1. Laboratoire d'Automatique et de Génie des Procédés
LAGEP
Laboratoire d'Automatique et de Génie des Procédés
Université Claude Bernard Lyon 1 and CNRS
UMR 5007

2. GEPHARM: Génie Pharmacotechnique
New pharmaceutical dosage forms
Design and development of drug delivery systems (nanoparticles, nanocapsules, nanoemulsions, liposomes etc..)
Development of manufacturing processes
Nano and microencapsulation
Conventional forms (tablets, capsules…)
Biopharmacy
Oral, parenteral and topic (skin penetration and absorption control) administration
Diagnostic tools
Particules functionalisation and biomolecules association (protéines – virus)
Preparation methods : emulsions step / precipitation
Emusification processes : mechanical energy, ultra-sounds, high pressure homogeneisation, membranes processes

3. Revert immunosuppression Long lasting drug activity
Different nanocarrier prototypes
Increase solubility of drugs and protect genetic material
Possibility of functionalization with specific ligands
Possibility to chose the administration route
Improve in vitro and in vivo stability
Nano-immuno medicine :
ongoing projects
Vaccine Delivery
Gemcitabine
loaded LNC
MDSC
Revert immunosuppression
Paclitaxel
Retinoic acid
Calcitriol
Long lasting drug activity
Melanoma (B16) expresses the telomerase reverse transcriptase TERT. The ACT for melanoma is composed of T cells targeting TERT.
TERT-specific T cells were obtained from a mixed-leukocyte peptide culture set up with splenocytes obtained from vaccinated mice
1-Lollo et al. Polyarginine Nanocapsules as a Potential Oral Peptide Delivery Carrier.J Pharm Sci. 2017
2-Sasso et al., Low dose gemcitabine-loaded lipid nanocapsules target monocytic myeloid-derived suppressor cells and potentiate cancer immunotherapy. Biomaterials 2016
3-Lollo G et al. Development of multifunctional lipid nanocapsules for the co-delivery of paclitaxel and CpG-ODN in the treatment of glioblastoma. Int J Pharm. 2015

4. GEPHARM: Génie Pharmacotechnique
BIOTOP platform
Bioproduction, Freeze-drying
Pharmaceutical dosage form
Physico-chemistry
platform
Micrometrics, rheology,
Interfacial studies…
Scale-up
platform
IMTHERNAT :
Imagerie Moléculaire et THERapeutique à
base de Nanoparticules et/ou de Traceurs
SPECT-CT, Imagerie Bioluminescence fluorescence
Radiomarquage des NP ou cellules- Biodistribution des Nanoparticules 4