NIH Paylines (May 2010) Institute New Invs. NCI15%20% NIAID11% 16% NHLBI 16/12% --- NIDDK17%19% NINDS 13-16% (~22% overall) NIAMS15%20% NIMH up to 20% NIA 8%13%

How Did NIA Get to 8%? NCI NIDDK NIA NHLBI NIMH Payline (%) Year The payline for NIA was similar to other major Institutes in However, the payline at NIA has declined constantly over the past 2 years.

Changes in NIA Funding and Grant Applications Since 2005 Total Budget RPG Budget # of Applications 2005 $1.05B $706M 1, * $1.08B $715M 2,113 Change +2.9% +1.3% +22% From NIA Database * Data does not include ARRA funds or applications

Changes in Funding (Direct Costs) of RPGs Based on Size of Grant Size of Grant Direct Costs($/Yr) < $300K $300K - $1.5M $1.5M - $3M >$3M % 41.0% 12.5% 2.9% % 41.9% 20.9% 13.4% Change -46% NC* +67%** +362%*** From NIA Database * Although the total percent funding was similar for grants in this range, the percent of funds for P01 grants decreased 50% and funding for U01 grants increased over 5-fold ** Increase due equally to increased funding of large R01s, P01s, and U01s *** Increase only due to increased funding of U01 grants.

Changes in Funding (Direct Costs) of RPGs Based On Type of Grant Type of Grant R01, etc.* P01 U % 23.7% 2.6% % 21.3% Change -24%** -10%*** +719% # From NIA Database * R01, R03, R15, R21, R33, R34, R37 ** Grants under $300K decreased 45% (from $308M to $169M) while grants over $300K increased 7% from $212M to $226M. *** The cost of P01 grants under $1.5 M per year decreased 45% (from $92M to $50M while the cost of P01s over $1.5 M per year increased 34% (from $76M to $103M). #The total dollars for U01s increased from $18M to $167M (827% increase in total dollars).

The total funds for NIA (and funds for RPGs) has changed very little between 2005 and 2009 (less than 3%) while applications have increased over 20%.  Smaller grants, e.g., R01s and P01s, have decreased ~45% between 2005 and 2009 while funding of larger grants (R01s, P01s, and U01s) has increased.  Trends in RPG funding Funding of U01s have increased 7- to 8- fold between 2005 and 

Future Projection on NIA Payline NCI NIDDK NIA NHLBI NIMH Payline (%) No Change Decrease Increase ? The major questions are: (1) will the NIA payline return to the level of the other major Institutes and (2) if so, when will this happen.

Disclaimers: 1.Data obtained from public sources, the Biology of Aging staff did not provide any of the information. 2.Any information from NIA Council came from the public hearing session of the Council. From: Arlan Richardson, Ph.D. The University of Texas Health Science Center at San Antonio