VIRAL STRUCTURE & TYPES ETHAN WRIGHT, RACHEL SYLVIA, EMILY MCGREEN

STRUCTURE Three components: -Capsid (capsomeres) -Genome (3-5 average, - over 100 expressed proteins) -Envelope (some have this) -Viral Envelope -viral glycoproteins - derived from host membrane Mimivirus! – size of small becteria -Bring questions as to evolutionary history

TYPES OF VIRUSES -Capsid structure - rod-shaped -polyhedral -or more complex Host Range Bacteriophage – viruses that infect bacteria

I’D LIKE TO INFECT YOU WITH MY DNA ;) ;) Viral Reproduction

TWO MECHANISMS OF REPLICATION BY PHAGES: LYTIC AND LYSOGENIC CYCLES

© 2011 Pearson Education, Inc. Animation: Phage T4 Lytic Cycle Right-click slide / select “Play”

© 2011 Pearson Education, Inc. Animation: Phage Lambda Lysogenic and Lytic Cycles Right-click slide / select “Play”

EVOLUTION Replication occurs in host cell Uses host cell’s organelles to synthesis progeny viruses

Glycoprotein Reverse transcriptase HIV Viral envelope Capsid RNA (two identical strands) HOST CELL Viral RNA Reverse transcriptase RNA-DNA hybrid DNA NUCLEUS Provirus Chromosomal DNA RNA genome for the next viral generation mRNA New virus HIV Membrane of white blood cell 0.25  m HIV entering a cell New HIV leaving a cell FIGURE 19.8

PATHOGENICS KARA HEATHERTON, JAKE ROST, GRIFFIN SCHROETER

Symptoms Severity of the virus Vaccine Treatment VIRAL DISEASE IN ANIMALS & PLANTS

Epidemic Pandemic 3 factors  1. mutations  2. spread from humans  3. spread from animals EMERGING VIRUSES

VIROIDS AND PRIONS

I’D LIKE TO INFECT YOU WITH MY DNA ;) ;) Viral Reproduction

TWO MECHANISMS OF REPLICATION BY PHAGES: LYTIC AND LYSOGENIC CYCLES

© 2011 Pearson Education, Inc. Animation: Phage T4 Lytic Cycle Right-click slide / select “Play”

© 2011 Pearson Education, Inc. Animation: Phage Lambda Lysogenic and Lytic Cycles Right-click slide / select “Play”

EVOLUTION Replication occurs in host cell Uses host cell’s organelles to synthesis progeny viruses

Glycoprotein Reverse transcriptase HIV Viral envelope Capsid RNA (two identical strands) HOST CELL Viral RNA Reverse transcriptase RNA-DNA hybrid DNA NUCLEUS Provirus Chromosomal DNA RNA genome for the next viral generation mRNA New virus HIV Membrane of white blood cell 0.25  m HIV entering a cell New HIV leaving a cell FIGURE 19.8

PATHOLOGY KARA HEATHERTON, JAKE ROST, GRIFFIN SCHROETER

Symptoms Severity of the virus Vaccine Treatment VIRAL DISEASE IN ANIMALS & PLANTS

Epidemic Pandemic 3 factors  1. mutations  2. spread from humans  3. spread from animals EMERGING VIRUSES

VIROIDS AND PRIONS