Long-Term Complications and Mortality in Young-Onset Diabetes Type 2 diabetes is more hazardous and lethal than type 1 diabetes Featured Article: Maria.

Slides:

Advertisements

Similar presentations

Surgery volume and operative mortality: A re-examination using fixed-effects regression Amresh Hanchate, PhD Section of General Internal Medicine Boston.

Advertisements

© 2010, American Heart Association. All rights reserved. A Validated Risk Score for In-hospital Mortality in Patients with Heart Failure from the American.

The Effect of Serotype on Early and Late Mortality in Invasive Pneumococcal Disease in Hull and East Yorkshire Chloe Walsh ACF infectious diseases.

Does Preoperative Hemoglobin Value Predict Postoperative Cardiovascular Complications after Total Joint Arthroplasty? Kishor Gandhi MD, MPH, Eugene Viscusi.

Effects of Gastric Bypass Surgery in Patients With Type 2 Diabetes and Only Mild Obesity Featured Article: Ricardo V. Cohen, M.D., Jose C. Pinheiro, M.D.,

Journal Club Alcohol, Other Drugs, and Health: Current Evidence May–June 2010.

Journal Club Alcohol, Other Drugs, and Health: Current Evidence September-October 2007.

Journal Club Alcohol, Other Drugs, and Health: Current Evidence March–April 2010.

Journal Club Alcohol and Health: Current Evidence July–August 2004.

Severe Hypoglycemia and Mortality After Cardiovascular Events for Type 1 Diabetic Patients in Sweden Featured Article: Tom W.C. Lung, Dennis Petrie, William.

Incretin-Based Drugs and the Risk of Congestive Heart Failure Featured Article: Oriana Hoi Yun Yu, Kristian B. Filion, Laurent Azoulay, Valerie Patenaude,

Is There a Link Between Liraglutide and Pancreatitis? A Post Hoc Review of Pooled and Patient-Level Data From Completed Liraglutide Type 2 Diabetes Clinical.

Reference Cooper BA, and the IDEAL study group. A randomized controlled trial of early versus late initiation of dialysis. N Engl J Med [Accessed.

Edward P. Sloan, MD, MPH, FACEP EMRA /FERNE Case Conference: The ED Management of TIA, AIS and ICH Patients.

Vitamin D Levels Predict All-Cause and Cardiovascular Disease Mortality in Subjects With the Metabolic Syndrome Featured Article: G. Neil Thomas, Ph.D.,

1 National trends in rates of death and hospital admissions related to acute myocardial infarction, heart failure and stroke, 1994–2004 CIHR Team Grant.

An Automated Internet Behavioral Weight-Loss Program by Physician Referral: A Randomized Controlled Trial Featured Article: J. Graham Thomas, Tricia M.

1 Journal Club Alcohol, Other Drugs, and Health: Current Evidence July–August 2012.

Clinical Impact of Adherence to Pharmacotherapeutic Guidelines on the Outcome in Patients with Chronic Heart Failure Suntheep Batra, M.Pharm Department.

Research Techniques Made Simple: Databases for Clinical Research Katrina Abuabara, MD MA David Margolis, MD PhD University of Pennsylvania.

Randomized, double-blind, multicenter, controlled trial.

Individualizing Targets and Tactics for High- Risk Patients With Type 2 Diabetes Practical lessons from ACCORD and other cardiovascular trials Featured.

Complete Recovery of Renal Function After Acute Kidney Injury is Associated with Long-Term All-Cause Mortality In a Large Managed Care Organization Jennifer.

Microvascular Complications in Childhood- Onset Type 1 Diabetes and Celiac Disease: A Multicenter Longitudinal Analysis of 56,514 Patients From the German-Austrian.

Cognitive Impairment: An Independent Predictor of Excess Mortality SACHS, CARTER, HOLTZ, ET AL. ANN INTERN MED, SEP, 2011;155: ZACHARY LAPAQUETTE.

Cardiovascular Disease & Mortality in Diabetes Stephen Fava MD, MRCP(UK), FEFIM, FACP, FRCP (Lond), MPhil (Malta), PhD (Exeter) Consultant Physician, Diabetologist.

Independent Association Between Obstructive Sleep Apnea Severity and Glycated Hemoglobin in Adults Without Diabetes Featured Article: Pascaline Priou,

Antibiotics Versus Conservative Surgery for Treating Diabetic Foot Osteomyelitis: A Randomized Comparative Trial Featured Article: José Luis Lázaro-Martínez,

Impact of Socioeconomic Status on Cardiovascular Disease and Mortality in 24,947 Individuals With Type 1 Diabetes Featured Article: Araz Rawshani, Ann-Marie.

