Trichloroethylene (TCE) Update Waste Site Cleanup Advisory Committee Meeting January 24, 2013.

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Presentation transcript:

Trichloroethylene (TCE) Update Waste Site Cleanup Advisory Committee Meeting January 24, 2013

Trichloroethylene (TCE) Update Timeline on TCE 1989 EPA withdrew TCE values from IRIS 2001 EPA released draft TCE Health Assessment 2002 EPA SAB reviewed the draft Health Assessment 2006 NAS released report and recommendations 2009 EPA issued draft Health Assessment for TCE 2011: USEPA released its Final Assessment for TCE on IRIS.

Basis for New Values RfC2 µg/m 3 (2 x mg/m 3 ) Immune system effects Fetal heart malformations RfD0.5 µg/kg/day (5 x mg/kg-day) Fetal heart malformations Immune system effects Developmental immune system effects Oral Slope Factor 5.0 x per mg/kg-day Kidney cancer Liver cancer non-Hodgkin Lymphoma “Carcinogenic to humans via ingestion “ Unit Risk (Inhalation) 4.0 x per µg/m 3 Kidney cancer Liver cancer non-Hodgkin Lymphoma “Carcinogenic to humans via inhalation”

Effects of Toxicity Value Changes on Method 1 and 3 (Residential; Risk Drivers – cancer or noncancer) Current (Old Value) New IRIS ValueHealth Endpoint (new IRIS value) Method 1 No Significant Risk (Risk Driver) GW-2 = 30 μg/L (Based on air background of 4.5 μg/m 3 ) Risk-based indoor air conc. = 1.4 μg/m 3 (Cancer risk of 1 x from 30 year exposure) GW-2 = 5 μg/L (Based on air background of 0.8 μg/m 3 ) Risk-based indoor air conc. = 0.4 μg/m 3 Chronic Exposure Non-cancer Risk (HQ= 0.2) Fetal heart developmental effects and immune effects for all receptors Method 3 No Significant Risk (Risk Driver) 14 µg/m 3 (Cancer risk of 1 x from 30 year exposure) 2 µg/m 3 Chronic Exposure Non-cancer Risk (HQ=1) Fetal heart developmental effects and immune effects for all receptors

MCP Imminent Hazard The conditions at the disposal site pose an Imminent Hazard when: 1. ”a Hazard Index equal to 1.0 for OHM that have the potential to cause serious effects (including but not limited to lethal, developmental, or neurological effects) following short-term exposures; and 2. a Hazard Index equal to 10 for all other oil or hazardous materials.”

Effect of Toxicity Value Change on Imminent Hazard Method 3 Short Forms Current (Old Value) New IRIS Value for Interim Approach Health Endpoint (new IRIS value) Imminent Hazard (Risk Driver) 85 µg/m 3 (Cancer Risk of 1 x from 5-year exposure) 2 µg/m 3 Sub-chronic exposure Non-cancer Risk (HQ=1) For sensitive groups: pregnant women and women of childbearing age 20 µg/m 3 Sub-chronic exposure Non-cancer Risk (HQ=10) For all other people Fetal (heart) developmental effects for sensitive groups and immune effects for all receptors Immune effects

Other Agencies Agency Comment US EPA NCEAGuidance not yet publishedPromised last Fall US EPA OSWER Region X Removal Action Levels (RALs) HI = 1Pregnant women/women of childbearing age US EPA OSWER Region IX (RALs) HI = 3Pregnant women/women of childbearing age ATSDRHI = 2 (MA case)Pregnant women/women of childbearing age New Jersey DEPHI= 2 (Rapid Action Limits)Pregnant women/women of childbearing age

Workplan for TCE by ORS Review EPA, NAS and SAB documents Meet with DEP/DPH Health Effects Advisory Committee Focus on short term developmental effects: – Review the evidence for fetal developmental effects – Evaluate approaches for addressing short term exposures BWSC and ORS will also discuss MCP risk management criteria (HQ limits)