Anatomy and Physiology, Sixth Edition Rod R. Seeley Idaho State University Trent D. Stephens Idaho State University Philip Tate Phoenix College Chapter 7 Lecture Outline* *See PowerPoint Image Slides for all figures and tables pre-inserted into PowerPoint without notes. Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.

Chapter Plan The Muscular System Study Guide Projects Lab: Research: Diseases of the Muscular System One section a day – Due Fridays Location of Superficial Muscles (Group QUIZ) Lab: Quick Recall (GROUP QUIZ) Muscle Fatigue Lab Mastery Learning Activity (INDIVIDUAL QUIZ) Chicken Wing Dissection Final Learning Challenges (GROUP QUIZ) The Muscle System Tour Muscular System Lab (part 2 & 3 only) Quizzes/Exams Case Studies Quizlet Parts of a Muscle Quiz The Tired Swimmer Chapter Test Media: Video of runner/sprinter

Key Vocabulary

Muscular System: Histology and Physiology Chapter 7 Muscular System: Histology and Physiology

Muscular System Functions Body movement Maintenance of posture Respiration Production of body heat Communication Constriction of organs and vessels Heart beat

Properties of Muscle Contractility Excitability Extensibility Ability of a muscle to shorten with force Excitability Capacity of muscle to respond to a stimulus Extensibility Muscle can be stretched to its normal resting length and beyond to a limited degree Elasticity Ability of muscle to recoil to original resting length after stretched

Muscle Tissue Types Skeletal Smooth Cardiac Attached to bones Nuclei multiple and peripherally located Striated, Voluntary and involuntary (reflexes) Smooth Walls of hollow organs, blood vessels, eye, glands, skin Single nucleus centrally located Not striated, involuntary, gap junctions in visceral smooth Cardiac Heart Striations, involuntary, intercalated disks

Connective Tissue, Nerve, Blood Vessels Endomysium Perimysium Epimysium or Fascia Nerve and blood vessels Abundant

Checking in… Put the following in order from greatest to least Endomysium Perimysium Epimysium What do each of these connective tissue surround?

Parts of a Muscle

Quick Recap Put these muscle parts in order from largest to smallest Myofibril Skeletal muscle Muscle fiber Muscle fasciculi Myofilament (actin or myosin) On which of these muscle parts would you find: Sarcolemma? Sarcomere? Capillary and nuclei? Mitochondria?

Structure of Actin and Myosin

Components of Sarcomeres

Sliding Filament Model (p.163) Actin myofilaments sliding over myosin to shorten sarcomeres Actin and myosin do not change length Shortening sarcomeres responsible for skeletal muscle contraction During relaxation, sarcomeres lengthen

Sarcomere Shortening

Physiology of Skeletal Muscle Nervous system Controls muscle contractions through action potentials Resting membrane potentials Membrane voltage difference across membranes (polarized) Inside cell more negative and more K+ Outside cell more positive and more Na+ Must exist for action potential to occur

Ion Channels Types Ligand-gated Voltage-gated Example: neurotransmitters Voltage-gated Open and close in response to small voltage changes across plasma membrane

Action Potentials Phases All-or-none principle Propagate Frequency Depolarization Inside plasma membrane becomes less negative Repolarization Return of resting membrane potential All-or-none principle Like camera flash system Propagate Spread from one location to another Frequency Number of action potential produced per unit of time

Gated Ion Channels and the Action Potential

Action Potential Propagation

Neuromuscular Junction Synapse or NMJ Presynaptic terminal Synaptic cleft Postsynaptic membrane or motor end-plate Synaptic vesicles Acetylcholine: Neurotransmitter Acetylcholinesterase: A degrading enzyme in synaptic cleft

Function of Neuromuscular Junction

Excitation-Contraction Coupling Muscle fiber Mechanism where an action potential causes muscle fiber contraction Involves Sarcolemma Transverse or T tubules Terminal cisternae Sarcoplasmic reticulum Releases Ca2+ Troponin Ca binds to this

Action Potentials and Muscle Contraction

In pictures describe each of the following steps

Cross-Bridge Movement In words, describe each of the following steps

Checking in… Rigor mortis (stiffness + death) is a condition in which the muscles of a deceased person remains rigid. Explain why this might happen using what you learned about cross- bridges and muscle contraction. Answer: A new ATP must bind to mysoin before the cross- bridge can be released. When ATP is not available after a person dies, the cross-bridges that have formed are not released, causing the muscle to become rigid

Predict… Predict the consequences of having the following conditions develop in a muscle in response to a stimulus: Inadequate ATP is present in the muscle fiber before a stimulus is applied Adequate ATP is present within the muscle fiber, but action potentials occur at a frequency so great that calcium ions are not transported back into the sarcoplasmic reticulum between individual action potentials Answer: Energy from ATP is stored on the myosin heads. W/O ATP, no cross-bridges are formed, no muscle contraction Ca2+ is needed to bind to troponin molecules which exposes myosin attachment sites for cross-bridges to form. No Ca2+, no muscle contraction

More to check in… Why does a person’s body temperature increase after exercise? Why does a person shiver?

