Targeting Robo4-Dependent Slit Signaling to Survive the Cytokine Storm in Sepsis and Influenza by Nyall R. London, Weiquan Zhu, Fernando A. Bozza, Matthew.

Slides:

Advertisements

Similar presentations

Therapeutic Intervention of Ebola Virus Infection in Rhesus Macaques with the MB-003 Monoclonal Antibody Cocktail by James Pettitt, Larry Zeitlin, Do H.

Advertisements

T Cells with Chimeric Antigen Receptors Have Potent Antitumor Effects and Can Establish Memory in Patients with Advanced Leukemia by Michael Kalos, Bruce.

Conserved Shifts in the Gut Microbiota Due to Gastric Bypass Reduce Host Weight and Adiposity by Alice P. Liou, Melissa Paziuk, Jesus-Mario Luevano, Sriram.

MicroRNA Inhibition of Translation Initiation in Vitro by Targeting the Cap-Binding Complex eIF4F Nahum Sonenberg et al. Science, September 2007 Presentation.

Successful Treatment of Ebola Virus–Infected Cynomolgus Macaques with Monoclonal Antibodies by Xiangguo Qiu, Jonathan Audet, Gary Wong, Stephane Pillet,

Immune Parameters Correlate with Protection Against Ebola Virus Infection in Rodents and Nonhuman Primates by Gary Wong, Jason S. Richardson, Stéphane.

Productive Replication of Ebola Virus Is Regulated by the c-Abl1 Tyrosine Kinase by Mayra García, Arik Cooper, Wei Shi, William Bornmann, Ricardo Carrion,

First-in-Human Testing of a Wirelessly Controlled Drug Delivery Microchip by Robert Farra, Norman F. Sheppard, Laura McCabe, Robert M. Neer, James M. Anderson,

Genotypic and Histological Evolution of Lung Cancers Acquiring Resistance to EGFR Inhibitors by Lecia V. Sequist, Belinda A. Waltman, Dora Dias-Santagata,

Scanning ultrasound removes amyloid-β and restores memory in an Alzheimer’s disease mouse model by Gerhard Leinenga, and Jürgen Götz Sci Transl Med Volume.

The Effect of Diet on the Human Gut Microbiome: A Metagenomic Analysis in Humanized Gnotobiotic Mice by Peter J. Turnbaugh, Vanessa K. Ridaura, Jeremiah.

Fig. 1. TP is highly expressed in myeloma.

Fig. 2. Effects of AZD4785 on proliferation and MAPK pathway signaling in KRAS mutant and wild-type cancer cells in vitro. Effects of AZD4785 on proliferation.

Fig. 1. Potent and selective down-regulation of KRAS mRNA and protein by AZD4785 in vitro and in vivo. Potent and selective down-regulation of KRAS mRNA.

Transfer of miR-223 during neutrophil-epithelial cell interactions

In vivo function of MeTro sealants using rat incision model of lungs

Fig. 8. Gene and protein changes in ALK-dependent STING pathways in human sepsis. Gene and protein changes in ALK-dependent STING pathways in human sepsis.

Fig. 3. Antimicrobial activity is detected in diverse strains of CoNS and not predictable at the species level. Antimicrobial activity is detected in diverse.

Fig. 2 miRNA181a targets NFAT5 in human CD4+ T cells.

In vivo prophylactic and therapeutic efficacy of C12G6 in mice

Comment on “Impacts of species richness on productivity in a large-scale subtropical forest experiment” by Hua Yang, Zhongling Guo, Xiuli Chu, Rongzhou.

Fig. 2. In vitro profiling of tEV markers on cell line–derived EVs.

Fig. 4. Biomechanical properties of treated tibiae.

Fig. 1 Crohn’s disease association within the LRRK2 locus.

Fig. 2 Maraba treatment results in complete responses in the window of opportunity setting. Maraba treatment results in complete responses in the window.

Fig. 6 Bimodal treatment results in reduced tinnitus loudness and reduced TFI scores in human patients. Bimodal treatment results in reduced tinnitus loudness.

Fig. 4. Physical properties of HB.

Fig. 8. mRIPO elicits neutrophil influx followed by DC and T cell infiltration into tumors. mRIPO elicits neutrophil influx followed by DC and T cell infiltration.

Maraba treatment sensitizes 4T1 tumors to immune checkpoint blockade

Fig. 2. GPC3 expression in normal and tumor tissues.

Bio-AMS enhances the activity of rifampicin and ethambutol in vitro

Increased ADMA in pregnancy is associated with SGA birth outcomes

Fig. 5. Pharmacological JAK2 inhibition in vivo abrogates tumor-initiating potential after chemotherapy. Pharmacological JAK2 inhibition in vivo abrogates.

Fig. 5. Vascularization of human liver seed grafts.

Fig. 1. CD31 is present throughout the human renal vasculature.

Fig. 7 Gel scaffold for inhibition of postsurgical recurrence of B16F10 tumors. Gel scaffold for inhibition of postsurgical recurrence of B16F10 tumors.

Fig. 5 Combination intravenous reovirus and checkpoint inhibition in an orthotopic syngeneic brain tumor model. Combination intravenous reovirus and checkpoint.

Fig. 4. MATE1 transcription in RCC.

Fig. 2. Best model fits. Best model fits. Illustration of the best model fits for the (A) basic, (B) continuous, and (C) cluster models. See Table 1 and.

Fig. 6. Apoptotic MSCs exert in vivo immunosuppression in a TH2-type inflammation model in the absence of cytotoxic cells. Apoptotic MSCs exert in vivo.

