1. TLS CORE with Chromium, White Kidney Bean & Lepticore®

2. State of the Industry: Weight Management The retail sales for Weight Management in the United Kingdom grew from £124.8 million in 2014 to £127.4 million in 2015 Over the last 5 years sales for Weight Loss Supplements have increased by 5.1% The sales for Herbal/ Traditional Dietary Supplements has also increased from £110.1 million in 2010 to £119.2 million in 2015 This indicates a massive potential for profit since this market is consistently growing at a rapid rate. Source: Euromonitor International. “Weight Management in the United Kingdom” 23 Nov 2015

3. State of the Industry: Lepticore® & White Kidney Bean in the Media

4. Why is Lepticore® Important? LeptiCore® is an all-natural ingredient specifically designed to promote healthy weight management. It offers a novel approach to supporting normal metabolic function: Targeting Leptin Sensitivity o Leptin insensitive individuals may have struggled to lose weight in the past, as it is overlooked by most “Fad Diets”

5. White kidney bean extract can assist with slowing down carbohydrate intake o Carbohydrates can elevate blood sugar levels and increase insulin, which causes the body to store fat Both Leptin and Insulin, outside of optimal range, can trigger you to gain extra weight Why is White Kidney Bean Extract Important?

6. The Role of Leptin & Insulin Chronic high sugar and saturated fat consumption leads to a rise in insulin, flooding receptors with insulin and causing them to “push back” or resist. Ironically, insulin resistance signals the body to produce more insulin which triggers more fat storage from the excess kilojoules and prevents fat burning.

7. The Importance of Leptin Regulates energy consumption and expenditure o Reduces appetite o Increases fat burning o Reduces food intake, increase energy expenditure and regulates glucose metabolism Secreted primarily by white adipose tissue (fat cells) Adequate fat store = release leptin = decrease food intake and increase energy utilisation

8. Featuring TLS CORE with Chromium, White Kidney Bean & Lepticore® SUPPORT NORMAL MACRONUTRIENT METABOLISM PROMOTE NORMAL BLOOD GLUCOSE LEVELS CONTRIBUTES TO HEALTHY WEIGHT MANAGEMENT

9. TLS CORE: Ingredients LeptiCore® White Kidney Bean Extract Chromium Vitamin A Bitter Melon Fruit Extract

10. TLS CORE: Ingredients LeptiCore® LeptiCore is a proprietary complex of plant-based polysaccharides. The polysaccharides include guar gum, gum Arabic, and locust bean gum, esterified fatty acids, pomegranate extract, beta-carotene, and blue- green algae. This blend may help support overall health and well-being.

11. TLS CORE: Ingredients White Kidney Bean Extract Phaseolus vulgaris, or white kidney bean, is known as an amylase inhibitor. Amylase is an enzyme that breaks down starchy carbohydrates into more easily absorbed sugars such as glucose. Supplementation with white kidney bean extract allows certain carbohydrates to pass through the body undigested, stopping them from eventually being converted into fat.

12. TLS CORE: Ingredients Chromium Dietary chromium is an essential trace mineral assisting in the metabolism and use of carbohydrates and fat. Known as the glucose tolerance factor, chromium promotes the delivery of blood sugar to cells, thereby helping to maintain normal blood glucose levels. Due to the role it plays in metabolism, chromium is commonly added to natural weight management products.

13. TLS CORE: Ingredients Vitamin A Vitamin A is a fat-soluble vitamin. Sources of vitamin A include organ meats, egg yolks, butter, carrot juice, squash, sweet potatoes, spinach, peaches, fortified dairy products and cod liver oil. Vitamin A is part of a family of compounds including retinol, retinal and beta-carotene. Vitamin A helps to promote normal vision, contributes to normal iron metabolism, contributes to the normal function of the immune system, and has a role in the process of cell specialisation.

14. TLS CORE: Ingredients Bitter Melon Fruit Extract Bitter melon (Momordica charantia) grows in tropical areas and is cultivated throughout South America as a food and folk medicine. It has been shown to have antioxidant and immune-supporting properties. Bitter melon contains several natural plant constituents including alkaloids, glycosides, peptides, cucurbitins, charantin, cucurbitacins, momordine, and momorcharins.

