1. Professor Hyungil Jung
Microneedles:
Next Generation of Drug Delivery
JUVIC Biotech. Inc.
Yonsei University
(South Korea)
Shayan F. Lahiji
Professor Hyungil Jung

2. Routes of Administration
Oral Delivery
Inhalation
Injection
Implantation
Transdermal

3. Microneedle and insulin needle
A micro dimensioned needle
Insulin needle (33Guage)
Microneedle and insulin needle

4. Types of Microneedle

5. Dissolving Microneedle
Types of Microneedle
Solid Microneedle
Dissolving Microneedle
Hollow Microneedle
Coated Microneedle

6. Hollow Microneedle

7. Hollow Microneedle

8. Blood Extraction

9. Hollow Microneedle Drug Delivery
Hypodermic needle
Tower Microneedle

10. Sub retinal Drug Delivery

11. Dissolving Microneedle
A dissolving microneedle (DMN) is a micro-sized needle made of biodegradable polymer that encapsulates pharmaceuticals within a matrix and releases the drugs after skin insertion via dissolving of the polymeric compound.
Active compound absorbed skin tissue
Permeation
Dissolve
Dissolving microneedle: minimally invasive
Traditional needle: Pain!

12. Dissolving microneedle is a novel drug delivery tool.
Potential of Dissolving Microneedle
Dissolving microneedle is a novel drug delivery tool.
Chemical drug
Biomedicine
Cosmetics

13. Potential of Dissolving Microneedle
Since 1990s, various dissolving microneedle fabrication and delivery methods were developed. However, only few of traditional dissolving microneedles were commercialized and that was only in cosmetics
(not in biomedicine).

14. Dissolving Microneedle Patch
Belief in dissolving microneedle
Dissolving Microneedle Patch
Microneedle
Application
Active Compound
Delivery
SKIN

15. Key factors of dissolving microneedle
Hidden Truth of the dissolving microneedle
The essential of drug delivery is to deliver i) any drug, in ii) active form, with iii) require dose and iv) complete delivery.
Key factors of dissolving microneedle
Traditional process results limitations in;
① Solubility of drugs (lipophilic/hydrophilic)
② Activity of sensitive drugs (drug loss by forming polymer solution)
③ Amount of loaded drugs (drug/polymer ratio)
④ Viscosity of polymer solution (molecular weight, concentration)
⑤ Delivery efficacy into skin (application site and time limited)
Denatured drug
Active drug
Any Drug?
Drug activity?
Enough-dose?
Complete Delivery?

16. Polymer-drug solution
Traditional dissolving microneedle developing process
Drug
solution
Polymer solution
Shaping
technique
Patch system
Drug
Solvent
Drug
solution
Polymer-drug solution
Microneedle
fabrication
Patch application ① ② ③ ④
Micromolding
Drawing
DAB
본 슬라이드는 기존 생분해성 마이크로니들을 만드는 과정을 보여주는 것임.
각 단계에서 문제점이 발생한 다는 것을 보여 줄 것.
예를 들면
1 단계에서는 탑재할 수 있는 약물의 한계
이 슬라이드를 보여 준 후 각각의 문제점들에 대해 한페이지의 슬라이드 준비

17. Innovative polymer system Lipophilic Drug Loading
Any Drug?
Innovative polymer system
Lipophilic Drug Loading

18. Activity Improvement Drug activity? Enough-dose?
Insulin
x 300 !!
Direct & High dose powder loaded DMN
Highly concentrated powder loading
Maximizing the amount of drug loaded in DMN
 Ultra-high activity of bio-drug

19. Polymers used as backbone materials
CMC: Carboxymethylcellulose (sodium salt)
Cellulose derivatives with carboxymethyl groups (-CH2-COOH) bound to some of the hydroxyl groups of the glucopyranose monomers
Type
Low viscosity
Medium viscosity
High viscosity
Uses
Viscosity modifier
Thickener
Emulsion stabilizer
Detergent, Food additive, toothpaste, Pharmaceutical, Implantation
US-FDA approved for medical use

20. Polymers used as backbone materials
PVP: Polyvinylpyrrolidone
Water-soluble polymer made from the monomer N-vinylpyrrolidone
Type
2,500 to 2,500,000 dalton
Uses
Binder of pharmaceutical tablet
Stabilizer
Emulsifier
Membrane formation
Thickener
Disinfectant properties with iodine (povidone-iodine)
US-FDA approved for medical use

21. Polymers used as backbone materials
HA: Hyaluronic Acid (sodium salt)
Anionic, nonsulfated glycosaminoglycan
of connective, epithelial and neural tissue
Type
5,000 to 20,000,000 dalton
Uses
Wound repair (early inflammation promoter)
Skin structure (ECM: extra cellular matrix)
Treat osteoarthritis
US-FDA approved for medical use

22. Novel Fabrication Methods
Patented by
JuVic Biotech Co.
Activity?
Through C-Method we can fabricate Various forms of Dissolving Microneedles and ensure it maintains its activity.

