1. The Nervous System

2. Overall Function –COMMUNICATION –Works with the endocrine system in regulating body functioning, but the nervous system is specialized for SPEED

3. Neurons A neuron is the functional unit of the nervous system Neurons are specialized for transmitting signals from one location in the body to another Neurons consist of a large cell body (contain a nucleus and other organelles), and neuronal processes –Axons Conduct messages AWAY from cell body –Dendrites Conducts messages TOWARD cell body

4. Neuron Structure

5. Communication Lines Stimulus (input) Receptors (sensory neurons) Integrators (interneurons) motor neurons Effectors (muscles, glands) Response (output) Figure 34.1 Page 579

6. Major Nervous System Processes Input –The conduction of signals from sensory receptors to integration centers in the nervous system Integration –The process by which the information from the environmental stimulation of the sensory receptors is interpreted and associated with appropriate responses of the body Motor Output –The conduction of signals from the processing center to the muscle cells or gland cells that actually carry out the body’s responses to stimuli

7. Central and Peripheral Nervous Systems The central nervous system consists of the brain and spinal cord –This is where integration occurs –Made of interneurons The peripheral nervous system consists of the nerve cells that communicate signals between the CNS and the rest of the body –Sensory neurons Carry info from the sensory receptors to the brain –Motor neurons Carry info from the brain to effector cells (to do whatever the brain said!)

8. Action Potentials In order to actually TRANSMIT a signal, the voltage (charge) across the membrane has to change –A signal will cause the ion channels to open, letting some of the ions (Na+, K+) through, trying to achieve EQUILIBRIUM –This depolarizes the membrane This causes the signal to be passed along the neuron, which is known as an ACTION POTENTIAL (like a wave of electricity)

9. Action Potentials Action potentials are either ALL or NONE –Either there is enough change in the voltage to pass the message along, or there isn’t –The neuron either “fires” or it doesn’t fire –If your hand is on a 100˚C stove, the action potentials aren’t STRONGER than if you were on a 50˚C stove; they just happen MORE OFTEN

10. Structure of a Neuron dendrites cell body TRIGGER ZONE INPUT ZONE CONDUCTING ZONE OUPUT ZONE axon axon endings Figure 34.2 Page 580

11. Resting Potential Charge difference across the plasma membrane of a neuron Fluid just outside cell is more positively charged than fluid inside because of larged negatively charged proteins in the cytoplasm Potassium (K + ): Higher inside than outside Sodium (Na + ): Higher outside than inside Potential is measured in millivolts Resting potential is usually about -70mv

12. Action Potential A transitory reversal in membrane potential Voltage change causes voltage-gated channels in the membrane to open Na + leaks in (depolarization): Inside of neuron briefly becomes more positive than outside K + leaks out (repolarization): Inside goes back to being negatively charged compared to outside. Na + / K + pumps the Na + and K + back to original positions (refractory period)

13. Action Potential Na + K+K+ K+K+ K+K+ K+K+ K+K+ K+K+ K+K+ 12 34 Figure 34.5d Page 583

14. All or Nothing All action potentials are the same size If stimulation is below threshold level, no action potential occurs If it is above threshold level, cell is always depolarized to the same level

15. Recording of Action Potential action potential threshold resting membrane potential Time (milliseconds) Membrane potential (millivolts) -40 -70 -20 0 +20 0 1 23 4 5 Figure 34.6b Page 583

16. Chemical Synapse Gap between axon of one neuron and dendrite of adjacent neuron Action potential in axon ending of presynaptic cell causes voltage-gated calcium channels to open Flow of calcium into presynaptic cell causes release of neurotransmitter into synaptic cleft synaptic vesicle plasma membrane of axon ending of presynapic cell plasma membrane of postsynapic cell synaptic cleft membrane receptor Figure 34.7a Page 584

17. Neurotransmitters Neurotransmitters are substances that carry the “message” across the synapse Important neurotransmitters: –Acetylcholine (bridges gaps between motor neurons & muscle cells), –norepinephrine, dopamine, serotonin work in CNS

18. Synaptic Transmission Neurotransmitter diffuses across cleft and binds to receptors on membrane of postsynaptic cell Binding of neurotransmitter to receptors opens ion channels in the membrane of postsynaptic cell

19. Ion Gates Open ions neurotransmitter receptor for neurotransmitter gated channel protein Figure 34.7c Page 584

20. Synaptic Transmission Enzymes in synaptic cleft will degrade neurotransmitters after action potential is initiated on the post-synaptic cell. The neurotransmitters are recycled after they are broken down. Example: Acetylcholine is broken down by the enzyme cholinesterase

21. Nerve A bundle of axons enclosed within a connective tissue sheath Figure 34.10 Page 586 axon myelin sheath nerve fascicle

22. Myelin Sheath A series of Schwann cells Sheath blocks ion movements Action potential must “jump” from node to node; CREATES RAPID MOVEMENT OF ELECTRICAL IMPULSE Figure 34.11a Page 586

23. Multiple Sclerosis A condition in which nerve fibers lose their myelin Slows conduction Symptoms include visual problems, numbness, muscle weakness, and fatigue

24. Reflexes Automatic movements made in response to stimuli In the simplest reflex arcs, sensory neurons synapse directly on motor neurons; interneurons in CNS aren’t involved. Most reflexes involve an interneuron

25. Stretch Reflex STIMULUS Biceps stretches. Response Biceps contracts. Figure 34.12b Page 587 motor neuron sensory neuron

26. Central and Peripheral Nervous Systems Central nervous system (CNS) –Brain –Spinal cord Peripheral nervous system –Nerves that thread through the body

27. Peripheral Nervous System Somatic nerves –Controls skeletal muscle (voluntary) –(Shown in green) Autonomic nerves _ Controls certain organs, smooth muscle & cardiac muscle (involuntary) –(Shown in red) Figure 34.17 Page 591

28. Two Divisions of Autonomic Nervous System Sympathetic : “speeds up” heart, breathing, release of sugar into blood; fight or flight response Parasympathetic: slows heart, breathing rate; causes secretion of digestive enzymes, etc. Most organs receive input from both Usually have opposite effects on organ

29. Structure of the Spinal Cord spinal cord ganglion nerve vertebra meninges (protective coverings) Figure 34.19a Page 593

30. Divisions of Brain DivisionMain Parts Forebrain Midbrain Hindbrain Cerebrum Olfactory lobes Thalamus Hypothalamus Limbic system Pituitary gland Pineal gland Tectum Pons Cerebellum Medulla oblongata anterior end of the spiral cord Figure 34.20 Page 594

31. Cerebrospinal Fluid Surrounds the spinal cord Fills ventricles within the brain Blood-brain barrier controls which solutes enter the cerebrospinal fluid Figure 34.22 Page 595

32. Anatomy of the Cerebrum Largest and most complex part of human brain (Responsible for thinking & higher level functions) Outer layer (cerebral cortex) is highly folded A longitudinal fissure divides cerebrum into left and right hemispheres Corpus collosum connects the two hemispheres

33. Lobes of the Cerebrum Temporal Frontal Parietal Occipital Primary motor cortex Primary somatosensory cortex Figure 34.25a Page 597

34. Limbic System Controls emotions and has role in memory (olfactory tract)cingulate gyrusthalamus amygdala hippocampus hypothalamus Figure 34.36 Page 597

35. Other Parts of the Brain Cerebellum - Controls muscle coordination and posture Medulla oblongata- Controls heart rate & breathing rate

36. Variations in Nervous Systems Among Animals