Inserm U1216 Research Center – Université Grenoble Alpes Director: Frédéric Saudou email: frederic.saudou@inserm.fr

Our scientific goals To understand the brain To develop innovative therapies for brain diseases (Alzheimer, Parkinson, Huntington, Epilepsy, Cancer, Schizophrenia, Stroke…) GIN

The GIN A Center Dedicated to Fundamental and Clinical Research in Neuroscience “Edmond J. Safra” built in 2007 6000 m2 dedicated to research Located on Grenoble Medical campus Close location to the neurology, psychiatry and neuroscurgery departments and the MRI medical facilities GIN

Our institutional partners Funding and administrative agencies Université Joseph Fourier => Université Grenoble Alpes Institut National pour la Santé et la Recherche Médicale (Inserm) Partners Centre Hospitalier Universitaire (CHU) - Grenoble Commissariat à l’Energie Atomique et aux Energies Alternatives (CEA) European Synchrotron Radiation Facilities (ESFR) Centre National de Recherche Scientifique (CNRS) GIN

Our aspirations The GIN as a cutting-edge center for neuroscience with multidisciplinary approaches From molecules to brain signals to decipher brain functions and develop novel therapies

Our strategy Our strengths A continuum from molecules, cells, small animals to human for the study of neurological, neuromuscular and psychiatric disorders Our strengths Cellular and molecular biology of the neuronal cytoskeleton Predictive animal models of brain pathologies Human genetics Functional neurosurgery and deep brain stimulation Functional MRI coupled to electrophysiology Mapping of neuronal networks Cognition and behavior

Our opportunities Our strategy A continuum from molecules, cells, small animals to human for the study of neurological, neuromuscular and psychiatric disorders Our opportunities Grenoble University Hospital Large instruments such as synchrotron Health Engineering (Clinatec, TIMC) Multidisciplinarity with mathematics, physic, imaging centers Neurosciences in Grenoble University Hospital Federation (FHU) Neuropsynov

Up to 200 neuroscientists 23 nationalities since 2009 GIN As of January 2015 23 nationalities since 2009 GIN

Research teams GIN 2016-2020 9 research teams Isabelle Arnal Cytoskeleton Dynamics and Structure Annie Andrieux Physiopathology of Cytoskeleton Alain Buisson Neuropathology and Synaptic Dysfunction Isabelle Marty Muscle and Pathologies Antoine Depaulis Synchronization and Modulation of Neuronal Network in Epilepsy Olivier David Brain function and neuromodulation Emmanuel Barbier Functional NeuroImaging and Brain Perfusion Frédéric Saudou Intracellular dynamics and neurodegeneration Sandrine Humbert Neuronal progenitors and brain pathologies http://neurosciences.ujf-grenoble.fr (applications for young team leaders are welcome) Mettre les données telle que dans la fiche résumé Unité

Evolution of teams GIN 2009-2014 GIN 2016-2020 13 research teams Isabelle Arnal (AVENIR) Cytoskeleton Dynamics and Structure Annie Andrieux Physiopathology of Cytoskeleton Alain Buisson Neuropathology and Synaptic Dysfunction Rémy Sadoul Neurodegeneration and Plasticity Isabelle Marty Muscle and Pathologies Michel De Waard Calcium Channels, Functions and Pathologies Marc Savasta Dynamic and Pathophysiology of Basal Ganglia Antoine Depaulis Dynamics of synchronous epileptic networks Bruno Bonaz Stress and Neurodigestive Interactions Olivier David Brain function and neuromodulation François Berger Nanotechnology and Brain Emmanuel Barbier Functional NeuroImaging and Brain Perfusion François Estève Synchrotron Radiation and Medical Research GIN 2016-2020 9 research teams Isabelle Arnal (AVENIR) Cytoskeleton Dynamics and Structure Annie Andrieux Physiopathology of Cytoskeleton Alain Buisson Neuropathology and Synaptic Dysfunction Isabelle Marty Muscle and Pathologies Antoine Depaulis Synchronization and Modulation of Neuronal Network in Epilepsy Olivier David Brain function and neuromodulation Emmanuel Barbier Functional NeuroImaging and Brain Perfusion Frédéric Saudou Intracellular dynamics and neurodegeneration Sandrine Humbert Neuronal progenitors and brain pathologies Mettre les données telle que dans la fiche résumé Unité

Facilities Jan 2015 Transcriptomic Electronic Microscopy IBiSa Animal housing (Rodent/Primate) Imaging IBiSa – IsdV -> Guarantying the competitiveness of the facilities -> Investing in new technologies

Investing in new technologies Imaging facility Spinning Confocal microscopy/TIRF (large field, 380 k€) Support from Inserm (arrival of Saudou & Humbert teams) Super-resolution microscopy Bettencourt-Schueller prize to Saudou, 250 k€ Engineer position requested 2-Photon technology IBiSa support for new laser & set-up Light-sheet microscopy CUBIC, 3DISCO... prioritization for grants applications Renovation of lab space for an optimized facility (“PIC-GIN”) SAFRA donation to the GIN Biphoton Zeiss 7MP + … Light sheet micro Airy Scan Frigo 80 60 8,3 m2 5,4 m2 13,8 m2 O2 Air 2,86 m 9,86 m2 2,9 m 1 2 3 4 6 5

Translational and clinical research Brain samples from epileptic patients Sophie Hamelin, MD-PhD, Neurologist Pre-operative investigations at Grenoble University Hospital Resective surgery History Clinical Video-EEG Stereo-EEG MRI PET MEG Frozen samples for : Transcriptomic Immunolabeling Cell culture

Translational and clinical research Huntington’s disease working team A care circuit for Huntington’s disease patients Coordination: Elena MORO Multidisciplinary approach for patients care Neurologists Psychiatrists Geneticists Psychologists Insertion into NeuroPsynov FHU Interaction with basic, preclinical and clinical research groups Cell and molecular mechanisms Mouse models Experimental medicine & clinical testings

Neurostimulation and innovations in refractory neuro-psychiatric diseases NEUROPSYNOV Director : Philippe Kahane Deputy directors: Thierry Bougerol, Stéphan Chabardès RNPD can be studied together Shared: Symptoms and comorbidities Dysfunctions Neural networks Multidisciplinary expertise Common diagnostic tools Translational research

NEUROPSYNOV consortium GIN INSERM-U836 UJF Neuroimaging Neurobiology Animal models 18 research teams GIPSA-Lab CNRS-UMR5216 INPG-UJF-Stendhal Signal processing LPNC CNRS-UMR5105 UPMF Cognitive sciences NEUROPSYNOV consortium Hospital Psychiatry Neurology (Epi) Neurology (MD) Neurosurgery Neuropsychology Neurophysiology Neuroradiology 7 clinical teams CIC Addictology Physical Med. Nuclear Med. Genetics 10 core facilities CLINATEC Experimental neurosurgery Synchrotron ESRF LIPhy CNRS Morpheo INRIA Néel Institute 3 research federations SFR RMN UMS IRMaGe SFR PGC SFR HS University campus CHUG Interface physique-santé Background Objectives Partners Structuration Management Achievements Added value

Education in Neuroscience International Research Master 2 in Neuroscience 3 PhD programs : Life Sciences (Neuroscience) Physics Health Engineering, Cognition PhD students committee : “Neurodocs” Students seminars, workshops, trainings Public information (e.g.: the brain’s week) GIN

Communication Interface between science & society Internal communication: Newsletter for the GIN Internal booklet of ressources and competences External communication New Website Communication manager Targeting general public and medias