The ADVANCE trial: update and new results Jean-François Gautier Saint Louis Hospital, Paris 12 th Meeting of the Mediterranean Group for the Study of Diabetes.

Ethnic Differences in the Prognostic Value of Coronary Artery Calcification for All-Cause Mortality Khurram Nasir MD MPH, Leslee J. Shaw PhD, Sandy T.

Long-term mortality after acute stroke  Stroke is a leading cause of mortality: 6 million fatal events annually worldwide.  Mainly affects elderly, but.

Published in Circulation 2003 Rory Hachamovitch, MD, MSc; Sean W. Hayes, MD; John D. Friedman, MD; Ishac Cohen PhD; Daniel S. Berman, MD Comparison of.

Individualization Strategies for Older Patients with Diabetes Elbert S. Huang, MD MPH FACP University of Chicago.

Top Papers in Critical Care 2013 Janna Landsperger RN, MSN, ACNP-BC.

Early Loss of the Glucagon Response to Hypoglycemia in Adolescents With Type 1 Diabetes Featured Article: Aris Siafarikas, F.R.A.C.P., M.D., Robert J.

Risk of Dementia in Seniors with Newly Diagnosed Diabetes: A Population-Based Study Featured Article: Nisha Nigil Haroon, Peter C. Austin, Baiju R. Shah,

Retinal Vascular Geometry Predicts Incident Renal Dysfunction in Young People with Type 1 Diabetes Featured Article: Paul Z. Benitez-Aguirre, M.P.H., FRACP.,

Dr Sam Ley CT2 ICM Dr Radha Sundaram Consultant ICM Royal Alexandra Hospital, Paisley, Scotland.

Risk Factors for Decline in IQ in Youth With Type 1 Diabetes Over the 12 Years From Diagnosis/Illness Onset Featured Article: Ashleigh Lin, Elisabeth A.

A Claims Database Approach to Evaluating Cardiovascular Safety of ADHD Medications A. J. Allen, M.D., Ph.D. Child Psychiatrist, Pharmacologist Global Medical.

Retinopathy in Youth With Type 2 Diabetes Participating in the TODAY Clinical Trial Featured Article: TODAY Study Group* Diabetes Care Volume 36:

Diabetes and Cause-Specific Mortality in a Prospective Cohort of One Million U.S. Adults Featured Article: Peter T. Campbell, Ph.D., Christina C. Newton,

Evaluation of Current Eligibility Criteria for Bariatric Surgery Diabetes prevention and risk factor changes in the Swedish Obese Subjects (SOS) study.

1 CONFIDENTIAL – DO NOT DISTRIBUTE ARIES mCRC: Effectiveness and Safety of 1st- and 2nd-line Bevacizumab Treatment in Elderly Patients Mark Kozloff, MD.

Clinical and Economic Benefits Associated With the Achievement of Both HbA1c and LDL Cholesterol Goals in Veterans With Type 2 Diabetes Featured Article:

Childhood and Adult Secondhand Smoke and Type 2 Diabetes in Women Featured Article: Martin Lajous, M.D., S.C.D., Laura Tondeur, M.S., Guy Fagherazzi, P.H.D.,

Prognostic Accuracy of Immunologic and Metabolic Markers for Type 1 Diabetes in a High-Risk Population: Receiver Operating Characteristic Analysis Featured.

Trends in Death Rates Among U.S. Adults With and Without Diabetes Between 1997 and 2006 Featured Article: Edward W. Gregg, Ph.D., Yiling J. Cheng, Ph.D.,

Mortality After Incident Cancer in People With and Without Type 2 Diabetes Featured Article: Craig J. Currie, Ph.D., Chris D. Poole, Ph.D., Sara Jenkins-Jones,

Genetic Risk Score Constructed Using 14 Susceptibility Alleles for Type 2 Diabetes Is Associated With the Early Onset of Diabetes and May Predict the Future.

High Concentrations of AGE-LDL and Oxidized LDL in Circulating Immune Complexes Are Associated With Progression of Retinopathy in Type 1 Diabetes Featured.

Short- and Long-Term Mortality After Myocardial Infarction in Patients With and Without Diabetes Featured Article: Sjoerd T. Nauta, M.S.C., Jaap W. Deckers,

R1 강민혜 / prof. 전숙. Introduction Patients with type 2 diabetes have a greatly increased risk of cardiovascular events. The morbidity and mortality related.

