1. Eating behaviour

2. You will be able to: Understand the role of neural mechanisms involved in controlling eating and satiation Evaluate research into the mechanisms of eating and satiation

3. Discuss neural mechanisms involved in the control of eating behaviour. (8 marks + 16 marks)

4. Eating behaviour covers all aspects of normal eating behaviour and eating disorders. However candidates are likely to focus on hypothalamic feeding and satiety centres and the dual centre model of feeding regulation. This model also involves the role of hormones such as CCK, leptin and ghrelin. As long as the role of hormones is explicitly linked to neural mechanisms in the brain this approach is fully acceptable. Descriptive terms such as ‘neurotransmitter’ would also be sufficient as a link to neural mechanisms eg in relation to neuropeptide Y and serotonin. Answers that focus, for instance, on eating disorders, should be assessed on the degree to which neural (brain) mechanisms are involved. There are no partial performance criteria on this question. It is hard to imagine an answer considering a single mechanism, but any such answer would be limited and unlikely to move beyond Basic.

5. The biology of eating behaviour is very complicated. You need a basic knowledge of the need for control of food intake and body weight, and some of the key processes involved. Focus = The key centres in the hypothalamus need signals to tell them when to start and when to stop feeding. You should be able to outline at least two of these signals.

6. Hetherington and Ranson (1942) Lesions in the hypothalamus of the brain in rats caused the rats to overeat and become obese.

7. The lesion was in the ventromedial nucleus of the hypothalamus and the rat became known as The VMH rat.

8. Found that a lesion in the lateral hypothalamus (LH) led to a loss of feeding in rats known as Aphagia They assumed the function of the LH was to stimulate feeding in hungry rats.

9. The lesion destroyed a vital centre for the control of feeding behaviour. Its destruction led to an increase in feeding and body weight. Hetherington and Ranson assumed this was a ‘satiety centre’. They assumed it was normally activated when the animal was full and its function was to inhibit feeding.

10. Later studies confirmed previous findings. Rise in glucose, decrease in ghrelin release VMH satiety centre activated Satiety, feeding stops Signals of declining nutrient levels, decrease in blood sugar, increase in ghrelin release Lateral hypohtalamus (LH) feeding centre activated Hunger – feeding starts

11. The dual model is confirmed by much research but the pathways are very complex.

13. In Western countries we usually eat to a schedule. The digestive system starts preparing itself by releasing saliva and enzymes just before a meal time (Pinel, 2007). This represents a learned response, anticipating the presence of food.

15. Even when we’re not really hungry, we can be tempted by some things.

16. The empty stomach sends signals to the brain to start eating. An important role is played by a hormone – Grehlin

17. Ghrelin is a hormone that signals the hypothalamus to stimulate feeding. The amount released is directly proportional to the emptiness of the stomach. As the time from the last meal increases so ghrelin secretion is increased.

18. Injections of ghrelin increase food intake and body weight in animals and humans (Cummings, 2006). Gastric bands used to treat obesity reduce ghrelin secretion from the stomach.

19. Cummings (2006) found that ghrelin acts directly on the brain mechanisms of feeding behaviour, including the hypothalamus.

20. Investigated changes in blood ghrelin levels over time between meals. 6 participants ate lunch. Their ghrelin levels were measured from blood samples taken every 5 minutes until they requested their evening meal.

21. Participants assessed their hunger every 30 minutes.

22. Ghrelin levels fell immediately after eating lunch The lowest level was after about 70 minutes. Then they slowly began to rise Peaking as participants requested their evening meal.

23. Ghrelin levels positively correlated with the degree of hunger reported in 5 out of the 6 participants. Conclusion – ghrelin levels directly reflect stomach emptiness and are closely related to feelings of hunger.

24. This supports a role for ghrelin in signalling appetite in humans.

25. Leptin is a hormone released from fatty (adipose) tissue. It acts as an indicator of body weight to hypothalamic mechanisms controlling long-term food intake.