Emma C Backlund, Kjell Hultenby, Rolf Wibom, Jan Nedergaard, Barbara Cannon, and Nils ‐ Göran Larsson EMBO J. Volume 24(23):4061-4070 December 7, 2005 ©2005 by European Molecular Biology Organization

2 Creation of SOD2 ‐ overexpressing mice. José P Silva et al. EMBO J. 2005;24:4061-4070 ©2005 by European Molecular Biology Organization

3 Superoxide measurements. José P Silva et al. EMBO J. 2005;24:4061-4070 ©2005 by European Molecular Biology Organization

4 Induction of mitochondrial high ‐ amplitude swelling. José P Silva et al. EMBO J. 2005;24:4061-4070 ©2005 by European Molecular Biology Organization

5 Mitochondrial respiratory measurements. José P Silva et al. EMBO J. 2005;24:4061-4070 ©2005 by European Molecular Biology Organization

6 Regulation of UCP1 activity in brown fat mitochondria. José P Silva et al. EMBO J. 2005;24:4061-4070 ©2005 by European Molecular Biology Organization

7 Effects of SOD2 overexpression on skeletal muscle mitochondria. José P Silva et al. EMBO J. 2005;24:4061-4070 ©2005 by European Molecular Biology Organization

8 Body weights and metabolic rate measurements. José P Silva et al. EMBO J. 2005;24:4061-4070 ©2005 by European Molecular Biology Organization

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