1. Permeability of Cell Membrane Advanced Biology

2. Transport Vocabulary Concentration gradient  Difference in the concentration of a substance throughout across a space (inside vs. outside of the cell) Equilibrium  Concentration of a substance is equal throughout a space

3. Cell Membrane Responsible for regulating what goes in and out of the cell  Can go through the phospholipids Small, uncharged molecules Oxygen, water, carbon dioxide Non-polar molecules diffuse much faster than polar molecules  Can go through membrane proteins Ions and large molecules Macromolecules-sugars, proteins, etc.

4. Types of Transport Passive transport  Molecules are able to pass through the phospholipids on their own or may need the assistance of a membrane protein  Doesn’t use chemical energy (ATP)  Goes with concentration gradient (high  low) Active transport  Molecules need assistance by using a membrane protein  Uses chemical energy (ATP)  Goes against concentration gradient (low  high)

5. Passive Transport Diffusion  Simplest form of passive transport  Movement of molecules continues until they reach equilibrium (distributed equally inside and outside the cell)  Only a few types of molecules will go across the cell membrane this way (oxygen into the bloodstream)  Temperature, pressure, electrical current, and molecule size can affect rate at which diffusion occurs

6. Passive Transport Osmosis  Diffusion of water molecules across a membrane  Osmotic pressure occurs when pressure develops in a system (cell) due to osmosis; necessary for osmosis to occur

7. Osmotic Solutions Isotonic  Concentration of water (solvent) and the solute are the same inside and outside the cell Hypotonic  Concentration of water is greater outside the cell than inside the cell (high solute inside, low outside)  Water moves inside causing cell to swell (lyse) Hypertonic  Concentration of water is greater inside the cell than outside the cell (low solute inside, high outside)  Water moves outside causing cell to shrink (plasmolysis)

8. Osmotic Solutions Plants need a hypotonic environment  Cell wall prevents cell from lysing  Creates turgor pressure (pressure of the cell’s contents against the cell wall due to osmosis, determined by how much water is in the central vacuole); provides additional support for cell

9. Passive Transport with Carrier Proteins Facilitated diffusion is a form of passive transport that uses carrier proteins to carry large or charged molecules across the cell membrane  Proteins are specific to what they transport  Proteins will change shape as they allow the molecule to pass

10. Facilitated Diffusion with Carrier Proteins

11. Passive Transport with Channel Proteins Channel proteins act as “pores” in the cell membrane which allow ions to pass through  Also specific as to what they allow through  Don’t change shape as the molecule passes through  Transport occurs at a much faster rate than with carrier proteins

12. Transport using Channel Proteins

13. Active Transport Uses membrane proteins (pumps) to move molecules across the cell membrane  Pumps are integral proteins  Most proteins will change shape as the molecule passes through  Some bind with only one type of molecule, others bind with two different types May move molecules in same direction May move molecules in opposite directions

14. Active Transport Sodium-potassium pump (nerve cells)  Pumps three sodium (Na + ) ions out and two potassium (K + ) ions in Usually more Na + ions outside the cell and more K + ions inside the cell Na + is toxic to the cell (drives osmosis) K + important for chemical reactions in cell Proton pumps  Move protons (hydrogen ions) out of the cell (typically across mitochondria during cellular respiration)

15. Active Transport Endocytosis  Cells take in larger substances by forming a vesicle around the substance Pinocytosis: intake of smaller substances and fluids Phagocytosis: intake of large molecules and entire cells (bacteria)  White blood cells use endocytosis to get rid of foreign molecules (bacteria, viruses, etc.)

16. Endocytosis

17. Active Transport Exocytosis  Vesicles fuse with cell membrane to release substances outside the cell  Electrical impulses are converted into chemical messages and then are “exported” out of your cell through this process

18. Exocytosis

19. Active Transport Receptor proteins  Bind to specific signal molecules which enables cell to respond Usually allows for another molecule to pass through the channel protein  Causes receptor protein to change shape to allow molecule to enter/exit cell  Causes an intermediate protein to activate which activate an enzyme which forms a second messenger

20. Receptor Proteins

21. Learning Targets I can name the two types of movement through the cell membrane. I can explain differences between active and passive transport. I can describe examples of active and passive transport.