1. HADRONTHERAPY IN ROMANIA NICOLAE IOAN VERGA M.D., Ph.D., D.Sc. “CAROL DAVILA” UNIVERSITY OF MEDICINE AND PHARMACY, ROMANIAN SOCIETY OF HADRONTHERAPY BUCHAREST, ROMANIA HADRONTHÉRAPIE EN ROUMANIE LYON HADRONTHERAPY WORKSHOP 20-21 July 06

2. – For 300.000 Romanian cases of cancer, the existent radiotherapies facilities of national oncology system are inadequate. – The recommendations of AEIA about the country necessity planning of radiotherapy are in direct proportions with the national inhabitant revenue and the number of people. – Incorrect because this kind of plan offer an open door for the actual chemotherapy and surgery, the treatment tools reputable for their high costs and low efficacy. LYON HADRONTHERAPY WORKSHOP 20-21 July 06

3. – For a cancer patient it is preferable to make many efficient therapeutically acts in a short time with a low human costs, therapy followed by the diagnostic for evaluation of present state and a prognostic evolution. – This is a correct medical, scientifically and humanitarian point of view and the hadrontherapy is solution, now and after ten years when the number of cancer cases will be double. – This high costs means financials and human (biologically, psychically and social ) costs difficulty supportable by an economic system destructed like these from my country. – We are too poor to buy the cheap things ! LYON HADRONTHERAPY WORKSHOP 20-21 July 06

4. Ours first results  We have only 4(four !) patients traits with protontherapy. Now, one is dead, two make recurrences and one has a good evolution ! LYON HADRONTHERAPY WORKSHOP 20-21 July 06

5. In this situation we are beginning to make a professional and scientifically organization, named Romanian Society of Hadrontherapy [RSH]. We are medical doctors, physicists, radiobiology specialists and our target is to develop Hadrontherapy in our country. LYON HADRONTHERAPY WORKSHOP 20-21 July 06

6. We started our work with signaling our presence into mass media, to make clinical audits in different specialties, to make of feasibility studies for hadrontherapy facilities. In this year we hope to organize the first consultative workshop in the field of hadrontherapy. LYON HADRONTHERAPY WORKSHOP 20-21 July 06

7. Another important direction is to assure the economic bases of our activities and our economists work for planning a good strategy for this. LYON HADRONTHERAPY WORKSHOP 20-21 July 06

8. Another objective of medical department of RSH is to select the patients with indications for hadrontherapy, to contact the hadrontherapy centers and to suggest our Minister of Health and our National House of Health Insurance the best possibilities to treat the patients, to make a good follow-up, and to evaluate the efficiency of their treatment. LYON HADRONTHERAPY WORKSHOP 20-21 July 06

9. Our research  National  International LYON HADRONTHERAPY WORKSHOP 20-21 July 06

10. National  Our national actual facilities are resumed to be a support for the international research collaborations.  But, step by step, we organize the studies in some phenomena of fragmentation, the theoretically studies for simulation, for building the computational biology and theoretical medicine models, studies in neutrotherapy. LYON HADRONTHERAPY WORKSHOP 20-21 July 06

11. International We began at Dubna : Protontherapy MedNuclotron Program. In MedNuclotron we have two groups: -one in radiobiology in space (Romanian Space Research Institute) -another in radiotherapy with protons and carbon ions -University of Medicine and Pharmacy, -INCDIE ICPE-CA, -IFIN “HH”. LYON HADRONTHERAPY WORKSHOP 20-21 July 06

12. The objectives of the second group are - the spatial and temporal dosimetry of the tissue irradiation in the neighboring of the target tissue (neurons, protons another nuclear fragments and the gamma irradiations) - the supplemental irradiation of the target and the rest of human body, after the exposure of protons or carbon ions beams - the radiobiological and radio electro biological effects after hadrontherapy - specific detectors, equipment and dosimetricaly methods - computational biology and theoretically medicine models - some clinically audit, comparison and association between protontherapy, ions carbons, electromagnetic radiotherapy - study of centralized hadrontherapy (based to synchrotron or Fixed Field Alternating Gradient synchrotron) or distributed hadrontherapy (based to little superconducting cyclotron or new sources of hadron beams) - the PET and BNCT studies LYON HADRONTHERAPY WORKSHOP 20-21 July 06

13. The collaboration needs and opportunities  - economically problems of hadrontherapy  o feasibility studies  o protocols of collaboration in the treatment of our patients - the research collaborations or multi- centers research o- technological collaborations o- theoretically and computing fields o- medical, radiobiological research LYON HADRONTHERAPY WORKSHOP 20-21 July 06

14. The proposed instruments of collaboration :  - workshops,  - common participating in research programs,  - contracts of technology transfer, technology acquisitions, etc.  - learning programs and exchange experience for the specialists, etc. LYON HADRONTHERAPY WORKSHOP 20-21 July 06

15. The Romanian institutions interested are:  University of Medicine and Pharmacy  Romanian Society of Hadrontherapy  National Institutes with interests in nuclear, electromagnetic, biology, research (ICDIE ICPE-CA, IFIN “HH”, IBC, etc.)  Private Romanian companies LYON HADRONTHERAPY WORKSHOP 20-21 July 06