Table 1. Clinical characteristics of subjects Mean ± s.d. n1363 Age (years)55.6 ± 14.1 Genders, % Males49.1 Females50.9 Diabetes, %44.9 Hypertension, %14.0.

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Table 1. Clinical characteristics of subjects Mean ± s.d. n1363 Age (years)55.6 ± 14.1 Genders, % Males49.1 Females50.9 Diabetes, %44.9 Hypertension, %14.0 Measurements Urine protein, mg/day806 ± 2150 WBC, mm ± 3083 Hb, g/dL12.2 ± 1.9 Platelet, mm ± Protein, g/dL6.7 ± 2.7 Albumin, g/dL3.8 ± 0.6 Total cholesterol, mg/dL204 ± 77 LDL Cholesterol, mg/dL115 ± 43 HDL cholesterol, mg/dL44 ± 15 Triglycerides, mg/dL158 ± 209 AST, IU/L28 ± 22 ALT, IU/L27 ± 24 Fasting blood glucose, mg/dL144 ± 73 BUN, IU/L18.6 ± 10.4 Creatinine, IU/L1.16 ± 0.64 eGFR, mL/min/1.73m 2 75 ± 31 Uric acid, IU/L5.4 ± 2.0 Sodium, mEq/L140.6 ± 4.8 Potassium, mEq/L4.2 ± 0.6 Calcium, mg/dL9.1 ± 0.7 Phosphorus, mg/dL4.0 ± 3.1 Chloride, mEq/L102 ± 11 total CO 2, mEq/L26.4 ± 4.9 Total Bilirubin, mg/dL0.75 ± 0.21 Direct Bilirubin, mg/dL0.30 ± 0.09

eGFR ≥ 90 mL/min/1.73 m 2, n = mL/min/1.73 m 2, n = mL/min/1.73 m 2, n = mL/min/1.73 m 2, n = 91 p-value Characteristics Age, years50.1 ± ± ± ± T 1) ab, ccc Genders, % Males Females Diabetes, % Hypertension, % Measurements Urine protein, mg/day572 ± ± ± ± T 1) aa, bbc WBC, mm ± ± ± ± Hb, g/dL12.5 ± ± ± T 1) aa bc Platelet, mm ± ± ± ± T 1) aa, b b Protein, g/dL6.7 ± ± ± ± Albumin, g/dL3.8 ± ± ± ± T 1) aaa, bb Total cholesterol, mg/dL204 ± ± ± ± LDL Cholesterol, mg/dL126 ± ± ± ± HDL cholesterol, mg/dL46 ± 1645 ± 1642 ± 1440 ± T 1) aa, bb, cc Triglycerides, mg/dL170 ± ± ± ± AST, IU/L29 ± 2729 ± 2027 ± 1629 ± ALT, IU/L28 ± 2528 ± 2324 ± 2026 ± Fasting blood glucose, mg/dL153 ± ± ± ± T 1) aa, bbb BUN, IU/L12.5 ± ± ± ± T 1) aabc Creatinine, IU/L0.71 ± ± ± ± T 1) abcd Total Bilirubin, mg/dL0.77 ± ± ± ± T 1) a, b b, cc Direct Bilirubin, mg/dL0.31 ± ± ± ± ) The same letters indicate non-significant difference between groups based on Turey's multiple comparison test Table 2. Age-gender standardized baseline demographics and laboratory results accordings to eGFR in the entire cohort (n= 1363)

24 hour urine protein (mg/day)< 150≥ 150P value Characteristicsn = 810n = 553 Age, years55.9 ± ± Genders, % Males Females Diabetes, % Hypertension, % eGFR, %, mL/min/1.73m ≥ Measurements WBC, mm ± ± Hb, g/dL12.5 ± ± Platelet, mm ± ± Protein, g/dL6.8 ± ± Albumin, g/dL4.0 ± ± Total cholesterol, mg/dL194 ± ± LDL Cholesterol, mg/dL115 ± ± HDL cholesterol, mg/dL45 ± 1543 ± Triglycerides, mg/dL148 ± ± AST, IU/L27 ± 2029 ± ALT, IU/L27 ± 2127 ± BUN, IU/L16.3 ± ± Creatinine, IU/L0.99 ± ± Total Bilirubin, mg/dL0.78 ± ± Direct Bilirubin, mg/dL0.30 ± ± Table 3. Age-gender standardized baseline demographics and laboratory results accordings to 24 urine protein excretion in the entire cohort (n= 1363)

Fasting blood glucose, mg/dL< 126≥ 126P value Characteristics Age, years53.9 ± ± Genders, %0.414 Males Females eGFR, %, mL/min/1.73m ≥ Measurements 24 hour urine protein, mg/day913 ± ± WBC, mm ± ± Hb, g/dL12.0 ± ± Platelet, mm ± ± Protein, g/dL6.7 ± ± Albumin, g/dL3.7 ± ± Total cholesterol, mg/dL207 ± ± LDL Cholesterol, mg/dL114 ± ± HDL cholesterol, mg/dL46 ± 1642 ± Triglycerides, mg/dL140 ± ± AST, IU/L28 ± 2028 ± ALT, IU/L24 ± 1930 ± BUN, IU/L19.0 ± ± Creatinine, IU/L1.24 ± ± Total Bilirubin, mg/dL0.75 ± ± Direct Bilirubin, mg/dL0.30 ± ± eGFR, mL/min/1.73m 2 71 ± 3180 ± Table 4. Age-gender standardized baseline demographics and laboratory results accordings to fasting blood glucose (n= 1363)