2. UCSF ranks #2 in NIH funding and #7 in NCI funding Largest NCI designated CCC in CA #8 ranking in cancer care in US News & World Report 400 members and association members 6000 new cancer patients annually 6 disease site and 5 cross cutting programs 2 SPOREs (breast, brain) UCSF Helen Diller Family Comprehensive Cancer Center

3. Helen Diller Family Cancer Research Building China Basin Genentech Hall QB3 Community Center Rock Hall New Hospital China Basin Mt Zion VA Parnassus Heights SFGH

5. 2340 Sutter Street Cancer Research Building

6. Parnassus Campus

13. Full Research Programs Breast Oncology Joe Gray Laura Esserman Cancer and ImmunityLewis LanierJoel Palefsky Cancer GeneticsAllan BalmainJohn Witte Cell Cycling and SignalingDavid ToczyskiThea Tlsty Hematopoietic MalignanciesKevin ShannonNeal Shah Neurologic OncologyMitch BergerMike Prados Pancreas CancerMargaret TemperoMartin McMahon Pediatric MalignanciesKate MatthayBill Weiss Prostate CancerEric SmallMarc Shuman Diversity and DisparitiesRena PasickLarry Green Tobacco ControlStan GlantzSharon Hall Developing Programs Thoracic OncologyDavid Jablons GYN OncologyJohn Chan Head and Neck CancerDavid Eisele MelanomaBoris Bastian

14. Recent Recognition and National Leadership Institute of Medicine: Dr Abbas Dr Giacomini Dr Glantz Dr Greern Dr Marks Dr McCormick Dr Weiss Dr Werb Dr Yamamoto President of ASCO: Dr Tempero (2003) President of ASPO: Dr Hiatt (2003) President of American Pain Society:Dr Miaskowski (2002) Nobel PrizeDr Blackburn Landon AACR Prize: Dr Blackburn (with Dr Rowley) AACR Gertrude B Elion Award: Dr Coussens AACR-Clowes Award: Dr McCormick Albert Lasker Award: Dr Blackburn Peter Gruber Genetics Prize: Dr Blackburn Samuel Rosenthal Award: Dr Shannon Public Health Programs Award: Dr Pasick SPORE Investigator of the Year: Dr Esserman

15. Mechanisms

16. Responses to Targeted Therapies

17. Population sciences: Risk factors

18. Population Sciences: Policy

19. 10 year budget Investigational Therapeutics$18 million Recruitment$10 million Clinical care and services $6 million Prostate Cancer $5 million Bioinformatics development $4 million Survivorship $2 million

20. Investigational Therapeutics Initiative (Dr Eric Small) Increase the number and quality of investigator-initiated clinical trials Enlarge portfolio of Phase I trials Build an early phase drug testing unit, across all sites, with standard procedures for bio-specimen collection, biomarker analysis, genotyping, PK/PD and imaging Standardize bio-informatics and monitoring across all sites Invest additional $2 million/yr in expansion of CRO to allow accelerated protocol development further centralization of support full implementation of data safety and monitoring plan improved training and credentialing of personnel development of specialized education unit for junior faculty