Is it possible to predict New Onset Diabetes After Transplantation (NODAT) in renal recipients using epidemiological data alone? Background NODAT is an.

Celiac Disease Increases Risk of Thyroid Disease in Patients With Type 1 Diabetes: A Nationwide Cohort Study Featured Article: Matthew Kurien, Kaziwe Mollazadegan,

Severe Hypoglycemia Identifies Vulnerable Patients With Type 2 Diabetes at Risk for Premature Death and All-Site Cancer: The Hong Kong Diabetes Registry.

Type 2 Diabetes With Partial Lipodystrophy of the Limbs A new lipodystrophy phenotype Featured Article: Leah R. Strickland, B.S., Fangjian Guo, M.D., Kerry.

LEADER trial: Primary Outcome

Alcoholic liver disease in intensive care

Diabetes Journal Club March 17, 2011

Daniel Lessler, MD, MHA Chief Medical Officer Health Care Authority

Cumulative incidence of (A) ESRD, (B) all-cause death, (C) all-cause death without ESRD and (D) ESRD or all-cause death in patients with T1DM diagnosed.

Extubating in the operating room after adult cardiac surgery safely improves outcomes and lowers costs Vinay Badhwar, MD, Stephen Esper, MD, Maria Brooks,

Effects of Pay-for-Performance on the Quality of Primary Care in England Mean Scores for Clinical Quality at the Practice Level for Aspects of Care for.

EMPA-REG OUTCOME: Cumulative incidence of the primary outcome

Recurrent Vascular Access Dysfunction as a Novel Marker of Cardiovascular Outcome and Mortality in Hemodialysis Patients Kim et al. Am J Nephrol 2016;44:71-80.

Prevalence of clinically significant microvascular (green) and clinically significant macrovascular (yellow) disease alone and combined microvascular and.

Morbidity and mortality benefits with statin use in observational studies on a logarithmic scale. Morbidity and mortality benefits with statin use in observational.

Alcohol, Other Drugs, and Health: Current Evidence

Presentation transcript:

Long-Term Complications and Mortality in Young-Onset Diabetes Type 2 diabetes is more hazardous and lethal than type 1 diabetes Featured Article: Maria I. Constantino, BInfoTech, Lynda Molyneaux, R.N., Frankziska Limacher- Gisler, MClinTPrac, Abdulghani Al-Saeed, M.D., Connie Luo, R.N., Ted Wu, M.D., P.H.D., Stephen M. Twigg, M.D., P.H.D., Dennis K. Yue, M.D., P.H.D., Jencia Wong, M.D., P.H.D. Diabetes Care Volume 36: December, 2013

STUDY OBJECTIVE To evaluate long-term clinical outcomes and survival in young-onset type 2 diabetes (T2DM) compared with type 1 diabetes (T1DM) with a similar age of onset Constantino M. I. et al. Diabetes Care 2013;36:

STUDY DESIGN AND METHODS Records from the Royal Prince Alfred Hospital Diabetes Clinical Database were matched with the Australian National Death Index Mortality outcomes for all subjects until June 2011 were established Clinical and mortality outcomes in 354 patients with T2DM, age of onset between 15 and 30 years (T2DM15–30), were compared with T1DM Primary comparison was with 470 patients with T1DM with a similar age of onset (T1DM15–30) to minimize the confounding effect of age on outcome Constantino M. I. et al. Diabetes Care 2013;36:

RESULTS Median observation period was 21.4 (interquartile range 14– 30.7) and 23.4 (15.7–32.4) years for the T2DM and T1DM cohorts, respectively 71 of 824 patients (8.6%) died A significant mortality excess was noted in T2DM15–30 with an increased hazard for death Constantino M. I. et al. Diabetes Care 2013;36:

RESULTS Death for T2DM15–30 occurred after a significantly shorter disease duration and at a relatively young age There were more cardiovascular deaths in T2DM15–30 Albuminuria and less favorable cardiovascular risk factors were greater in T2DM15–30 Neuropathy scores and macrovascular complications were also increased in T2DM15–30 Constantino M. I. et al. Diabetes Care 2013;36:

CONCLUSIONS Compared with T1DM, young-onset T2DM is the more lethal phenotype of diabetes and is associated with: Greater mortality More diabetes complications Unfavorable cardiovascular disease risk factors Constantino M. I. et al. Diabetes Care 2013;36: