1. Discovery: Stem Cell Biology Proposed Actions Continue infrastructure award program Characterize cell lines Stimulate more research on basic biology Train investigators to culture and use stem cells

3. stemcelltaskforce.nih.gov NIH Director’s Stem Cell Task Force Resource Access Career Pathways Peer Review Tools and Technologies Research Community Outreach NIH Director and Advisory Committee to the Director NIH Stem Cell Research Implementation Committee Institute and Center Directors NIH Extramural and Intramural Research Programs Task Force Working Groups Coordination of NIH Stem Cell Research Program Strategies

4. NIH hESC Awards 7 Infrastructure Awards $ 5,547,159 9 Investigator-initiated Awards$11,394,400 40 Administrative Supplements $ 3,931,790 2 Pilot & Feasibility Projects $ 476,447 1 Postdoctoral Fellowship $ 48,148 December 13, 2002

5. Infrastructure Awards (R24) Awards to organizations with entries on NIH hESC Registry available for Federal funds to develop into distribution-quality cell lines Two year period of support Seven awards for total of $5,547,159 Led to development of nine hESC lines ready for shipment with more to come in near future PA recently re-issued with receipt dates in February and May 2003

6. Program Announcements (PAs) Short-term Courses in Human Embryonic Stem Cell Culture Techniques –T15 Mechanism (Continuing Education Training) –Supported by 11 NIH Institutes –Issued February 2002 –$1M direct costs committed (FY2002) –Three-year support ($150,000/year direct maximum) –Receipt dates (April 23, 2002 and October 23, 2002) –Reissued for receipt date (Jan-Mar 2003)

7. Program Announcements Career Enhancement Award for Stem Cell Research (K18) and Career Development Award (K08, K23) Release: March 1, 2002; Expire: June 1, 2005 NIDDK, NIAAA, NINR, NIAID, NHLBI Mid-career investigators, 6-24 month salary and $50,000 direct/year Training to use stem cells in research –grants.nih.gov/grants/guide/pa-files/PAR-02-069.html

8. Requests for Applications (RFAs) Exploratory Center Grants for hESC Research (NIGMS) (Letter of intent 2/13/03; receipt date 3/13/03) Multi-investigator teams to conduct research using hESCs Infrastructure, growth and maintenance, biochemical/ molecular markers for hESCs, unique properties of hESCs, pilot studies P20 Exploratory Center Grant, leading to P50 application $2M in 2003, funding 2-3 P20 grant applications for up to 3 years at $500,000 direct/year

9. Additional PAs/RFAs Innovative Concepts and Approaches to Developing Functional Tissues and Organs for Heart, Vascular, Lung, and Blood Applications (R21) (NHLBI) Plasticity of Human Stem Cells in the Nervous System (R01) (NINDS, NIA, NIMH, NHLBI) Basic and Applied Stem Cell Research for Arthritis and Musculoskeletal Diseases (RO1) (NIAMS) Stem Cells in Development/Repair of Orofacial Structures (NIDCR)

10. Additional PAs/RFAs Basic Research on Mesenchymal Cell Biology (NIA, NHLBI) Comprehensive Programs in Beta Cell Biology (NIDDK) Cellular Repair Studies of the Auditory and Vestibular System (NIDCD) Research on Stem Cell Biology and Cell-based Therapies for Heart, Lung, Blood, and Sleep Disorders (NHLBI) Stem Cell Research for Alcohol-related Disorders (NIAAA)

11. NIH Intramural Research Six laboratories at NIH are currently using hESC in their research Expanding interest as cell line availability becomes more straightforward Considering development of stem cell characterization unit within Intramural Research Program

12. NIH Stem Cell Web Sites Stem Cell Information –www.nih.gov/news/stemcell Human Embryonic Stem Cell Registry –escr.nih.gov Stem Cell Task Force –stemcelltaskforce.nih.gov E-mail Contact for Stem Cell Registry –stemcell@mail.nih.gov