DNA nanotechnology: Geometric sorting boards David W. Grainger Nature Nanotechnology 4, 543 - 544 (2009) Speaker：Zong-Han Li Instructor: Kun-Mao Chao 2012/6/4

Outline Geometrical self-assembly DNA Origami Surface patterning with DNA tiles DNA tiny chips Geometrical self-assembly 2012/6/4

DNA Origami A: single-stranded DNA and staple strands. B: Design of a self- assembled DNA origami structure and geometry of the incorporated double-stranded DNAs. Endo, M. and Sugiyama, H. 2011. Recent Progress in DNA Origami Technology. Current Protocols in Nucleic Acid Chemistry. 45:12.8.1–12.8.19. 2012/6/4

Surface patterning with DNA tiles. a:Nanoscale DNA tiles b:DNA tiles decorated with different functional reagents are used to create a variety of functional devices from a mixed solution of tiles. David W. Grainger Nature Nanotechnology 4, 543 - 544 (2009) doi:10.1038/nnano.2009.249 2012/6/4

DNA tiny chips 6nm DNA Origami for Faster, Smaller Computer Chips R. J. Kershner et al Nature Nanotechnology 4, 557 - 561 (2009)  6nm DNA Origami for Faster, Smaller Computer Chips IBM suggests that it could take up to 10 years to test and refine the process for manufacturing. Tiny, triangular DNA structures self-assemble on silicon. Credit: IBM 2012/6/4

Geometrical self-assembly Attractive interactions between DNA origami tiles are coded in their complementary shaped edges, recapitulating the binding of complementary sequences of bases to form a DNA double helix. DNA nanotechnology: Geometrical self-assembly Andrew J. Turberfield Nature Chemistry 3, 580–581 (2011) doi:10.1038/nchem.1097 2012/6/4

Thanks for your attention 2012/6/4