Uterine Cancer Endometrial (or uterine) cancer will account for 50,000 new cases and 8200 deaths in the United States in 2013. Two genetic disorders are.

Slides:

Advertisements

Similar presentations

Colon Cancer The life time risk of developing Colon Cancer in the United States in one in sixteen. This means 144,000 new cases a year accounting for.

Advertisements

© 2009 NHS National Genetics Education and Development CentreGenetics and Genomics for Healthcare This PowerPoint file contains.

This short questionnaire will help to determine whether there may be a gene in your family connected to an increased risk of the development of bowel.

Kate Thomson Molecular Genetics Laboratory, Oxford

Hereditary GI Cancer Syndromes: Keys to identify high risk patients

Cancer: a genetic disease of inherited and somatic mutations n Gene mutations and/or genetic instability are involved in many cancers. n Viruses and environmental.

Diamond Blackfan Anaemia Yvonne Harrington DBA conference 15 th November 2014.

Lynch Syndrome and Colorectal Cancer Steven G. Proshan, M.D. Annapolis Colon and Rectal Surgeons Anne Arundel Medical Center November 8,

A few thoughts on cancer and cancer family syndromes Pamela McGrann, MD. Department of Medical Genetics.

Understanding Hereditary Cancers Brittany Burnett, MS, CGC Certified Genetic Counselor John Muir/Mt. Diablo Health System Cancer Centers.

© 2001 Myriad Genetic Laboratories Northern Nevada Genetic Counseling Robbin Palmer Certified Genetic Counselor

Hereditary Colorectal Cancer: An Overview Felice Schnoll-Sussman,MD Jay Monahan Center for Gastrointestinal Health New York Hospital/ Weill Cornell Medical.

Breast Cancer Risk and Risk Assessment Models

Familial Colorectal Cancers Francis M. Giardiello, M.D. The Johns Hopkins University.

Comprehensive IHC Screening for Lynch Syndrome: What You Need to Know Andrea Lewis, MS, CGC January 14, 2010.

Morning Report May 20, 2009 Bridger Clarke  Born in Lawrence, Massachusetts, on 4 January  Dropped out of high school at the age of fourteen.

SURVIVORS TEACHING STUDENTS: SAVING WOMEN’S LIVES®

Introduction to Cancer Genetics and Genomics Apostolos Psychogios, MD, FACMG Associate Professor of Pediatrics LeeAnne Brown Chair of Clinical Excellence.

Cancer Genetics for Primary Care Sara Levene Registered Genetic Counsellor.

The Loss of the Cell Cycle Control in Cancer

Clinical Applications of Genetic Tests Mikenzie Lewis.

Genetic Screening for Cystic Fibrosis A New Choice for You and Your pregnancy.

BRCA Mutations and Breast Cancer Ruth Phillips and Patty Ashby.

Breast Screening. NHS Breast Screening Programme Introduced in 1988 Invites women from age group for screening every 3 yrs. Age extension roll-out.

Immunohistochemistry (IHC) for Microsatellite Instability Fact Sheet Frequently Asked Questions What is Lynch Syndrome? Lynch syndrome is a hereditary.

Genetics & Colorectal Cancer

Cancer Genetics Genetic Disorder. What are cancer genetics? Many cancer-predisposing traits are inherited in an autosomal dominant fashion, that is, the.

Genetics and Ovarian Cancer June 16, 2015 Ovarian Cancer Alliance of Oregon and SW Washington Becky Clark, MS, CGC Genetic Counselor.

Your Family Health History

Genomics Alexandra Hayes. Genomics is the study of all the genes in a person, as well as the interactions of those genes with each other and a person’s.

Early Detection Is Your Best Protection. Breast Cancer Statistics for Women A woman has a one in eight chance of developing breast cancer in her lifetime.

GENETIC TESTING: WHAT DOES IT REALLY TELL YOU? Lori L. Ballinger, MS, CGC Licensed Genetic Counselor University of New Mexico Cancer Center.

Angelina Jolie The White Coat Wonder. Rational  The purpose of our research is to enrich the Premed-A community with the knowledge of other cancers caused.

Carisa Sanborn and Nikita Meshwani. PATIENTS  People who want to learn about their birth defects  Women who want to know if their children will have.

 Cancer is a group of more than 100 diseases that develop over time › Involve the uncontrolled division of the body’s cells  Cancer is the 2 nd leading.

