1. Pregnancy associated breast cancer (PABC)
Lilla Madaras
2nd Department of Pathology
Semmelweis University
Budapest, Hungary
4th Pannonia Congress of Pathology, Osijek, Croatia
May

2. Definition
Breast cancer during pregnancy or within a year after its cessation

3. Incidence 0,6% of breast cancer cases are pregnancy related
1/ /3000 pregnancies
Incidence of PABC increasing since women tend to postpone childbearing to later age

4. Major clinical issues
Rare disease, complex situation- not enough experience with treatment of PABC
Delayed diagnosis?
Imaging difficult- young, dense breast altered by pregnancy related hormonal changes
Treatment may potentially harm the fetus
Induced abortion, preterm delivery

5. Disease biology
Pathological features of PABC don't differ significantly from that of early-onset non-PABC
Mainly TNBC and LuminalB tumors
Role of tumor microenvironment

6. Treatment Treatment during the second and third trimester
Current treatment principle is to treat patients with PABC as close to non-PABC patients as possible
Pregnancy is considered as of high risk- regular fetal monitoring
Long term follow up of individuals with prenatal chemotherapy

7. Prognosis Conflicting data about prognosis
Worse outcome (compared to that of young women with non-PABC) according to some studies