Information in Biology. Outline What is synthetic biology? Biological Clocks The “Repressilator” Signal transduction The “Diverter”

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Presentation transcript:

Information in Biology

Outline What is synthetic biology? Biological Clocks The “Repressilator” Signal transduction The “Diverter”

Outline What is synthetic biology? Biological Clocks The “Repressilator” Signal transduction The “Diverter”

Outline What is synthetic biology? Biological Clocks The “Repressilator” Signal transduction The “Diverter”

What is synthetic biology?  The design and construction of new biological parts, devices, and systems  The “Repressilator”  The re-design of existing, natural biological systems for useful purposes.  The “Diverter”

Outline What is synthetic biology? Biological Clocks The “Repressilator” Signal transduction The “Diverter”

Biological - Clocks  Three questions 1. How does it work 2. How does it synchronize 3. How does it translate to activity

Biological - Clocks

Outline What is synthetic biology? Biological Clocks The “Repressilator” Signal transduction The “Diverter”

The “Repressilator”

Repressilator  oscillations are favored by Strong promoters Efficient ribosome-binding sites Tight transcriptional repression Comparable protein and mRNA decay rates

Repressilator

Outline What is synthetic biology? Biological Clocks The “Repressilator” Signal transduction The “Diverter”

Signal Transduction

The Yeast system  Scaffold proteins  Mediating recruitment  Improve efficiency of signal transfer.  Facilitate interactions among different signal pathways  Control localization of signal proteins within a cell.

Outline What is synthetic biology? Biological Clocks The “Repressilator” Signal transduction The “Diverter”

The Pre-Diverter

The Diverter

Diverter results

Summary What is synthetic biology?  The design and construction of new biological parts, devices, and systems The Repressilator  The re-design of existing, natural biological systems for useful purposes. The Diverter

Signal transduction movies signal transduction  TRnFdI4 TRnFdI4 signal transduction  m/MBWeb/mb1/part2/signals.htm#anim at2