An Overview of Dementia

The Earliest Case Hospital for Mentally Ill & Epileptics (Frankfurt )

Case Presentation 76 yo black male ~6months of troubles getting lost, difficulties managing money/medications Son states he tend to repeat himself He is aware and concerned about his memory MMSE 23/30

Case Presentation What labs are indicated? Neuroimaging? What is the most likely diagnosis? What is the prognosis?

Grossberg GT J Gerontol Med Sci 2003 Dementia is a Growing Problem 4 million cases of Alzheimer’s disease today 18 million worldwide By million cases of AD in U.S. Up to 50% of persons > 85yrs are demented Majority of long-term care residents suffer from dementia

Myths About Dementia Dementia is an inevitable part of aging Dementia is synonymous with Alzheimer’s disease Dementia cannot have an acute onset Dementia is an untreatable disorder Dementia cannot be accurately diagnosed without autopsy

Myths About Dementia Dementia is a “global” disorder of cognitive function Dementia is only a memory problem Dementia always impairs insight into cognitive deficits Dementia is only a cognitive & not a behavioral disorder

Dementia in Primary Care Primary care physicians see large numbers of patients with dementia Dementia can be accurately diagnosed and managed in a primary care setting General medical health is closely related to late life cognitive function

Barriers to Assessment of Dementia Failure to recognize symptoms of dementia Negative attitudes towards treatment and therapeutic nihilism Limited time Lack of confidence in establishing a particular diagnosis

Potential Benefits of Establishing a Diagnosis Planning for the future Identify patients at high risk of complications Early treatment may delay progression Refer to community based resources

Normal Cognitive Aging Decreased speed and efficiency of learning Difficulty inhibiting irrelevant information Troubles with “working memory” No true language dysfunction No more rapid forgetting when controlling for initial learning

Cognitive Review of Systems Troubles finding words, coming up with names Difficulty understanding conversations Getting lost Troubles recognizing people or objects Repeating conversations Difficulty managing medications, appointments, finances Personality changes, withdrawal, apathy

Clues to Presence of Dementia Troubles managing medications Difficulty providing detail in medical interview Repetitive questions New onset personality or mood changes Family members expressing concerns over memory or behavior Episodes of delirium after surgery or during hospitalization

Definition of Dementia Acquired disorder of memory and at least one other cognitive domain (language, visuospatial function, executive functions) Occurs in the setting of a clear sensorium Affects occupational and social functioning

J Am Geriar Soc 2004 Maryland Assisted Living Study Dementia prevalence ~67% with AD accounting for 50% Mean MMSE score of 14.5 Family/caregivers failed to identify dementia in ~20% of demented residents 28 % had not undergone a complete evaluation Only 50% received treatment

Epidemiology of Dementia Over 100 illnesses cause dementia Majority of cases are Alzheimer’s disease Non-AD dementias account for ~50% –Vascular dementia ~15% –Dementia with lewy bodies ~20% –Frontotemporal dementias ~5% –Other (NPH, syphillis, HIV, Parkinson’s disease dementia, vasculitis, etc.)

Dementia Prevalence by Type

Delirium vs. Dementia Delirium Acute onset Marked fluctuations Poor attention Changes in alertness Marked circadian disturbances Dementia Gradual Less fluctuation Generally attentive Generally alert Mild circadian disturbance

Cortical vs. Subcortical Dementia Cortical Normal speed of thought Aphasia Amnesia Visuospatial dysfunction Normal gait Paratonic rigidity Subcortical Bradyphrenia No aphasia “Forgetful”, poor recall Visuospatial dysfunction Impaired gait, posture Movement pathology

DSM-IV Diagnostic Criteria for AD Development of cognitive deficits manifested by both  impaired memory  aphasia, apraxia, agnosia, disturbed executive function Significantly impaired social, occupational function Gradual onset, continuing decline Not due to CNS or other physical conditions Not due to an Axis I disorder (e.g., schizophrenia)

Risk Factors for AD Age Family history CV risk factors (hypertension, diabetes, elevated homocysteine, cholesterol?) Late onset depression Delirium Fewer years of education Head injury

Possible Protective Factors NSAIDs Statins Antihypertensives Antioxidants Exercise

Routine Evaluation of Dementia Complete blood count Thyroid function test (TSH) Vitamin B-12 level/folate Complete metabolic panel (BUN/Cr, glucose, calcium, LAEs, electrolytes) Neuroimaging should be done at least once –Non-contrast CT –MRI brain without contrast

Brief Mental Status Examination MMSE Clock-drawing tests Blessed-dementia rating scale Mini-cog 7-minute screen

Comprehensive Mental Status Examination Attention Language Memory Visuospatial/perceptual functions Executive functions Praxis Calculations

Key Physical Exam Points Look for extrapyramidal dysfunction Asymmetric findings Pyramidal tract findings and pathologic reflexes Gait dysfunction Coordination Sensation

Not Routinely Recommended Erythrocyte sedimentation rate RPR Lumbar puncture HIV Serial neuroimaging Functional neuroimaging (PET, SPECT) Full neuropsychological testing

Mild AD 2001 to 2004

Early AD Poor short term memory Difficulty learning and retaining new information Mild word-finding difficulties Naming problems Problems with organization, and complex planning

Moderate AD Worsening memory problems Remote memory becomes involved More obvious language problems Visuospatial and topographical orientation Getting lost, unable to find way back home Behavioral changes (delusions, aggression, irritability, anxiety)

Severe AD Aphasia (unable to comprehend language other than simple commands) Agnosia (difficulty recognizing objects, people, etc.) Apraxia (inability to perform skilled movements despite intact motor/sensory skills)

Strategy for Treating AD Slow or delay progression Correct exacerbating factors/conditions Treat and prevent concomitant CVD Treat behavioral and psychiatric problems Treat functional problems

Current Treatments Acetylcholinesterase inhibitors –Donepezil (Aricept) –Rivastigmine (Exelon) –Galantamine (Reminyl) N-methyl-D-aspartate inhibitors –Memantine (Namenda) –May be used in conjunction with CHEIs

Acetylcholinesterase Inhibitors Approved for mild-moderate AD Aricept just approved for severe AD Start as early as possible Continue as long as possible Use maximum dose tolerated Failure to respond to one does not preclude response to another

Acetylcholinesterase inhibitors Most AD patients decline by 3-4 points on MMSE per year Treatment generally may delay progression by ~ 6 months Behavior and function may improve in addition to cognition

Reinforce Expectations of Persistent Treatment ChEI treatment is the standard of care for mild to moderate AD Improvement, stabilization, or slowed decline represent treatment success –Evaluate treatment response in the context of progressive decline –Inform patient and caregiver that stabilization is desirable –Use follow-up visits to reinforce realistic expectations Aricept has proven benefits on cognitive, functional, and behavioral symptoms ChEI = cholinesterase inhibitor.

How to Improve AD Management Detect and diagnose early Provide early and persistent treatment Evaluate treatment response in the face of progressive decline Manage physician, patient, and caregiver expectations of disease course and treatment response

Summary Dementia is a major public health problem Dementia is under recognized in all settings Dementia is a disorder of cognition, behavior and function Effective treatments exist that may improve or help preserve all 3 domains