细胞内的调控网络种类及特点 罗霞 柯永培 潘明 2002 年 12 月 6 日

细胞内的调控网络 新陈代谢调控网络 转录调控网络 信号传导调控网络

新陈代谢调控网络

新陈代谢调控网络的特点 ※ Any two nodes in the system can be connected by relatively short paths along existing links. ※ ※ There are many highly integrated small modules, which group into a few larger modules, which in turn can be integrated into even larger modules. ※ ※ The apparent conservation of the network diameter. ※

返回 A: scale-free network B: manifestly modular network C: hierarchical network

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转录调控网络 转录调控网络 ◆ network motifs ◆ transcriptional regulatory networks Saccharomyces cerevisiae Escherichia coli in

Significance of network motifs: Network motifs: The simplest units of used transcriptional regulatory network architecture. They provide specific regulatory capacities such as positive and negative feedback loops. They can be used as building blocks to construct large network structures.

酿酒酵母转录调控网络的特点 six regulatory network motifs ＊ Autoregulation ＊ Multi-Component Loop ＊ Feedforward Loop ＊ Single-Input Motif ＊ Multi-Input Motif ＊ Regulator Chain

大肠杆菌转录调控网络的特点 Feedforward loop Single input module(SIM) Dense overlapping regulons(DOR)

X: general transcription factor Y: specific transcription factor Z: effector operon(s) Feedforward loop coherent incoherent

信号传导调控网络 regulation by protein-protein interactions protein phosphorylation regulation of enzymatic activity production of second messengers cell surface signal transduction systems Ca 2+ signaling pathways tyrosine kinase pathways other protein kinase cascades intracellular protease cascades in apoptosis mechanisms pathways

信号传导调控网络的特点 ＊ Extended signal duration. ＊ Activation of feedback loops. Activation of feedback loops. ＊ Definition of threshold stimulation for biological effects. Definition of threshold stimulation for biological effects. ＊ Multiple signal outputs.

Ca 2+ 、 DAG DAG+AA( arachidonic acid) cPLA2MAPK 激活激活 PKC 返回

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