Karyotyping Biology Miss Schwipperty
Questions How many chromosomes come from your Father? How many chromosomes come from your Mother? What are chromosome pairs 1-22 called? What is chromosome pair 23 called?
Karyotype A photograph of an organism’s chromosomes -homologous chromosomes are grouped together Based on size, banding pattern, and location of centromere
Karyotype Helpful in finding chromosomal abnormalities Can NOT tell if baby has blue eyes! Are there too many or too few chromosomes? Are chromosomes missing sections?
Normal Female
Normal Male
Karyotype Changes in chromosome number occur during NONDISJUNCTION Chromosome pairs fail to separate during meiosis
Monosomy Fertilized zygote has only ONE copy of a particular chromosome
Trisomy Fertilized zygote has THREE copies of a particular chromosome
Monosomy and trisomy are often fatal to the embryo, but not always …
Trisomy 21: Downs Syndrome
Nondisjunction of the sex chromosomes …
Klinefelter’s Syndrome XXY = male; unusually small testes, sterile. Breast enlargement and other feminine body characteristics. Normal intelligence.
Jacobs Syndrome XYY = male - Tall with heavy acne - Speech & reading XYY = male - Tall with heavy acne - Speech & reading problems problems - Aggressive tendency??? - Fertile
Triple X Syndrome - XXX = female - Fertile with normal intelligence
Turner Syndrome the ONLY viable monosomy Do NOT undergo puberty XO = female ; sterile
Amniocentesis Usually performed during 2 nd trimester (week 14-17) Small amount amniotic fluid is tested for chromosomal abnormalities
Can you name to following disorders?