Muscle Twitch Muscle contraction in response to a stimulus that causes action potential in one or more muscle fibers Phases Lag or latent Contraction Relaxation

Stimulus Strength and Muscle Contraction All-or-none law for muscle fibers Contraction of equal force in response to each action potential Sub-threshold stimulus Threshold stimulus Stronger than threshold Motor units Single motor neuron and all muscle fibers innervated Graded for whole muscles Strength of contractions range from weak to strong depending on stimulus strength

Multiple Motor Unit Summation A whole muscle contracts with a small or large force depending on number of motor units stimulated to contract

Multiple-Wave Summation As frequency of action potentials increase, frequency of contraction increases Incomplete tetanus Muscle fibers partially relax between contraction Complete tetanus No relaxation between contractions Multiple-wave summation Muscle tension increases as contraction frequencies increase

Types of Muscle Contractions Isometric: No change in length but tension increases Postural muscles of body Isotonic: Change in length but tension constant Concentric: Overcomes opposing resistance and muscle shortens Eccentric: Tension maintained but muscle lengthens Muscle tone: Constant tension by muscles for long periods of time Keeps back & legs straight, head held upright, abdomen from bulging

Muscle Length and Tension

Fatigue Decreased capacity to work and reduced efficiency of performance Types Psychological Depends on emotional state of individual Muscular Results from ATP depletion Synaptic Occurs in NMJ due to lack of acetylcholine

Energy Sources ATP provides immediate energy for muscle contractions from 3 sources Creatine phosphate During resting conditions stores energy to synthesize ATP Anaerobic respiration Occurs in absence of oxygen and results in breakdown of glucose to yield ATP and lactic acid Aerobic respiration Requires oxygen and breaks down glucose to produce ATP, carbon dioxide and water More efficient than anaerobic Where does anaerobic respiration occur in the cell? Aerobic?

Checking in… Scenario: After a 10-mile run with a sprint at the end, a runner continues to breathe heavily for a time. Indicate the type of metabolism that is producing energy during the run, during the sprint, and after the run Answer: During the run, aerobic respiration is used to break down glucose to produce ATP, CO2 and H2O. During the sprint, anaerobic respiration is used to yield small amounts of ATP and lactic acid After the run, respiration rate and volume remain elevated to pay back the O2 debt. This is needed to convert lactic acid to glucose, replenish ATP and creatine phosphate in muscle fibers and replenish O2 in the lungs, blood, and muscles

Slow and Fast Fibers Slow-twitch or high-oxidative Contract more slowly, smaller in diameter, better blood supply, more mitochondria, more fatigue-resistant than fast-twitch Fast-twitch or low-oxidative Respond rapidly to nervous stimulation, contain myosin to break down ATP more rapidly, less blood supply, fewer and smaller mitochondria than slow-twitch Distribution of fast-twitch and slow twitch Most muscles have both but varies for each muscle Effects of exercise Hypertrophies: Increases in muscle size Atrophies: Decreases in muscle size

Checking in… When eating turkey, which do you prefer white or dark meat? Why is there such a difference? Answer: White meat (especially in chicken breast) is composed of mostly fast twitch muscle fibers – good for contracting rapidly for short periods of time and fatigues quickly Dark meat (especially in the chicken legs or duck’s breast) is composed myoglobin, richer blood supply and stores oxygen

Smooth Muscle Characteristics Types Not striated Dense bodies instead of Z disks as in skeletal muscle Have noncontractile intermediate filaments Ca2+ required to initiate contractions Types Visceral or unitary Function as a unit Multiunit Cells or groups of cells act as independent units

Smooth Muscle Contraction

Electrical Properties of Smooth Muscle

Functional Properties of Smooth Muscle Some visceral muscle exhibits autorhythmic contractions Tends to contract in response to sudden stretch but no to slow increase in length Exhibits relatively constant tension: Smooth muscle tone Amplitude of contraction remains constant although muscle length varies

Smooth Muscle Regulation Innervated by autonomic nervous system Neurotransmitter are acetylcholine and norepinephrine Hormones important as epinephrine and oxytocin Receptors present on plasma membrane which neurotransmitters or hormones bind determines response

Cardiac Muscle Found only in heart Striated Each cell usually has one nucleus Has intercalated disks and gap junctions Autorhythmic cells Action potentials of longer duration and longer refractory period Ca2+ regulates contraction

Effects of Aging on Skeletal Muscle Reduced muscle mass Increased time for muscle to contract in response to nervous stimuli Reduced stamina Increased recovery time Loss of muscle fibers Decreased density of capillaries in muscle

Disorders of Muscle Tissue Cramps Fibromyalgia Hypertrophy & Atrophy Muscular Dystrophy Myasthenia Gravis Tendinitis