1. Finola Delamere, Managing Editor at the editorial base of the Cochrane Skin Group www.skin.cochrane.org Centre of Evidence Based Dermatology (CEBD) Nottingham, UK 1

2. Cochrane & the Cochrane Skin Group 2

3. 3 Rationale for Cochrane  Collective ignorance about effects of healthcare  Overwhelming amount of clinical information  A systematic approach needed to organising and evaluating clinical trial data  The Cochrane systematic review

4. 4 What is Cochrane?  It is an international organisation of individuals who write & publish Cochrane systematic reviews  It prepares and maintains the Cochrane Library which is published online  It is the principle source of up-to-date high quality evidence on the effects of healthcare interventions

5. 5 International Cochrane Centres South African Australasian Chinese Brazilian Nordic German Italian Iberoamerican Dutch UK Canadian US South Asian French

6. 6 Cochrane - structure 52 Editorial Review Groups 10 Fields & networks The Consumer Network 14 International Centres 17 Methods Groups Steering Group & Central Editorial Unit Cochrane skin group editorial base & the French satellite

7. 7 Why ‘Cochrane’ ?  Archie Cochrane, a British epidemiologist, pointed out the deficiencies of current reviews of the medical literature in Cochrane AL (1972). 'Effectiveness and Efficiency: random reflections on health services'.  Iain Chalmers - an obstetrician. The first ‘Cochrane Centre’ opened in Oxford 1992.

8. 8 What makes a Cochrane review?  Structured process involving several steps  Well formulated question  Team effort  Comprehensive data search  Unbiased selection and abstraction process  Critical appraisal of data  Synthesis of data

9. 9 Stages of a Cochrane Review  Submit a title-the idea  Write the protocol-the plan  Write the review-the product

10. 10

11. Intervention reviews published 2015  Oral fumaric acid esters for psoriasis (#90)  Anti-TNF agents for paediatric psoriasis (#137)  House dust mite reduction and avoidance measures for treating eczema (#130)  Topical tacrolimus for atopic dermatitis (#69) 11

12.  Complementary therapies for acne vulgaris (#110)  Interventions for hirsutism (excluding laser and photoepilation therapy alone) (#142)  Topical antifungals seborrhoeic dermatitis (#120)  Topical antifungals for seborrhoeic dermatitis (#120)  Sentinel lymph node biopsy followed by lymph node dissection for localised primary cutaneous melanoma (#126)  Interventions for prevention of herpes simplex labialis (cold sores on the lips) (#92)  Interventions for hidradenitis suppurativa (#81) 12

13. Updated reviews   Interventions for vitiligo (#24)   Interventions for rosacea (#25)   Safety of topical corticosteroids in pregnancy (#119) 13

14. Protocols   Systemic pharmacological treatments for chronic plaque psoriasis (#156)   Interventions for guttate psoriasis (#02)   Antistreptococcal interventions for guttate and chronic plaque psoriasis (#16)   Interventions for chronic palmoplantar pustulosis (#06) 14

15.   Interventions for necrotizing soft tissue infections in adults (#158)   Indoor salt water baths followed by artificial ultraviolet B light for chronic plaque psoriasis (#117)   Effects of systemic immunosuppressive therapies for moderate-to-severe eczema in children and adults (#154)   Interventions for acne scars (#14)   Lifestyle changes for treating psoriasis (#161) 15

16. Diagnostic Test Accuracy reviews   Tests to assist in the diagnosis of cutaneous melanoma in adults: a generic protocol (#164)   Tests to assist in the diagnosis of keratinocyte skin cancers in adults: a generic protocol (#165) 16

17. Life after publication  Dissemination strategy –to each review team  Co-publications- in BJD; JAAD  Podcasts – the Oral evening primrose oil and borage oil for eczema was podcasted in 13 different languages!  Blogs – by  Blogs – by Knowledge Broker, Cochrane UK  CEBD sends out monthly evidence updates to derm community  Guidelines- mixed success 17

18. Skin Group reviews used in guidelines in UK, USA, Canada & by WHO  Interventions for bullous pemphigoid  Topical treatments for chronic plaque psoriasis  Interventions for alopecia areata  Topical antifungal treatments for tinea cruris and tinea corporis  Interventions to reduce Staphylococcus aureus in the management of atopic eczema  Surgical excision margins for primary cutaneous melanoma. 18