Patched is a 12 pass transmembrane receptor: Patched is the receptor for the key signaling protein Hedgehog.

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Presentation transcript:

Patched is a 12 pass transmembrane receptor:

Patched is the receptor for the key signaling protein Hedgehog

In mammals Hedgehog signaling occurs through the cilium

PTCH is key at many places in normal development Johnson, Milenkovic, et. Al. (Molecular Cell) In Flies: Anterior posterior patterning in embryos Wing Pattern In Humans: Somites Neural tube Brain Development Holoprosencephaly Heart Development Many other areas of the body (

SHH Pathway is key in Nervous system patterning in Vertebrates

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( Basal Cell Carcinoma affects the basal stem cells in the skin

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Vismodegib is another HH/PTCH1/SMO pathway inhibitor Typical treatment for BCCs is surgery Inhibitor called Vismodegib shows promising results in clinical trials

Works Cited "Alkaloid." Wikipedia. Wikimedia Foundation, 04 Jan Web. 01 Apr "Basal Cell Carcinoma." UF&Shands, The University of Florida Academic Health Center. N.p., n.d. Web. 30 Mar Gailani, Mae R. “Developmental Genes and Cancer: Role of Patched in Basal Cell Carcinoma of the Skin”. Journal of National Cancer Institute. Vol. 89, No. 15, August 6, 1997 Gustafsson, Marcus K. “Myf is a direct target of long-range Shh signaling and Gli regulation for muscle specification”. Genes and Development. Vol 16. November 1, "Holoprosencephaly." Wikipedia. Wikimedia Foundation, 29 Mar Web. 30 Mar Johnson RL., “In vivo functions of the patched protein”. Molecular Cell. Vol. 6, Issue 2, August 1, 2000 Nature.com. Nature Publishing Group, n.d. Web. 01 Apr "PTCH1." - Patched 1. N.p., n.d. Web. 30 Mar Ribes, Vanessa; James Briscoe. “Establishing and Interpreting Graded Sonic Hedgehog Signaling during Vertebrate Neural Tube Patterning”. Cold Spring Harbor Perspectives in Biology (2009). July 15, Robbins, David J., “The Hedgehog Signal Transduction Network”. Cell Biology. Vol. 5, Issue 246, October 16, 2011 Tang, Jean Y., et al. “Inhibiting the Hedgehog Pathway in Patients with the Basal-Cell Nevus Syndrome”. The New England Journal of Medicine. Vol 366. June 7, "What Are Basal and Squamous Cell Skin Cancers?" What Are Basal and Squamous Cell Skin Cancers? N.p., n.d. Web. 30 Mar