1. Date of download: 6/29/2016 Copyright © 2016 American Medical Association. All rights reserved. From: The Time Course of Topical PUVA Erythema Following 15- and 5-Minute Methoxsalen Immersion Arch Dermatol. 2003;139(3):331-334. doi:10.1001/archderm.139.3.331 Box plot of the visual minimal phototoxic doses (MPDs) at each evaluation time after 15-minute methoxsalen immersion (n = 22). The median lowest MPD occurred at 96, 120, and 144 hours. This was not significant compared with 72 hours. The dark horizontal lines indicate median values; boxes, interquartile ranges; error bars, values adjacent to the interquartile ranges; and circles, outliers. There is no upper error bar at 96 hours because most of the results at 96 hours fell within the interquartile range. Likewise, there is no box at 48 hours because most of the results fell at the median value. Figure Legend:

2. Date of download: 6/29/2016 Copyright © 2016 American Medical Association. All rights reserved. From: The Time Course of Topical PUVA Erythema Following 15- and 5-Minute Methoxsalen Immersion Arch Dermatol. 2003;139(3):331-334. doi:10.1001/archderm.139.3.331 The number of subjects who reached and sustained peak erythema (ie, lowest minimal phototoxic dose) at each evaluation time for 15- and 5-minute methoxsalen immersion. For 15-minute immersion, most subjects were at peak response at 120 hours; for 5- minute immersion, they were at peak response between 96 and 144 hours. Figure Legend:

3. Date of download: 6/29/2016 Copyright © 2016 American Medical Association. All rights reserved. From: The Time Course of Topical PUVA Erythema Following 15- and 5-Minute Methoxsalen Immersion Arch Dermatol. 2003;139(3):331-334. doi:10.1001/archderm.139.3.331 Box plot summarizing the results of D 0.025 evaluation (measurement of the dose of UV-A radiation required to cause an increase in the erythema index of 0.025) (n = 18) for 15-minute methoxsalen immersion. The dark horizontal lines indicate median values; boxes, interquartile ranges; error bars, values adjacent to the interquartile ranges; and the asterisk at 120 hours, the D 0.025 was significantly lower at 120 than at 72 hours (P =.03). Figure Legend:

4. Date of download: 6/29/2016 Copyright © 2016 American Medical Association. All rights reserved. From: The Time Course of Topical PUVA Erythema Following 15- and 5-Minute Methoxsalen Immersion Arch Dermatol. 2003;139(3):331-334. doi:10.1001/archderm.139.3.331 Minimal phototoxic doses (MPDs) as assessed visually in 13 subjects at each evaluation time after 5-minute methoxsalen immersion. Broad peak was demonstrable from 72 to 168 hours. The dark horizontal lines indicate median values; boxes, interquartile ranges; error bars, values adjacent to the interquartile ranges; and circles, outliers. There is no upper error bar at 24 hours because most of the results at 24 hours fell within the interquartile range. Figure Legend:

5. Date of download: 6/29/2016 Copyright © 2016 American Medical Association. All rights reserved. From: The Time Course of Topical PUVA Erythema Following 15- and 5-Minute Methoxsalen Immersion Arch Dermatol. 2003;139(3):331-334. doi:10.1001/archderm.139.3.331 Intra-individual comparison of the mean erythema summation scores after 15- and 5-minute methoxsalen immersions (n = 13). The scores were significantly lower for 5-minute immersion at all time points (P<.01). Figure Legend: