Lisa Grohskopf, MD, MPH U.S. Influenza Surveillance 2011-2012 Season National Center for Immunization & Respiratory Diseases Influenza Division U.S. Food.

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Presentation transcript:

Lisa Grohskopf, MD, MPH U.S. Influenza Surveillance Season National Center for Immunization & Respiratory Diseases Influenza Division U.S. Food and Drug Administration Vaccine and Related Biologic Products Advisory Committee Meeting February 28, 2012

Source: FluView, CDC

Characteristics of Recent Influenza Viruses Tested at CDC Of 397 U.S. viruses antigenically characterized at CDC since October 1, 2011:  58 (15%) Influenza A (H1N1)  56 (97%) A/California/7/2009-like  291 (73%) Influenza A (H3N2)  277 (95%) A/Perth/16/2009-like  48 (12%) Influenza B  22 (46%) Victoria lineage; 198 (99%) B/Brisbane/60/2008-like  26 (54%) Yamagata lineage Few B viruses available for testing in US Worldwide most similar to the vaccine strain Source: FluView, CDC

Percentage of Visits for Influenza-like Illness (ILI) Reported by the U.S. Outpatient Influenza-like Illness Surveillance Network (ILINet), Weekly National Summary, September 28, 2008 – February 18, 2012 Source: FluView, CDC

Number of Deaths Reported = Number of Deaths Reported = 282 Deaths Reported Current WeekDeaths Reported Previous Week Number of Deaths Reported = 122 Number of Influenza-Associated Pediatric Deaths by Week of Death: season to present Number of Deaths Reported = 3 Source: FluView, CDC

Human Infections with Swine Influenza A Viruses, United States 35 human cases of swine influenza A virus infection identified from Dec 2005 – Nov 2011 Previously ~ 1 case every 1-2 years Better diagnostics at SHDs Greater awareness All triple reassortant swine-origin viruses 13 H1N1, 20 H3N2, and 2 H1N2 infections

Reports of Swine-Origin Influenza A(H3N2)v, 2011 Occurred between 7/ / states (ME, IA, IN, WV, PA) Swine origin H3N2 with matrix (M) gene from A(H1N1)pdm 2009 Median age 3 years (range 11 months - 58 years) Mild to moderate influenza-like illness Estimated incubation period 2-4 days (range 1-7 days) Exposures: –4 with direct exposure to pigs –2 with indirect exposure –6 with potential human-to-human transmission Hemagglutinin genes related to H3N2 viruses circulated in 1990s –Adults and older children may have limited immunity Current seasonal vaccine not anticipated to provide significant protection (N=12)

For more information please contact Centers for Disease Control and Prevention 1600 Clifton Road NE, Atlanta, GA Telephone, CDC-INFO ( )/TTY: Web: Thank You! Acknowledgements: National Center for Immunization & Respiratory Diseases Influenza Division Lyn Finelli Lynnette Brammer Lenee Blanton Krista Kniss Amber Bishop Desiree Mustaquim Rosaline Dhara Michael Courter Scott Epperson Patrick Glew