Emerge of Crohn’s Disease Incidence in Saudi Arabia; Tertiary Care Centre Experience NA Azzam, A Al-Jebreen, A Abdo, K AI- Suwat, IA Al-Mofleh, RS Al-Rashid, SM AL-Amri, AS Al-Ghamdi, T. Habbal,W AL-Hamoud, M Al Dukhayil Department of medicine, faculty of medicine, king Saud University hospital, Riyadh, Saudi Arabia

Introduction Crohn’s disease is a chronic recurrent inflammatory disorder of the bowel of unknown cause that can affect any part of gastrointestinal tract Crohn’s disease is a chronic recurrent inflammatory disorder of the bowel of unknown cause that can affect any part of gastrointestinal tract

Prevelance of crohn’s

Before 1982, Kirsner and shorter observed that inflammatory bowel disease was rare or non existent in Saudi Arabia Before 1982, Kirsner and shorter observed that inflammatory bowel disease was rare or non existent in Saudi Arabia Kirsner JB, Shorter RG. Recent developments in non-specificinflammatory bowel disease. Kirsner JB, Shorter RG. Recent developments in non-specificinflammatory bowel disease. N Engl J Med 1982; 306: Mokhtar and his group from King Abdul- Mokhtar and his group from King Abdul- Aziz University in Jeddah reported the first two cases of Crohn’s disease in Saudi’s 1982 Aziz University in Jeddah reported the first two cases of Crohn’s disease in Saudi’s 1982 Mokhtar A, Khan MA. Crohn’s disease in Saudi Arabia. Saudi Med J 1982; 3: Mokhtar A, Khan MA. Crohn’s disease in Saudi Arabia. Saudi Med J 1982; 3:

El Sheik et al from Riyadh Armed Force Hospital reported three cases of Crohn’s disease between 1979 and 1985 El Sheik et al from Riyadh Armed Force Hospital reported three cases of Crohn’s disease between 1979 and 1985 El Sheikh MAR, Dip Ven Al Karawi MA, Hamid MA, Yasawy I. Lower gastrointestinal endoscopy. El Sheikh MAR, Dip Ven Al Karawi MA, Hamid MA, Yasawy I. Lower gastrointestinal endoscopy. Ann Saudi Med 1987; 7: Hubler and Isbister from King Faisal Specialist and Research Hospital in Riyadh reported 28 patients with Crohn’s disease between 1976 and 1994 Hubler and Isbister from King Faisal Specialist and Research Hospital in Riyadh reported 28 patients with Crohn’s disease between 1976 and 1994 Hubler M, Isbister W. Inflammatory bowel disease in Saudi Arabia presentation and initial. J Gastroenterol Hepatol 1998;13: Gastroenterol Hepatol 1998;13:

Epidemiology and outcome of Crohn’s disease in a teaching hospital in Riyadh Epidemiology and outcome of Crohn’s disease in a teaching hospital in Riyadh Abdullah S. Al-Ghamdi, Ibrahim A. Al-Mofleh, Rashed S. Al-Rashed, Saleh M. Al-Amri, Abdulrahman M. Aljebreen, World J Gastroenterol 2004;10(9):

retrospective analysis of 77 patients of crohn’s seen for 20 years (between 1983 and 2002). retrospective analysis of 77 patients of crohn’s seen for 20 years (between 1983 and 2002). Abdullah S. Al-Ghamdi, Ibrahim A. Al-Mofleh, Rashed S. Al-Rashed, Saleh M. Al-Amri, Abdulrahman M. Aljebreen, World J Gastroenterol 2004;10(9):

Aim of the study This study aimed to determine the descriptive epidemiology of IBD in single centre in Saudi Arabia by assessing the adult population that suffered from (CD) in KKUH in Riyadh between 2003 to 2005 This study aimed to determine the descriptive epidemiology of IBD in single centre in Saudi Arabia by assessing the adult population that suffered from (CD) in KKUH in Riyadh between 2003 to 2005 compare it with the previously published epidemiology study about CD patient in the same centre from period of compare it with the previously published epidemiology study about CD patient in the same centre from period of

METHODS METHODS Retrospective analysis of 42 CD patients diagnosed (between 2003 and 2005) was performed. Retrospective analysis of 42 CD patients diagnosed (between 2003 and 2005) was performed. Individual case records were reviewed with regard to history, clinical findings, the disease extent, location, clinical pattern, treatment and outcome. Individual case records were reviewed with regard to history, clinical findings, the disease extent, location, clinical pattern, treatment and outcome.

Clinical features of CD patients Age 26.5 y Male 18 (42%) Female 24 (58%) Duration since diagnosis 3 Y Family HX of IBD 3 (7%) Saudi92%

Presenting symptoms Abdominal Pain 41(97%) Diarrhoea40(95%) Bleeding P/R 21(50%) Vomiting14(33%) Fever7(16%) WT loss 21(50%)

Cont… Anemia15(33%) Fistula7(16%) Arthritis1(2%) Eye disease 1(2%) Skin lesion 2(4%) Perianal D 4(9%)

Disease location

CD types

Complications Osteoporosis7(16%) DVT4(9%) Intr Abd Abscess 5(12%) Mal absorption 5(12%) Surgery12(28%) PSC1(2%)

Treatment 5 ASA 29(69%) Imuran34(80%) Prednisone10(23%) Infliximab5(12%) Ciproflaxacin4(9%) Cellcept1(2%)

Result Forty -Two patients with Crohn's disease were reviewed. Forty -Two patients with Crohn's disease were reviewed. The incidence of the CD was increased significant in KKUH from 77 patients diagnosed as Crohn’s disease from ( ) to 42 new patients with CD within ( ) The incidence of the CD was increased significant in KKUH from 77 patients diagnosed as Crohn’s disease from ( ) to 42 new patients with CD within ( ) The patients had more severe disease and more colonic involvement. The patients had more severe disease and more colonic involvement.

Conclusion This study shows an increase in the incidence of CD in Saudi population in tertiary centre especially in the last 3 years This study shows an increase in the incidence of CD in Saudi population in tertiary centre especially in the last 3 years national data registry is needed for the true prevalence of crohn’s diasease in Saudi Arabia national data registry is needed for the true prevalence of crohn’s diasease in Saudi Arabia