Fig. 5 Hypoxic tumors from obese mice associate with increased production of IL-6 by adipocytes and myeloid cells. Hypoxic tumors from obese mice associate.

Fig. 4. BET inhibition sensitizes HR-proficient tumors to PARPi treatment in vivo. BET inhibition sensitizes HR-proficient tumors to PARPi treatment in.

Fig. 4. BLU-285 demonstrates antitumor activity across multiple KIT-driven in vivo disease models. BLU-285 demonstrates antitumor activity across multiple.

Fig. 8 SOD2 overexpression in normal tissues does not compromise the cytotoxic efficacy of RT. SOD2 overexpression in normal tissues does not compromise.

Persistence of CAR4 cells is reduced after sustained TCR engagement

Fig. 7 Human study design for device testing.

Antiproliferative effects of JQ-EZ-05 on VHL−/− ccRCC are on-target

Fig. 2 Whisker deprivation accelerates and enhances behavioral recovery after right S1FP photothrombosis. Whisker deprivation accelerates and enhances.

Fig. 1. Map showing the study catchment area in the East of England.

Fig. 5. Nutlin-3 treatment rescues the proliferation and differentiation of NPCs in vitro. Nutlin-3 treatment rescues the proliferation and differentiation.

HECTD2 knockdown ameliorates Pseudomonas-induced lung injury in vivo

Fig. 7. Genetic ablation of UCP2 compromised the protective effect of exogenous irisin on lung IR injury. Genetic ablation of UCP2 compromised the protective.

Fig. 2. IONP characterization.

Fig. 4. The effect of single-dose rozanolixizumab on the concentration of IgG subtypes in healthy subjects. The effect of single-dose rozanolixizumab on.

Fig. 6. Analysis of SHIV-325c V1V2 envelope sequences in breakthrough infections. Analysis of SHIV-325c V1V2 envelope sequences in breakthrough infections.

CD facilitates RCT in vivo and promotes urinary cholesterol excretion

Fig. 1. In vivo fates of patient-derived AML cells defined by mutational profile. In vivo fates of patient-derived AML cells defined by mutational profile.

Stroke induces inflammatory activation of the aortic endothelium

Fig. 7 Analysis of the bacterial nidus within tissue abscesses by MALDI IMS demonstrates a paucity of calprotectin signal. Analysis of the bacterial nidus.

Fig. 2 Activation of freshly isolated CD4+ T cells from HIV-infected patients on ART results in successive increases in elongated, polyadenylated, and.

Fig. 7 Vaccine-induced influenza-specific B cells are not maintained in peripheral blood. Vaccine-induced influenza-specific B cells are not maintained.

IIV induces CD21hiCD27+ and CD21loCD27+ influenza-specific B cells

Fig. 3 Activation of freshly isolated CD4+ T cells from HIV-infected patients on ART selectively reverses baseline blocks to splicing, elongation, and.

Fig. 2. BET inhibition enhances PARPi-induced DNA damage.

Fig. 8. Zbtb7a deficiency impairs antigen presentation by AMs.

Fig. 7 Transient immunosuppression (4 weeks) supports long-term graft survival and is associated with progressive decrease in spinal regional inflammatory.

Fig. 6 In utero injection of inflammatory cytokines or adoptive transfer of activated T cells leads to pregnancy loss. In utero injection of inflammatory.

HECTD2 knockdown ameliorates Pseudomonas-induced lung injury in vivo

Fig. 1. CAR4 and CAR8 cells demonstrate in vitro and in vivo antileukemic efficacy. CAR4 and CAR8 cells demonstrate in vitro and in vivo antileukemic efficacy.

Fig. 3. Association between peak CTL019 expansion and response.

Presentation transcript:

Targeting Robo4-Dependent Slit Signaling to Survive the Cytokine Storm in Sepsis and Influenza by Nyall R. London, Weiquan Zhu, Fernando A. Bozza, Matthew C. P. Smith, Daniel M. Greif, Lise K. Sorensen, Luming Chen, Yuuki Kaminoh, Aubrey C. Chan, Samuel F. Passi, Craig W. Day, Dale L. Barnard, Guy A. Zimmerman, Mark A. Krasnow, and Dean Y. Li Sci Transl Med Volume 2(23):23ra19-23ra19 March 17, 2010 Published by AAAS

Fig. 1 Slit2N stabilizes the endothelium in vitro by enhancing VE-cadherin localization at the cell surface. Nyall R. London et al., Sci Transl Med 2010;2:23ra19 Published by AAAS

Fig. 2 Slit2N enhances a VE-cadherin–p120-catenin interaction in vitro. Nyall R. London et al., Sci Transl Med 2010;2:23ra19 Published by AAAS

Fig. 3 Slit2N inhibits LPS-induced permeability, protein exudates, and cell infiltrates in vivo. Nyall R. London et al., Sci Transl Med 2010;2:23ra19 Published by AAAS

Fig. 4 Slit2N reduces permeability and mortality in a CLP model of sepsis. Nyall R. London et al., Sci Transl Med 2010;2:23ra19 Published by AAAS

Fig. 5 Slit2N reduces mortality in models of H5N1 infection. Nyall R. London et al., Sci Transl Med 2010;2:23ra19 Published by AAAS

Fig. 6 Slit reduces vascular leak caused by multiple inflammatory stimuli through enhancing VE- cadherin at the cell surface. Nyall R. London et al., Sci Transl Med 2010;2:23ra19 Published by AAAS