15. Benefits of TLS CORE Ingredients Primary Benefits of TLS CORE with Chromium, White Kidney Bean & LeptiCore®: Contains key proven herbals like White Kidney Bean & LeptiCore® Contains chromium which supports normal macronutrient metabolism Chromium also contributes to the maintenance of normal blood glucose levels Promotes normal iron metabolism with vitamin A Vitamin A contributes to the normal function of the immune system Vitamin A has a role in the process of cell specialisation Contributes to achieving healthy weight management goals

16. What Makes TLS CORE Unique? Compared to most supplements on the market, TLS CORE is specially formulated with vitamin A, chromium and plant based ingredients like White Kidney Bean and a special LeptiCore® Blend to help with your weight management goals. Chromium contributes to normal macronutrient metabolism and the maintenance of normal blood glucose levels. Achieve your weight management goals and get back on the path to health and wellness with TLS CORE!

17. Competitive Supplements TLS CORE provides the best combination of herbals and nutrients in precise dosages recommended by science. Other products may contain select ingredients in lower dosages, but with TLS CORE it’s guaranteed that you are receiving a quality herbal supplement to support healthy weight management and more.

18. Supports need for B-Vitamins in a vegetarian diet Contributes to normal energy-yielding metabolism Contributes to the normal function of the nervous system Contributes to normal psychological functions For best results take it with TLS CORE + = Complementary Supplement: TLS CORE + Isotonix Activated B-Complex

19. Scientific Support Alam MA, Uddin R, Subhan N, Rahman MM, Jain P, Reza HM. Beneficial role of bitter melon supplementation in obesity and related complications in metabolic syndrome. J Lipids 2015; 2015:496169. Anderson, R. Effects of chromium on body composition and weight loss. Nutrition Reviews. 56(9): 266-270, 1998. Anderson, R., et al. Chromium supplementation of human subjects: effects on glucose, insulin, and lipid variables. Metabolism. 32(9): 894-899, 1983. Bano F, Akthar N, Naz H. Effect of the aqueous extract of Momordica charantia on body weight in rats. J Basic Applied Sci 2011; 7(1):1-5. Bao B, Chen YG, Zhang L, Na Xu YL, Wang X, Liu J, Qu W. Momordica charantia (Bitter Melon) reduces obesity-associated macrophage and mast cell infiltration as well as inflammatory cytokine expression in adipose tissues. PLoS One 2013; 8(12):e84075. Barrett ML, Udani JK. A proprietary alpha-amylase inhibitor from white bean (Phaseolus vulgaris): a review of clinical studies on weight loss and glycemic control. Nutr J 2011; 10:24 Carai MA, Fantini N, Loi B, Colombo G, Riva A, Morazzoni P. Potential efficacy of preparations derived from Phaseolus vulgaris in the control of appetitie, energy intake, and carbohydrate metabolism. Diabetes Metab Syndr Obes 2009; 2:145-153 Carai MAM, Fantini N, Loi B, Colombo G, Gessa GL, Riva A, Bombardelli E, Morazzoni P. Multiple cycles of repeated treatments with a Phaseolus vulgaris dry extract reduce food intake and body weight in obese rats. British J Nutr 2011; 106:762-768. Cefalu, W. and Hu, F. Role of chromium in human health and in diabetes. Diabetes Care. 27: 2741- 2751, 2004. Celleno, L., et al. A dietary supplement containing standardized Phaseolus vulgaris extract influences body composition of overweight men and women. International Journal of Medical Sciences. 4(1):45-52, 2007. Chan LL, Chen Q, Go AG, Lam EK, Li ET. Reduced adiposity in bitter melon (Momordica charantia)-fed rats is associated with increased lipid oxidative enzyme activities and uncoupling protein expression. J Nutr 2005; 135(11):2517-23. Chen Q, Chan LL, Li ET. Bitter melon (Momordica charantia) reduces adiposity, lowers serum insulin and normalizes glucose tolerance in rats fed a high fat diet. J Nutr 2003; 133(4):1088-93.