23. Novel Fabrication Methods
Fastest available Fabrication Method
Within 5 minutes
Dose control
Temperature control

24. Novel Fabrication Methods

25. Novel Fabrication Methods
Droplet-born Air Blowing
Base preparation
Droplet dispensing
Droplet contact
Microneedle length control
Air blowing and separation

26. Novel Fabrication Methods

27. Dissolving microneedle delivery system
Limitation of incomplete patch administration
11.0 N
16.4 N
Complete Delivery?
Dissolving microneedle delivery system
Micro-lancer

28. Limitation of incomplete patch administration

29. Hair-less skin (Patch)
Limitation of incomplete patch administration
Hair-less skin (Patch)
Hairy skin (Patch)
Microlancer
Microlancer
Patch

30. Implantable micro-capsule Innovative polymer system (IPS)
JUVIC - Innovative technologies using microneedles
- Innovation Company for Microneedle
- Total solution using microneedle for transdermal delivery
Traditional
DMN patch
Precision
DMN patch
Micro-lancer
Shooter
Implantable micro-capsule
DMN on micro-pillar
Innovative polymer system (IPS)
Summary
Transdermal delivery of compounds by attaching adhesive patch with DMN array
Precision delivery of drugs by attaching adhesive patch with DMN array
Shooting DMNs into skin by using a convenient micro-lancer applicator
Implanting micro-capsule with DMN into skin to deliver powder drugs
Perfect penetration and delivery of DMNs fabricated on micro-pillars
Loading lipophilic drugs by using amphipathic polymer system
이 슬라이드에는 JUBIK에 대한 설명을 할 것.
포함 될 내용.
경피 전달을 위한 마이크로니들에 대한 토탈 솔루션(기술)을 가지고 있는 세계 유일의 회사
위 종합적인 그림을 이용.
기술의 combination에 따라 경피 전달의 모든 문제를 해결할 수 있음.
기존의 회사는 우리가 가지고 있는 기술 중 일부만 가지고 있음.
슬라이드 2~3장 정도로 회사가 가지고 있는 기술의 장점을 부각할 것.
Applications
Cosmetics
Cosmetics
Bio-pharmacy
Vaccines
Bio-pharmacy
Vaccines
Alopecia
Arthritis
Bio-pharmacy
Vaccines
Alopecia
Arthritis
Cosmetic filler
Bio-pharmacy
Alopecia
Arthritis
Lipophilic drugs
Alopecia
Arthritis
JUVIC Biotech. Inc.

31. JUVIC – Practical products
Cosmetics
Non-patch
anti-wrinkle
cosmetics
Whitening
cosmetics
Precision
DMN patch
Micro-lancer
Shooter
Precision
DMN patch
Innovative polymer system (IPS)
Retinyl retinoate
Vitamin C derivative
Alopecia
treatment
cosmetics
Long-lasting
cosmetic filler
Micro-lancer
Shooter
Implantable micro-capsule
Precision
DMN patch
DMN on
micro-pillar
High molecular weight HA
Corticosteroid
Biomedicine
High dose
powder drug delivery
Lipophilic
drug
delivery
Precision
DMN patch
Implantable micro-capsule
Precision
DMN patch
Innovative polymer system (IPS)

32. Photographs of subject wrinkles
JUVIC – Previous products
- Anti-wrinkle dissolving microneedle patch
Before application
After 12 weeks
RR-DMN
AA-DMN
Photographs of subject wrinkles
at 0 weeks and 12 weeks

33. JUVIC – Previous products

34. Professor Hyungil Jung Nano-biotechnology Lab members:
Acknowledgement
Professor Hyungil Jung
Nano-biotechnology Lab members:
Manita Dangol
Changyeol Lee
Sunguk Lee
Huisuk Yang
Suyong Kim
Mingyu Jang
Chisong Lee
Inyong Heo

35. Thank You! Shayan F. Lahiji Shayan@yonsei.ac.kr Professor Hyungil Jung