S. Goto1, J. Zhu2, L. Lisheng2, BH. Oh3, D. Wojdyla4, M. Hanna5, J. Horowitz6, L. Wallentin7, D. Xavier8, JH. Alexander4 (1) Tokai University School of.

Slides:

Advertisements

Similar presentations

PAREXEL begrüsst die deutschsprachige CDISC-UG Berlin,

Advertisements

Programme: 145 sessions & social events

Are we where the Jews are? LCJE – CEO conference, France May 18-22, 2009 Rolf G. Heitmann.

1 Accenture Agenda  Our Mission  Our Company  Company Services  Company Structure  Company Revenues  Employees  Our Clients  Our People.

ISO 31000, a risk management standard for decision-makers

Efficacy and safety of apixaban compared with warfarin at different levels of INR control for stroke prevention in atrial fibrillation.

Total Student Mobility between Outgoing Exchange Students by Host Country Moreover, 8: Czech Rep., Hungary 6: Japan, Russia 5: Norway 4: Singapore.

Users and Uses of IPUMS International Data Presented by Dr. Miriam King.

Beginning of a Strong relationship through TRAVEL INSURANCE PRODUCTS TRAVEL INSURANCE.

Twenty Questions Subject: Flags of the world Twenty Questions

Kenneth W. Mahaffey Daniel M. Wojdyla Stefan K. James Hugo A. Katus Steen Husted Gabriel Steg Christopher P. Cannon Richard C. Becker Claes Held Nardev.

© Lloyd’s Regional Watch Content Guide CLICK ANY BOX AMERICAS IMEA EUROPE ASIA PACIFIC.

RECMA Research Company evaluating the Media Agency Industry

Modernisation and secularisation quantified Marion Burkimsher Observatoire des Religions, University of Lausanne, Switzerland Marion Burkimsher Observatoire.

Global Variations in the 1-year Rates of Death and Stroke in Patients Presenting to the Emergency Department with Atrial Fibrillation Results from the.

Supply Risk Monitoring Supply Risk Monitoring (SRM) Draws on global operational network, and analytical engine –SRM website provides quick overview.

Windows Azure Inside a Datacenter  video 

Results of the 1 st Phase of the International GLORIA-AF Registry Program: Regional Treatment Differences Before the Era of Novel Anticoagulants MV Huisman,

1 Announcing … Global broadband subscribers to 30 June 2005 Total: 176 million 115 million * 65% * choose DSL.

Capitalist. Main Points In a capitalist or free-market country, people can own their own businesses and property. People can also buy services for private.

The Global Economic Environment The Coming Boom Wealthy Industrial Countries Developing Countries East Asia South Asia Latin America

Perfection in Automation

France Belgium Italy South Africa USA UK Australia New Zealand Israel Austria Norway Ireland Den- mark Finland Spain Canada Nether- lands Sweden Switzer-

Chapter 15 Development of the profession of O&M around the world.

Global Impact Awards Argentina Australia Austria Belgium Brazil Canada China France Germany Greece Hungary India Indonesia Israel Italy Japan Korea Malaysia.

Chapter 27 Chapter 27 Geographic Variability in Hip and Vertebral Fractures Copyright © 2013 Elsevier Inc. All rights reserved.

2015 ANNUAL DATA REPORT V OLUME 2: E ND -S TAGE R ENAL D ISEASE Chapter 13: International Comparisons.

Worldwide Group Specialists Introducing Costa Del Sol - Andalucia March 31 to April 8, 2016.

The United States The Economy. What is GDP ? Gross Domestic Product (GDP): The total market (or dollar) value of all final goods and services produced.

Overview of the Singapore Economy 2000 –GDP = US$92 bil (0.9% of US economy) –Per Capita GNP = US$24,700 (ranked 19th in the world)

Hello Around the World ! Europe France Everyone in France speaks French. Bonjour (BONE-zhure) Example Slide.

The (IMG) Systems for Comparative Analysis of Microbial Genomes & Metagenomes: N America: 1,180 Europe: 386 Asia: 235 Africa: 6 Oceania: 81 S America:

Shinya Goto,1 Jun Zhu,2 Liu Lisheng,2 Byung-Hee Oh,3 Daniel M. Wojdyla,4 Michael Hanna,5 John D. Horowitz,6 Lars Wallentin,7 Denis Xavier,8 John H. Alexander4.

“45 Flags” – Soc. St. Project by 6B Can you identify all the flags? Which one is your flag?

Who we are 2© 2015 INC Research, LLC Therapeutically specialized teams The complete range of Phase I to IV clinical development services Helping you develop.

2016 Global Manufacturing Competitiveness Index. 2Deloitte and US Council on Competitiveness I 2016 Global Manufacturing Competitiveness IndexCopyright.

Bed Linen Markets in the World to 2017 Bharat Book Bureau.

Global Printing Ink Market to Market Size, Growth, and Forecasts in Over 70 Countries “This comprehensive publication enables readers the critical.

Global Aluminium Pipe and Tube Market to 2018 (Market Size, Growth, and Forecasts in Nearly 60 Countries) Published Date: Jul-2014 Reports and Intelligence.