20. Scientific Support Fox, G. and Sabovic, Z. Chromium picolinate supplementation for diabetes mellitus. The Journal of Family Practice. 46: 83-86, 1998. French, S. Effects of dietary fat and carbohydrate on appetite vary depending upon site and structure. British Journal of Nutrition. 93(Supplement 1): S23-S26, 2004. Grube B, Chong WF, Chong PW, Riede L. Weight reduction and maintenance with IQP-PV-101: a 12-week randomized controlled study with a 24-week open label period. Obesity 2014; 22:645-651. Huang HL, Hong YW, Wong YH, Chen YN, Chyuan JH, Huang CJ, Chao PM. Bitter melon (Momordica charantia L.) inhibits adipocyte hypertrophy and down regulates lipogenic gene expression in adipose tissue of diet-induced obese rats. Br J Nutr 2008; 99(2):230-9. Kaats, G., et al. A randomized, double-masked, placebo-controlled study of the effects of chromium picolinate supplementation on body composition: a replication and extension of a previous study. Current Therapeutic Research. 59(6): 379-387, 1998. Kuate, D., et al. The use of LeptiCore in reducing fat gain and managing weight loss in patients with metabolic syndrome. Lipids in Health and Disease. 9: 1-7, 2010. Lee, N. and Reasner, C. Beneficial effect of chromium supplementation on serum triglyceride levels in NIDDM. Diabetes Care. 17(12): 1449-1452, 1994. Martin, J., et al. Chromium picolinate supplementation attenuates body weight gain and increases insulin sensitivity in subjects with type 2 diabetes. Diabetes Care. 29(8): 1826-1832, 2006. Nerurkar PV, Johns LM, Buesa LM, Kipyakwai G, Volper E, Sato R, Shah P, Feher D, Williams PG, Nerurkar VR. Momordica charantia (bitter melon) attenuates high-fat diet-associated oxidative stress and neuroinflammation. J Neuroinflammation 2011; 8:64. Nerurkar PV, Lee YK, Nerurkar VR. Momordica charantia (bitter melon) inhibits primary human adipocyte differentiation by modulating adipogenic genes. BMC Complement Altern Med 2010; 10:34. Obiro, W., et al. The nutraceutical role of Phaseolus vulgaris alpha-amylase inhibitor. British Journal of Nutrition. 100: 1-12, 2008.

21. Scientific Support TLS ACTS Ingredients  Pittler, M. and Ernst, E. Dietary supplements for body-weight reduction: a systematic review. American Journal of Clinical Nutrition. 79(4): 529-536, 2004.  Preuss H. Bean amylase inhibitor and other carbohydrate absorption blockers: effects on diabesity and general health. Journal of the American College of Nutrition. 28(3):266-76, 2009.  Rabinovitz, H., et al. Effect of chromium supplementation on blood glucose and lipid levels in type 2 diabetes mellitus elderly patients. International Journal of Vitamin and Nutrition Research. 74(3):178-82, 2004.  Shih CC, Lin CH, Lin WL. Effects of Momordica charantia on insulin resistance and visceral obesity in mice on high-fat diet. Diabetes Res Clin Pract 2008; 81(2):134-43.  Spadafranca A, Rinelli S, Riva A, Morazzoni P, Magni P, Bertoli S, Battezzati A. Phaseolus vulgaris extract affects glycometabolic and appetite control in healthy human subjects. British J Nutr 2013; 109:1789-1795.  Sparti, A., et al. Effect of diets high or low in unavailable and slowly digestible carbohydrates on the pattern of 24-h substrate oxidation and feeling of hunger in humans. The American Journal of Clinical Nutrition. 73: 1462-1468, 2000.  TalYeh, G., et al. Systematic review of herbs and dietary supplements for glycemic control in diabetes. Diabetes Care. 26(4): 1277-1294, 2003.  Udani J., et al. Blocking carbohydrate absorption and weight loss: a clinical trial using Phase 2 brand proprietary fractionated white bean extract. Alternative Medicine Review 9(1):63-9, 2004.  Udani, J, Singh B. Blocking carbohydrate absorption and weight loss: a clinical trial using a proprietary fractionated white bean extract. Alternative Therapies in Health and Medicine. 13(4):32-7, 2007.  Zhu Z, Jiang W, Thompson HJ. Edible dry bean consumption (Phaseolus vulgaris L.) modulates cardiovascular risk factors and diet-induced obesity in rats and mice. British J Nutr 2012; 108:S66-S73.

22. TLS CORE Product Information Code: UK6462/ UK6462IBV Pricing: DC: £39.75 SR: £55.50 BV/IBV: 40 Use: Take 2 tablets twice daily 60 servings (30 days)

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