Amber Ellis and Russell Brown

Tumour Analysis-Lynch Syndrome Dr Alan Donaldson Consultant in Clinical Genetics Bristol.

Ovarian Cancer Risk Reduction Taking oral contraceptives for 5 years can reduce your risk of ovarian cancer by up to 50% Hankinson SE, Colditz GA, Hunter.

Chapter 11.3 Pg  Pairs of homologous chromosomes are arranged in decreasing size to produce a micrograph called a karyotype  Scientists have found.

Shiva Sharma SHO to Professor Redmond.  Introduction  Increased risk groups  Consideration of genetic testing  Management of patients with mutation.

BRCA1 and BRCA2 are genes which normally help to prevent breast cancer by making proteins which inhibit abnormal cellular growth. While a woman with an.

CASE #574321F – The Ford Family

Understanding Cancer and Related Topics

Failure to appropriately screen women according to international guidelines– what are the consequences? Alison Johnston*, M Sugrue, S Curran Department.

Prostate Cancer There are roughly 240,000 cases of prostate cancer diagnosed in the United States each year, making it the most common cancer in males.

University Hospitals Portage Medical Center. Portage County has one of the highest annual incidence rates of bladder cancer in the state of Ohio. According.

Pancreatic Cancer In 2012 there were 43,920 cases of pancreatic cancer. 10% of these cases have a family clustering of pancreatic cancers and associated.

Regulating the Cell Cycle the cell cycle has a built-in genetic signals to tell cells when to start and stop dividing –proto-onco genes – genes that encourage.

Breast Cancer Ten percent of breast cancer is hereditary. Or 23,000 women a year with a genetic basis for their cancer. The most common mutations in this.

Talking to Your Family About Your Diagnosis of Lynch Syndrome When you share information with people, sometimes they feel helpless and don’t want to address.

Do you have 3 or more affected relatives? (2 or less)

Cancer Genetic Counseling and Familial Cancer Risk Assessment Program Zohra Ali-Khan Catts, MS LCGC Helen F. Graham Cancer Center Christiana Care Health.

Genetic Counseling Yahwardiah Siregar Sry Suryani W Mutiara Indah Sari.

Visit our informational website: promptstudy.infopromptstudy.info us: or

Cell Biology & Cancer Unit Objective 1 Cancer types, incidence, pre-disposition, and risk factors Biomedical Technology.

Lynch Syndrome or Hereditary Non-Polyposis Colorectal Cancer (HNPCC)

Kyle Salsbery Genetic Counselor

Biomedical Technology

‘ACHIEVING WORLD CLASS CANCER OUTCOMES’

Family Tree Presentation

Genetic Testing Result Means. Before Genetic Testing  The result of genetic testing can be life changing.  It is important for patients and their families.

Who in the room would offer BRCA1/2 testing to this patient Who in the room would offer BRCA1/2 testing to this patient? How might the medical management.

Genetic Testing.

Graduate School of Medical Science & Egineering

PTEN Tumor Suppressor Extraordinaire

Genetic testing and screening are two different things.

Biomedical Technology

Specific Tumor Suppressor Genes

Breast Cancer BRCA testing protocol

Breast cancer BRCA testing protocol

Presentation transcript:

Uterine Cancer Endometrial (or uterine) cancer will account for 50,000 new cases and 8200 deaths in the United States in Two genetic disorders are associated with abnormal genes – Lynch syndrome and Cowden syndrome. Lynch syndrome accounts for 2% of all uterine cancers. In Lynch syndrome the risk of uterine cancer by age 70 is 50% (range 25% to 60%) compared to 2.7% for the general population. Average age of onset is 48 Like colon cancer patients with Lynch, women with Lynch and endometrial cancer have a better prognosis.

The second disorder is Cowden Syndrome. This is a mutation in the pTEN protein, which is one of the proteins responsible for regulating cell growth. Clinically, Cowden is not one finding but a constellation of factors that increase the chance of finding this altered gene. The following is the consensus criteria for the diagnosis:

To check for Cowden syndrome, you will be assessed to see if you meet criteria for a research study offered by the Cleveland Clinic. If you meet criteria, the Cleveland Clinic has a grant to look for pTEN mutations. The test is also available through reference labs.

Beyond these two syndromes there are other conditions that can increase your chances for uterine cancer. Call for an appointment so we can discuss your family history and whether you might be a carrier of one of these genes.