FMRI and MR Spectroscopy. BOLD BOLD=Blood Oxygenation Level Dependant contrast Neurons at work use oxygen (carried by hemoglobin) 1-5 s. delay, peaks.

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Presentation transcript:

fMRI and MR Spectroscopy

BOLD BOLD=Blood Oxygenation Level Dependant contrast Neurons at work use oxygen (carried by hemoglobin) 1-5 s. delay, peaks at 4-5 s. T2 or T2* contrast 2-4 mm spatial resolution 1-4 s. temporal resolution

fMRI exam High resolution image of brain taken Series of scans over time –Lower resolution –T2 or T2* weighted Subject performs task, rests, performs task, rest, etc. Task can be visual, auditory, sensory, cognitive… Statistical analysis performed

Activated Regions

3D Reconstruction

Stroop Test opEffects.htmlhttp:// opEffects.html osure/strooptest.htmlhttp:// osure/strooptest.html Results: es/hb_study_03.htmhttp://spnl.stanford.edu/healthy_brain/studi es/hb_study_03.htm

Other Cognitive tests ash1.htmlhttp:// ash1.html Face recognition results ublications/MarottaGenoveseBehrmann pdfhttp:// ublications/MarottaGenoveseBehrmann pdf

MRS Image 1H NOT in water –Large voxel Molecules have distinct RFs –‘chemical shift’ = distance from RF of water Supress water signal to ‘see’ other signals

Chemical Shift Area under peak gives concentration

Cases