Combination Therapy Research of Curcumin Micellar Prodrug Encapsulated with Paclitaxel Name : Qi Zhang No. : 2011213027 Tutor : Zheng Wang.

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Combination Therapy Research of Curcumin Micellar Prodrug Encapsulated with Paclitaxel Name : Qi Zhang No. : Tutor : Zheng Wang

Contents Introduction Proposals Current experiment Schedules for the next stage References

Introduction Advantages: antioxidant \ antitumor activity low toxicity \ less adverse reactions Disadvantages: unstable \ low water solubility low bioavailability Advantages: high antitumor activities Disadvantages: severe side effect low water solubility

Proposal Micelle formation Characterization Drug loading and releasing Investigation on stability In vitro antitumor activity

Current experiment

1 H-NMR

MPEG-PLA-Tris-Cur 图接枝率 : 1.95 左右

Micelle formation dialysis Self-assemble Paclitaxel (different ratio) MPEG-PLA-Tris-curcumin micelle MPEG-PLA-Tris-curcumin/pax micelle 15 : 1 10 : : 2 10 : 3

TEM Void micelle

Size SampleSize 空白胶束 98.6 载体 / 胶束（ 15/1 ）载体 / 胶束（ 10/1.5 ）载体 / 胶束（ 10/2 ）载体 / 胶束（ 10/3 ） 124.9

Schedules for the next stage Drug loading and releasing Investigation on stability In vitro antitumor activity

References Y. Q. Shen, E. Jin, et al., Prodrugs forming high drug-loading multifunctional nanocapsules for cancer intracellular drug delivery, J. Am. Chem. Soc. 2010, 132: 4259–4265. H. D. Tang, C. J. Murphy, B. Zhang, et al., Amphiphilic curcumin conjugate- forming nanoparticles as anticancer prodrug and drug carriers: in vitro and in vivo effects, Nanomedicine 2010, 5(6): Y. Qiao, P. S. Rong, D. Zhuo, Preparation and properties of self-assemble paclitaxel-loaded core-shell type nano-micelles, Acta Pharmaceutica Sinica 2008, 43(4): X. F. Zhang, Y. X. Li, X. S. Chen, et al., Synthesis and characterization of the paclitaxel/MPEG-PLA block copolymer conjugate, Biomaterials 2005, 26: Z. Ma, A. Haddadi, et al., Micelles of poly(ethylene oxide)-b-poly(e- caprolactone) as vehicles for the solubilization, stabilization,and controlled delivery of curcumin, Journal of Biomedical Materials 2007, 10: