Protein kinase networks that limit TLR signalling by Kristopher Clark Biochm. Soc. Trans. Volume 42(1):11-24 February 1, 2014 ©2014 by Portland Press Ltd.

Slides:

Advertisements

Similar presentations

Chapter 5 Ligand gated ion channels, intracellular receptors and phosphorylation cascades.

Advertisements

TNF superfamily TNF: produced by macrophages, monocytes, lymphocytes, fibroblasts upon inflammation, infection, injury, environmental challenges.

Cytoplasmic Signaling Circuitry Programs Many of the Traits of Cancer

B. Signal Transduction Pathway (cell signaling)

FIGURE Calcium ions entering the cytosol from the extracellular medium activate regulated exocytosis in the proximal axon terminal of a pain receptor.

Lecture 04 – Extracellular Signal Receptors II Lecture 04 – Extracellular Signal Receptors II BIOL 5190/6190 Cellular & Molecular Singal Transduction Prepared.

Control levels of transcription factor (TF) activity.

Rho GTPase–phosphatidylinositol phosphate interplay in fungal cell polarity by Robert A. Arkowitz, and Martine Bassilana Biochm. Soc. Trans. Volume 42(1):

Introduction to Signaling Networks Biophysics 702, February 2012 Jonathan P Butchar.

Chapter  Differentiate between the following:  Paracrine  Endocrine  Autocrine.

Please turn in the Unknown Solutions Lab Remember: We will vote on T-shirt designs on Monday.

Toll-Like Receptors (TLR). Toll-Like Receptor Signaling Toll receptor initially discovered in Drosophila as important receptor in dorso-ventral embryonic.

Date of download: 6/21/2016 Copyright © 2016 McGraw-Hill Education. All rights reserved. Cellular signaling pathways for production ofinflammatory cytokines.

Date of download: 7/8/2016 Copyright © 2016 McGraw-Hill Education. All rights reserved. Cellular signaling pathways for production of inflammatory cytokines.

Cellular signaling pathways for production of inflammatory cytokines in response to microbial products. Microbial cell-surface constituents interact with.

Innate immune-signaling cascades and evidence for upregulation in brain following AIE exposure. Innate immune-signaling cascades and evidence for upregulation.

Innate signals in mucosal immunoglobulin class switching

Toll-like receptors: Applications to dermatologic disease

NOD-like and Toll-like receptors or inflammasomes contribute to kidney disease in a canonical and a non-canonical manner Hans-Joachim Anders, Maciej.

Toll Signaling in Flies and Mammals: Two Sorts of MyD88

Toll-like receptors in Borrelia burgdorferi-induced inflammation

Toll-like receptor activation: from renal inflammation to fibrosis

From mesothelioma to cardiovascular protection via the phosphoinositide-3 kinase pathway: A new vista in cardiothoracic surgery Igor E. Konstantinov,

by Walter Zumkeller, and Stefan Burdach

Nat. Rev. Neurol. doi: /nrneurol

Dieter Demon, Lieselotte Vande Walle, Mohamed Lamkanfi

Development of PI3K/AKT/mTOR Pathway Inhibitors and Their Application in Personalized Therapy for Non–Small-Cell Lung Cancer Vassiliki Papadimitrakopoulou,

To the heart of the APS puzzle

Dissecting a Hub for Immune Response: Modeling the Structure of MyD88

Pathogen Recognition and Innate Immunity

Philip P. Ostrowski, Sergio Grinstein, Spencer A. Freeman

Figure 1 The insulin signalling pathway

Jo-Ellen Murphy, Caroline Robert, Thomas S. Kupper

Connecting Mitochondria and Innate Immunity

Volume 146, Issue 7, Pages (June 2014)

Cell Communication (Signaling) Part 3

T Cells Are Smad’ly in Love with Galectin-9

Signal Transduction: RABGEF1 Fingers RAS for Ubiquitination

Figure 2 A model of TNFR–complex I signalling

The cGAS-STING Defense Pathway and Its Counteraction by Viruses

Nanna Fyhrquist, Sampsa Matikainen, Antti Lauerma

Insulin Action under Arrestin

Roles of Caspases in Necrotic Cell Death

Taro Kawai, Shizuo Akira Immunity Volume 34, Issue 5, Pages (May 2011)

Functional Diversity and Regulation of Different Interleukin-1 Receptor-Associated Kinase (IRAK) Family Members Sophie Janssens, Rudi Beyaert Molecular.

