1. Date of download: 6/24/2016 From: Comparative Effectiveness and Safety of Methods of Insulin Delivery and Glucose Monitoring for Diabetes Mellitus: A Systematic Review and Meta-analysis Ann Intern Med. 2012;157(5):336-347. doi:10.7326/0003-4819-157-5-201209040-00508 Summary of evidence search and selection. CENTRAL= Cochrane Central Register of Controlled Trials; CSII = continuous subcutaneous insulin infusion; HbA 1c = hemoglobin A 1c ; MDI = multiple daily injections; rt-CGM = real-time continuous glucose monitoring; SMBG = self-monitoring of blood glucose; T1DM = type 1 diabetes mellitus; T2DM = type 2 diabetes mellitus. * Total number of articles may exceed the number in the corresponding box because articles could be excluded for more than 1 reason. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

2. Date of download: 6/24/2016 From: Comparative Effectiveness and Safety of Methods of Insulin Delivery and Glucose Monitoring for Diabetes Mellitus: A Systematic Review and Meta-analysis Ann Intern Med. 2012;157(5):336-347. doi:10.7326/0003-4819-157-5-201209040-00508 Mean between-group difference in the change from baseline HbA 1c comparing CSII with MDI among children and adolescents with T1DM, adults with T1DM, and adults with T2DM. Error bars represent 95% CIs. Shaded boxes represent individual study point estimates. Box size corresponds to weight of study. CSII = continuous subcutaneous insulin infusion; HbA 1c = hemoglobin A 1c ; MDI = multiple daily injections; T1DM = type 1 diabetes mellitus; T2DM = type 2 diabetes mellitus. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

3. Date of download: 6/24/2016 From: Comparative Effectiveness and Safety of Methods of Insulin Delivery and Glucose Monitoring for Diabetes Mellitus: A Systematic Review and Meta-analysis Ann Intern Med. 2012;157(5):336-347. doi:10.7326/0003-4819-157-5-201209040-00508 Pooled IRR for severe hypoglycemia comparing CSII with MDI among children and adolescents with T1DM. Error bars represent 95% CIs. Shaded boxes represent individual study point estimates. Box size corresponds to weight of study. CSII = continuous subcutaneous insulin infusion; IRR = incidence rate ratio; MDI = multiple daily injections; T1DM = type 1 diabetes mellitus. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

4. Date of download: 6/24/2016 From: Comparative Effectiveness and Safety of Methods of Insulin Delivery and Glucose Monitoring for Diabetes Mellitus: A Systematic Review and Meta-analysis Ann Intern Med. 2012;157(5):336-347. doi:10.7326/0003-4819-157-5-201209040-00508 Pooled OR for severe hypoglycemia comparing CSII with MDI among adults with T1DM. Error bars represent 95% CIs. Shaded boxes represent individual study point estimates. Box size corresponds to weight of study. CSII = continuous subcutaneous insulin infusion; MDI = multiple daily injections; OR = odds ratio; T1DM = type 1 diabetes mellitus. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

5. Date of download: 6/24/2016 From: Comparative Effectiveness and Safety of Methods of Insulin Delivery and Glucose Monitoring for Diabetes Mellitus: A Systematic Review and Meta-analysis Ann Intern Med. 2012;157(5):336-347. doi:10.7326/0003-4819-157-5-201209040-00508 Comparison of rt-CGM with SMBG and SAP use with MDI plus SMBG among patients with T1DM. Mean between-group difference in the change from baseline HbA 1c among patients with T1DM comparing rt-CGM with SMBG and SAP with MDI plus SMBG (top). Pooled OR of severe hypoglycemia comparing rt-CGM with SMBG among patients with T1DM (bottom). Error bars represent 95% CIs. Shaded boxes represent individual study point estimates. Box size corresponds to weight of study. HbA 1c = hemoglobin A 1c ; MDI = multiple daily injections; OR = odds ratio; rt-CGM = real-time continuous glucose monitoring; SAP = sensor-augmented pump for insulin delivery; SMBG = self-monitoring of blood glucose; T1DM = type 1 diabetes mellitus. * Patients aged 15–24 y. † Patients aged 8–14 y. ‡ Patients aged >25 y. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

6. Date of download: 6/24/2016 From: Comparative Effectiveness and Safety of Methods of Insulin Delivery and Glucose Monitoring for Diabetes Mellitus: A Systematic Review and Meta-analysis Ann Intern Med. 2012;157(5):336-347. doi:10.7326/0003-4819-157-5-201209040-00508 Adherence with sensor use and mean between-group difference between rt-CGM and SMBG in HbA 1c changed from baseline. HbA 1c = hemoglobin A 1c ; rt-CGM = real-time continuous glucose monitoring; SMBG = self-monitoring of blood glucose. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

7. Date of download: 6/24/2016 From: Comparative Effectiveness and Safety of Methods of Insulin Delivery and Glucose Monitoring for Diabetes Mellitus: A Systematic Review and Meta-analysis Ann Intern Med. 2012;157(5):336-347. doi:10.7326/0003-4819-157-5-201209040-00508 Between-group difference between rt-CGM and SMBG in time spent in hypoglycemic range changed from baseline among patients with T1DM. Boxes indicate individual study point estimates. The box size denotes the weight of the study, with larger boxes contributing more to the pooled estimate. The width of the horizontal lines represents the 95% CI for each study. The diamond at the bottom of the figure indicates the 95% CI for the random-effects pooled estimate. Test for heterogeneity: Q = 4.24 (P = 0.52). rt-CGM = real-time continuous glucose monitoring; SMBG = self- monitoring of blood glucose; T1DM = type 1 diabetes mellitus. * Patients aged >25 y. † Patients aged 8–14 y. ‡ Patients aged 15–24 y. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

8. Date of download: 6/24/2016 From: Comparative Effectiveness and Safety of Methods of Insulin Delivery and Glucose Monitoring for Diabetes Mellitus: A Systematic Review and Meta-analysis Ann Intern Med. 2012;157(5):336-347. doi:10.7326/0003-4819-157-5-201209040-00508 Between-group difference between rt-CGM and SMBG in time spent in hyperglycemic range changed from baseline among patients with T1DM. Boxes indicate individual study point estimates. The box size denotes the weight of the study, with larger boxes contributing more to the pooled estimate. The width of the horizontal lines represents the 95% CI for each study. The diamond at the bottom of the figure indicates the 95% CI for the random-effects pooled estimate. Test for heterogeneity: Q = 5.80 (P = 0.33). rt-CGM = real-time continuous glucose monitoring; SMBG = self- monitoring of blood glucose; T1DM = type 1 diabetes mellitus. * Patients aged >25 y. † Patients aged 8–14 y. ‡ Patients aged 15–24 y. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians