Fetal Membranes, Placenta and Twinning Jun Zhou (周俊) School of Medicine, ZheJiang University
Fetal membrane — overview Originate from blastocyst, don’t participate in the formation of embryo Including: 1) Chorion 2) Amnion 3) Yolk sac 4) Allantois 5)Umbilical cord
Chorion Formed by trophoblast +extraembryonic mesoderm Chorion frondosum (bushy chorion)- embryonic pole Chorion laeve (smooth chorion)- abembryonic pole
Development of villi Week 2 to week 3 Primary villi: cytotrophoblast+syncytiotrophoblast Secondary villi: extraembryonic mesoderm enter the primary villi Tertiary villi: extraembryonic mesoderm =>CT+BV
Function of Chorion 1)Exchange of metabolite: portion of placenta (Chorion frondosum) 2) Hormone production: human chorionic gonadotropin (HCG)
Amnion Amniotic membrane : amniotic epi.+ extraembryonic mesoderm Amniotic fluid : Produce:1)amniotic cells 2) infusion of fluid from maternal blood 3) urine output from the fetus 4) pulmonary secretions Output: 1) absorbed by amniotic cells 2) fetus swallow 30 ml weeks 450 ml weeks ml weeks---circulate
Amnion - Fluid Functions Mechanically cushion Protect from fetus adhesion Movement Maintain Temp Abnormalities 1) too much (polyhydramnios) >2000 ml Abnormal digestive system or CNS - esophageal atresia - anencephaly 2) too little (oligohydramnios) <500 ml Abnormal urinary system - poor development of kidney - urethra atresia
Yolk sac and Allantois Yolk sac Primitive Gut 3 rd week, Germ Cells 3 rd to 6 th week, Blood island Allantois Caudal extension of hindgut Allantoic A pairs Allantoic V pairs Umbilical vessels 2A+1V
Umbilical Cord Folding – a purse string closure Amnion membrane covered Cord: mucous CT, 3 vessels,yolk sac,allantois At birth, cm, 2cm diameter Long – knots Short – placenta detachment
Placenta - Overview Functions as: Lungs, GI tract, Liver, Kidneys, Endocrine Placenta proper: Chorion frondosum (fetus)+ Decidua basalis (mother)
Anatomy of the Placenta Fetal – Chorion Chorion Frondosum Chorion Laeva Maternal – Decidua Decidua Basalis Decidua Capsularis Decidua Parietalis
Anatomy of the Placenta At birth 500 g cm Diameter 3 cm thick Anchoring villi Decidual septa Cotyledons
Placental-Fetal Circulation Fetus: umbilical A carries O 2 /nutrient depleted blood to cap. of chorion, exchange with maternal blood of the intervillous space umbilical V Mother: spiral A intervillous space uterine V
Placental Barrier --the structure between fetal and maternal blood --components: 1)endothelium of chorion capillary 2) CT in the core of the villus 3) trophoblast epithelium
Placental Function 1.Exchange of Metabolites: nutrients antibody, waste 2.Defense barrier 3.hormone production human chorionic gonadotropin (HCG) Begin: end of 2 nd week Highest: 2 nd month Estrogen and progesterone Placental lactogen
Twins Two types: One zygote (monozygotic) Two (or more) zygotes (dizygotic) 2 (or more) oocytes Non Identical
Twins - Monozygotic Zygote split 2-4 cell 2 amn, 2 chorion Blastocyst 2 amn, 1 chorion (most common) Bilaminar germ disc 1 amn, 1 chorion (rarely happen) Incomplete splitting Conjoined twins
Conjoined Twins
OBJECTIVES 1.The components of fetal membrane and their functions. 2.Structure and function of placenta 3.Composition of Placenta barrier