Unit 1- Microbiology A. Timeline 1. Look for important occurrences a. plagues b. advent of the microscope c. Pasteurella pestis- Bubonic plague d. Vaccinations- Jenner & Smallpox
d. Remember Redi and his maggots? 2. Biogenesis vs. Abiogenesis a. Living things can come from nonliving things b. Aristotle (600 BC) & van Helmont (1600’s) c. NO ONE discounted Aristotle! d. Remember Redi and his maggots? e. Needham- response to Redi using the microscope f. Spallanzanni- fixed Needham’s mistake =BUT, eliminated “living factor” g. Who solved the problem? -Louis Pasteur!
5. Pasteur studies fermentation: C6H12O6=>C2H5OH + CO2 3. Bacteria are shown to move through the air 4. Principles applied to health and infections a. Surgery & childbirth b. Concept of sterilization- heat @ 165 F. for 15 min. 5. Pasteur studies fermentation: C6H12O6=>C2H5OH + CO2 (ethyl alcohol) 6. Microbes get classified: -Bacillus (rod) -Coccus (round) -Spirillum (spiral)
Bacterial examples: E. coli
7. New discoveries become smaller and chemically specific 8 7. New discoveries become smaller and chemically specific 8. Bacteria were found to be giving off toxins a. poison b. followed by antitoxins in 1840 9. Chemical means of “coloring bacteria- a. Gram stain b. We’ll do this! 10. Discovery of VIRUSES at the turn of the century -(even though we could not see them)
11. Discovery of the body’s immune system a. antibodies b 11. Discovery of the body’s immune system a. antibodies b. histamines- led to the discovery of….? 12. Discovery of antibiotics a. By….? b. method of discovery- 13. Viruses finally seen in the 1940s after the discovery of the_________________. Bacteriophage