1. Graduate School of Medical Science & Egineering
What Is the PTEN?
Graduate School of Medical Science & Engineering
Graduate School of Medical Science & Egineering
Hanbyul, Kim
15:18:36
4번째

2. INDEX 1. Brief History of PTEN 2 . PTEN function
: Modulator of cell signaling ; growth, migration and apoptosis
3 . PTEN regulating mechanism
4 . Translational study (Clinical trials) : Rapamycin
5 . Recent study (Hot topic) : cancer metabolism & PTEN
6 . Summary
15:18:36

3. PTEN was discovered independently by two groups in 1997
Ramon Parson
Tavtigian SV
15:18:36

4. Schematic of the PTEN protein
PTEN (phosphatase and tensin homolog)
MMAC1 (mutated in multiple advanced cancer 1)
15:18:36

5. Major enzymatic function of PTEN
15:18:36

6. Canonical PTEN-PI3K-mTOR pathway
15:18:36

7. Somatic inactivation of PTEN occurs in a wide range of tumors
glioblastoma
Endometrial Cancer
Prostate Cancer
melanoma
15:18:36

8. Germline mutation of PTEN causes multiple harmartoma disorders
Cowden disease
Bannayan-Zonana syndrome
Proteus syndrome
15:18:36

9. PTEN is regulated at different levels.
15:18:36

10. PTEN : Modulator of cell signaling, growth, migration and apoptosis
15:18:36

11. PTEN : Modulator of cell signaling, growth, migration and apoptosis
15:18:36

12. PTEN : Modulator of cell signaling, growth, migration and apoptosis
15:18:36

13. PTEN is essential for embryonic development and tumour suppression
15:18:36

14. PTEN is essential for embryonic development and tumour suppression
15:18:36

15. Selected drug targeting the PI3K pathway that is activated in tumors deficient for PTEN
15:18:36

16. Recent Study (Hot topic)
15:18:36

17. 1. PTEN is one of the most frequently mutated tumor suppressors
Summary
1. PTEN is one of the most frequently mutated tumor suppressors
in human cancer
2. PTEN have been identified in the regulation of many normal cell
processes, including growth, adhesion, migration, invasion and
apoptosis.
3. PTEN is essential for embryonic development and
tumour suppression
4. Many agent have been developed that can inhibit PI3K and/or mTOR
signaling in tumor cell
15:18:36

18. END
THANK YOU
15:18:36