1. MICROSPHERES AS A NOVEL DRUG DELIVERY SYSTEM Omkar. T, Vikas College of Pharmacy, Vissannapet, Andhrapradesh For more presentations and information visit http://www.pharmaxchange.infohttp://www.pharmaxchange.info

2. Introduction Microspheres Synthetic polymers Non-bio degradable Polymethyl methacrylate, Acrolein, Epoxy polymers… Bio – degradable Lactides, Polyanhydrides, Polyalkyl cyno acrylates.. Natural polymers Proteins, Carbohydrates, Chemcally modified Carbohydrates….. For more presentations and information visit http://www.pharmaxchange.infohttp://www.pharmaxchange.info

3. Methods of Preparation Single emulsion techniqueSingle emulsion technique Double emulsion techniqueDouble emulsion technique Polymerization techniquePolymerization technique Spray drying techniqueSpray drying technique Solvent extractionSolvent extraction For more presentations and information visit http://www.pharmaxchange.infohttp://www.pharmaxchange.info

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5. Applications Synthetic polymers:- Parenteral preparations-- Poly alkyl cyanoacrylates Parenteral preparations-- Poly alkyl cyanoacrylates Narcotic antagonists, cancer drugs-- Poly lactic acidsustained release Narcotic antagonists, cancer drugs-- Poly lactic acidsustained release ocular delivery-- Poly anhydrate microspheres ocular delivery-- Poly anhydrate microspheres Natural polymers Albumin – Targeted drug delivery to Tumor cells. Albumin – Targeted drug delivery to Tumor cells. Gelatin microspheres – interferon, phagocytes. Gelatin microspheres – interferon, phagocytes. Starch – more -OH groups, so all drugs Starch – more -OH groups, so all drugs For more presentations and information visit http://www.pharmaxchange.infohttp://www.pharmaxchange.info

6. In vaccine therapy Monoclonal antibody therapy Chemo embolisation In radiology treatment for cancer In cosmetic technologies For more presentations and information visit http://www.pharmaxchange.infohttp://www.pharmaxchange.info

7. Future: Atrigel Drug Delivery System The Atrigel® drug delivery system consists of biodegradable polymers dissolved in biocompatible carriers. Pharmaceuticals may be blended into this liquid delivery system at the time of manufacturing or, depending upon the product, may be added later by the physician at the time of use. When the liquid product is injected into the subcutaneous space through a small gauge needle or placed into accessible tissue sites through a cannula, water in the tissue fluids causes the polymer to precipitate and trap the drug in a solid implant. The drug encapsulated within the implant is then released in a controlled manner as the polymer matrix biodegrades with time. For more presentations and information visit http://www.pharmaxchange.infohttp://www.pharmaxchange.info

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