Human embryonic stem cells Human induced pluripotent stem cells Yamanaka S. et al. Cell 2007 Thomson J. et al. Science 2007.

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Presentation transcript:

Human embryonic stem cells

Human induced pluripotent stem cells Yamanaka S. et al. Cell 2007 Thomson J. et al. Science 2007

Proteomic comparison 14 days of analysis 15,091 phosphorylation sites 7,962 unique proteins

Multiplexed enrichment analysis

Chromatin Modifying Proteins Note reversed scale

Protein-protein interactions

Becker, KA. et al Journal of Cellular Physiology 2007

Reprogramming networks

Cyclin-dependent kinase 2

mRNA up, protein down

Kinase Analysis