1. DISORDERS OF THE RESPIRATORY SYSTEM

2. Effects of Smoking Known to cause:  Cancer  COPD  Asthma

3. Effects of Smoking 3 Problematic Substances:  Nicotine – addictive, stimulates reward pathway in the brain  Carbon Monoxide – hemoglobin has a greater tendency to bind to carbon monoxide than oxygen (200 times stronger bond)  Tar – accumulates in the alveoli = prevents gas exchange

6. Asthma A chronic respiratory dieses characterized by inflammation and swelling of the bronchi and bronchioles that obstructs airflow

7. Asthma Inflammation is a protective reaction designed to eliminate some foreign substances or infection Swelling – more blood to the area Production of mucus Muscles around the bronchi and bronchioles contract  ALL this = reduced air flow

8. Although the causes of asthma are not known, the condition is often associated with allergies. An allergic reaction initiates the swelling of the tissues and the tissues which line the walls of the bronchioles swell. Also, an allergic reaction causes spasms of the muscles lining the bronchiole walls. Asthma

9. Medication for Asthma Open up or dilate the bronchi and bronchioles to allow greater airflow Puffers: Corticosteroids suppress the multiple inflammatory genes that are activated

10. Chronic Obstructive Pulmonary Disease (COPD) ~90% of COPD caused by smoking a chronic, progressive disease that involves both: 1. Obstructive Bronchitis  inflammation and mucus (similar to asthma) 2. Emphysema  Causes permanent damage to the alveoli, they loose elasticity and shape = decrease surface area for gas exchange

11. NO CURE – Damage to alveoli is permanent

12. Bronchitis Bacterial or viral infections as well as reactions to environmental chemicals can cause a variety of ailments characterized by a narrowing of air passages. It is characterized by an inflammation of the mucous lining of the bronchial tubes. The excess production of mucus leads to inflammation and tissue swelling, a narrowing of the air passages, and decreased air movement through the bronchi.

13. The condition becomes more serious in the bronchioles which are not supported by rings of cartilage that help keep them open. Two conditions, bronchial asthma and emphysema, are associated with inflammation of the bronchioles. In both conditions, greater effort is required to exhale than to inhale. This occurs because lower pressure is produced in the lungs and bronchioles during inspiration. Bronchitis

14. During expiration, increased pressure in the chest cavity compresses the lungs and the bronchioles, decreasing the diameter of the bronchioles and increasing resistance to airflow. The imbalance between the amount of air entering the lungs and the amount of air leaving the lungs must be met by increasing the exertion of expiration Bronchitis

15. Emphysema Emphysema is associated with long-term bronchitis. It involves an increased resistance to airflow through the bronchioles. Although air flows into the alveoli fairly easily, the decreased diameter of the bronchioles creates resistance to the movement of air out of the lungs. Air pressure builds up in the lungs (emphysema means “over inflated”). Unable to support the building pressure, the thin walls of the alveoli stretch and eventually rupture.

16. The fact that there are fewer alveoli means there is less surface area for gas exchange which leads to decreased oxygen levels. In the body’s attempt to maintain homeostasis, the breathing rate increases and exhalation becomes more laboured. The circulatory system adjusts by increasing the heart rate. Emphysema

17. Another problem is that adjoining pulmonary capillaries and alveoli are both destroyed. Although blood clotting prevents any major internal hemorrhaging, the tissue of the lungs is replaced by scar tissue, the lungs are less able to expand, and therefore they hold less air. Inhaled steroids. Corticosteroid drugs inhaled as aerosol sprays may relieve symptoms of emphysema associated with asthma and bronchitis. Although inhaled steroids have fewer side effects than oral steroids do, prolonged use can weaken your bones and increase your risk of high blood pressure, cataracts and diabetes. Protein therapy Antibiotics Transplant Emphysema

18. Treatment Bronchiodilators: These drugs can help relieve coughing, shortness of breath and trouble breathing by opening constricted airways, but they're not as effective in treating emphysema as they are in treating asthma. Emphysema

19. Lung Cancer More Canadian men and women die from lung cancer than from any other form of cancer. There is uncontrolled growth of cells and the solid mass of cancer cells in the lungs greatly decreases the surface area for diffusion. Tumours may actually block bronchioles, reducing airflow to the lungs and potentially causing the lungs to collapse.

21. Treatment Surgery Radiation therapy Chemotherapy Prevention: no smoking, avoid second-hand smoke, avoid carcinogens

22. Cystic Fibrosis Normally, mucus is watery. It keeps the linings of certain organs moist and prevents them from drying out or getting infected. But in CF, an abnormal gene causes mucus to become thick and sticky. The mucus builds up in your lungs and blocks the airways. This makes it easy for bacteria to grow and leads to repeated serious lung infections. Over time, these infections can cause serious damage to your lungs.

23. Causes of CF Mutation on Chromosome 7, deletion of 3 amino acids Causes abnormal membrane protein to develop which does not allow the passage of chloride ions across the membrane

24. Treatment Patient specific depending on age and severity of disorder percussion and postural drainage, to help loosen the mucus to unclog the lungs pancreatic enzymes, taken with all meals, to aid digestion nutritional supplements and vitamins to promote good nutritional status inhalation of aerosol medications, to alleviate congestion and prevent and treat lung infection exercise