STUDY ABROAD TRENDS April 2009 Sara Dumont Director Abroad at AU American University.

IEC System of Conformity Assessment Schemes for Electrotechnical Equipment and Components.

What is a volunteer? Why are they important? Think! Pair! Share!

IEC System of Conformity Assessment Schemes for Electrotechnical Equipment and Components.

IEC System of Conformity Assessment Schemes for Electrotechnical Equipment and Components.

Introduction DSV is a global supplier of transport and logistics services. DSV has offices in more than 70 countries all over the world and an international.

Atos in a nutshell CEO: Thierry Breton, since 2009 $12bn annual revenue employees in 72 countries Among Top 7 IT Service Providers WW #2 in ITO.

Date of download: 6/28/2016 Copyright © The American College of Cardiology. All rights reserved. From: Efficacy and Safety of Enoxaparin Versus Unfractionated.

Assessment Of The Global Construction Market And Growth Trends In Global Economy, 2021 Published: Apr 2017 Single User PDF: US$ 4950 Order this report.

Global overview partner work permits* Sept ‘16

Certification CS-100/ CSE-200 /CSC-1

Where Are You From? Famous People.

Six Sigma Total Error Percent Process Sigma 1,000, ,000 10% 2.78

Japan-USA Synergies: Academic View

Snapshot of Global PV Markets

Presented by World Sleep Society

Economic Exports.

Electrification Products

Non-vitamin K antagonist oral anticoagulants (NOACs) for stroke prevention in Asian patients with atrial fibrillation: Time for a reappraisal Gregory.

HCM Pivot Grids and Analytics Garland Gaskins, Interpublic Group

Locations where Black Panther was released in the theaters in 2018.

Citi Virtual Card Accounts – Continued Global Expansion

Status of EQ-5D-5L Valuation Using Standardized Valuation Methodology

Sourcing. Costs. HARDWARE + SERVICE

Infographics on Electromobility (November 2018)

IBM's Geographical Structure and where IBM Global Financing has clients IBM Global Financing, the world's largest IT captive financier, has a total asset.

Infographics on Electromobility. APRIL 2019.

Global Commercial Agriculture

Digital transformation of tax administration

Presenter Disclosure Information

Electrification business

Presentation transcript:

S. Goto1, J. Zhu2, L. Lisheng2, BH. Oh3, D. Wojdyla4, M. Hanna5, J. Horowitz6, L. Wallentin7, D. Xavier8, JH. Alexander4 (1) Tokai University School of Medicine, Isehara, Japan (2) Fuwai Hospital, Beijing, China, People's Republic of (3) Seoul National University Hospital, Seoul, Korea, Republic of (4) Duke Clinical Research Institute, Duke University Medical Center, Durham, United States of America (5) Bristol-Myers Squibb, Princeton, United States of America (6) University of Adelaide, Adelaide, Australia (7) Uppsala University, UCR-Uppsala Clinical Research Center, Uppsala, Sweden (8) St. John's Research Institute, Bangolore, India Efficacy and Safety of Apixaban Compared with Warfarin for Stroke Prevention in Atrial Fibrillation in East Asia with Atrial Fibrillation

Global Collaboration 39 countries, 1034 sites, 18,201 patients Canada: 1057 United States: 3433 Mexico: 609 Finland: 26 Denmark: 339 Hungary: 455 Netherlands: 309 Ukraine: 956 Sweden: 217 Norway: 90 U.K.: 434 Belgium: 194 France: 35 Spain: 230 Austria: 34 Italy: 178 Israel: 344 Poland: 314 Czech Rep: 165 Chile: 258 Peru: 213 Colombia: 111 Brazil: 700 Argentina: 1561 South Africa: 89 Russia: 1800 China: 843 India: 601 South Korea: 310 Taiwan: 57 Philippines: 205 Malaysia: 126 Singapore: 40 Australia: 322 Germany: 854 Japan: 336 Romania: 274 Turkey: 6 Hong Kong: 76 Bristol-Myers Squibb and Pfizer 1,993 patients were recruited from East Asian countries including China (n=843), Japan (n=336), South Korea (n=310), Philippines(n=205), Malaysia (n=126), Hong Kong (n=76) and Singapore (n=40)

Primary Efficacy Endpoint

Primary Safety Endpoint

Conclusion- East Asia vs Non East Asia The ARISTOTLE trial enrolled over 1900 patients from East Asian countries. These patients were of lower body weight and tended to have poorer INR control with warfarin. Despite similar CHADS2 scores, the overall rate of stroke was higher in East Asian than non-East Asian patients. Apixaban had consistent benefits when compared with warfarin on stroke or systemic embolism in East Asian and non-East Asian patients. A tendency toward a greater reduction in bleeding was seen with apixaban compared with warfarin in East Asian compared with non- East Asian patients. Rates of intracranial bleeding on warfarin were higher in East Asian than non-East Asian patients. These data support that apixaban is an attractive alternative to warfarin among East Asian as well as non-East Asian patients with nonvalvular AF.