Toll Meets Bacterial CpG-DNA

Conspiracy Theory Cell

Toll-like receptors Current Biology

Raquel Espín-Palazón, David Traver Experimental Hematology

Intracellular Toll-like Receptors

Volume 19, Issue 5, Pages (September 2005)

Interleukin signaling

The suppressors of cytokine signaling (SOCS) proteins

Antigen-Receptor Signaling to Nuclear Factor κB

Inflammation NODs to Antagonists of RIP2-XIAP Interaction

Cell Communication (Signaling) Part 3

Innate Recognition of Viruses

Volume 69, Issue 5, Pages (March 2006)

Non-Smad signalling. Non-Smad signalling. The canonical Smad pathway starting from the ligand-receptor complex and ending in the nucleus is illustrated.

Primary immunodeficiencies may reveal potential infectious diseases associated with immune-targeting mAb treatments László Maródi, MD, PhD, Jean-Laurent.

Functional Diversity and Regulation of Different Interleukin-1 Receptor-Associated Kinase (IRAK) Family Members Sophie Janssens, Rudi Beyaert Molecular.

? TLR1-TLR2 TLR1-TLR2L TCR 4-1BB

Macrophages, Immunity, and Metabolic Disease

Different dimerisation mode for TLR4 upon endosomal acidification?

Figure 5 TLR-dependent signaling pathways inhibited by glatiramer acetate Myeloid differentiation primary response gene 88 (MyD88) and Toll-IL-1 receptor.

CD14: Chaperone or Matchmaker?

Signal transduction pathways and activation of the innate immune response. Signal transduction pathways and activation of the innate immune response. In.

Signaling to NF-κB by Toll-like receptors

NF-κB, Inflammation, and Metabolic Disease

Toll-like receptors, adapter proteins, and signaling molecules.

Presentation transcript:

Protein kinase networks that limit TLR signalling by Kristopher Clark Biochm. Soc. Trans. Volume 42(1):11-24 February 1, 2014 ©2014 by Portland Press Ltd

TLR signalling pathways leading to the production of pro-inflammatory cytokines(A) MyD88- dependent signalling pathway. Kristopher Clark Biochm. Soc. Trans. 2014;42:11-24 ©2014 by Portland Press Ltd

Negative regulation of TLR-mediated inflammation by MAPKsThe MAP3K TAK1 is at the head of the MAPK signalling cascade in response to TLR ligands (see Figure 1). Kristopher Clark Biochm. Soc. Trans. 2014;42:11-24 ©2014 by Portland Press Ltd

Regulation of TLR4 signalling by the PI3K pathway(A) Engagement of the TLR4 receptor at the cell surface recruits the adaptor TIRAP, and this interaction is stabilized by the association of TIRAP with PIP2 present on the inner leaf of the plasma membrane. Kristopher Clark Biochm. Soc. Trans. 2014;42:11-24 ©2014 by Portland Press Ltd

Cross-talk within the IKK family(A) Activation of the IKKs. Recruitment of the TAK1 and canonical IKK complexes to polyubiquitin chains leads to the phosphorylation and activation of IKKα and IKKβ by TAK1. Kristopher Clark Biochm. Soc. Trans. 2014;42:11-24 ©2014 by Portland Press Ltd

Control of anti-inflammatory cytokine production by the SIK/CRTC3 signalling cascadeTLR signalling leads to the phosphorylation of CREB at Ser133 driving the production of low levels of the anti-inflammatory cytokine IL-10. Kristopher Clark Biochm. Soc. Trans. 2014;42:11-24 ©2014 by Portland Press Ltd

Early Career Research Award Delivered at the University of York on 17 July 2013 at the Signalling 2013: from Structure to Function Focused MeetingKristopher Clark. Kristopher Clark Biochm. Soc. Trans. 2014;42:11-24 ©2014 by Portland Press Ltd