BIOmem Glucose sensor Une belle histoire…. - Concept -- Clark (1956) - Concept -- Clark (1956) - Enzyme electrode -- Lyons and Clark (1962) - Enzyme.

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Presentation transcript:

BIOmem Glucose sensor Une belle histoire…

- Concept -- Clark (1956) - Concept -- Clark (1956) - Enzyme electrode -- Lyons and Clark (1962) - Enzyme electrode -- Lyons and Clark (1962) HISTORY OF BIOSENSORS

Oxygen sensor: [O 2 ] current GlucoseGluconic acid OxygenHydrogen Peroxide O 2 H 2 O 2 Glucose Oxidase

- Concept -- Lyons and Clark (1956) - Concept -- Lyons and Clark (1956) - Enzyme electrode -- Lyons and Clark (1962) - Enzyme electrode -- Lyons and Clark (1962) - Glucose Analyser -- Yellow Springs Instr. Co. (1973) - Glucose Analyser -- Yellow Springs Instr. Co. (1973) HISTORY OF BIOSENSORS

Peroxide sensor: [H 2 O 2 ] current GlucoseGluconic acid OxygenHydrogen Peroxide O 2 H 2 O 2 Glucose Oxidase

1975 : YSI 23A Blood Glucose Analyzer First whole blood glucose analyzer (YSI, USA) 1982 : YSI 2300 STAT Plus Glucose & Lactate Analyzer Glucose analyseur commercialisé par YELLOW SPRINGS Instr. Co.

- Concept -- Lyons and Clark (1956) - Concept -- Lyons and Clark (1956) - Enzyme electrode -- Lyons and Clark (1962) - Enzyme electrode -- Lyons and Clark (1962) - Glucose Analyser -- Yellow Springs Instr. Co. (1973) - Glucose Analyser -- Yellow Springs Instr. Co. (1973) - Enzyme Electrode – MediSense Inc. (1987) - Enzyme Electrode – MediSense Inc. (1987) HISTORY OF BIOSENSORS

Mediator (ferrocene)e - current GlucoseGluconic acid OxygenHydrogen Peroxide O 2 H 2 O 2 Glucose Oxidase

1983 : Glucose capteur avec médiateur électrochimique GlucoseGluconic acid GOD-FADGOD-FADH 2 FerriciniumFerrocene 1 e-

THE MEDISENSE* EXACTECH™ GLUCOSE biocapteur pour le sang *MediSense is now owned by Abbott Since 1996 (867 million $) WalMart ReliOn™ (MediSense ™)

2005 : GlucoWatch G2 (Cygnus Inc., USA) : based on electroosmosis and electrochemical measurement of interstitial fluid Evolution récente : système non invasif

GLUCOSE SENSOR Market opportunity -Diabetus Biology -Glucose oxidase Instrumentation -portable Electronics -data processing Chemistry -polymers -electrode materials -mediators

Glucose sensors Others THE BIOSENSOR MARKET The growing global problem of diabetes Statistics (estimate) People with diabetes (million) % in developed countries Female/male ratio Source: World Health Organisation.(Newman & Turner, 2005)