About IntraOp Medical Co-founded in 1993 by Dr. Donald Goer Makers of the Mobetron, the first fully portable, self- shielding electron beam linear accelerator The Mobetron is used to administer intraoperative electron-beam radiation therapy (IOERT) 10 hospitals in North America have installed the Mobetron; 23 are in use worldwide

IOERT and Breast Cancer IOERT gaining traction as cutting-edge treatment for breast cancer patients around the world Dr. Umberto Veronesi, Director of the European Institute of Oncology in Milan, Italy and world-renowned breast surgeon, has pioneered the use of IOERT for this purpose

Dr. Umberto Veronesi – Background Dr. Veronesi has been a pioneering breast surgeon for nearly 40 years His clinical trials established breast conserving therapy – rather than mastectomy – as the standard of care for breast cancer patients His mission is to shift the breast cancer treatment paradigm from “maximum tolerable treatment” to “minimum effective treatment”

Dr. Umberto Veronesi – Current Study Dr. Veronesi’s research studies using IOERT for breast cancer began in 1999 and more than 3200 Italian women have taken part in it Dr. Veronesi’s current study seeks to determine whether women who receive breast-conserving surgery can have their post-surgical radiation reduced from the standard 6 weeks of daily radiation treatments to a 2-minute treatment of IOERT given at the time of surgery More than 1300 women have participated in this latest randomized trial

Study Results Dr. Veronesi presented the first findings of his randomized trial at the recent ISIORT conference in Madrid, Spain (June 2008) Patients were divided into two groups that received one of two types of treatment: –Breast conserving surgery and a single dose of IOERT –Breast conserving surgery and traditional 6 weeks of post- operative radiation therapy Dr. Veronesi’s study reported that, to date, women who received a single dose of IOERT had identical control, survival and comestic results as those who underwent the standard 6 week radiation regimen

The Bombshell A single dose of IOERT may be equivalent in outcome to 6 weeks of post-operative radiation therapy. Many women can be successfully treated with IOERT rather than undergo a long course of radiation therapy.

What are the Benefits of Single-Dose IOERT? Single-dose radiation treatment means single-day treatment –Patients get back to their lives more quickly –Patients are spared the expense, time, and trouble of 6 weeks of daily radiation –Patients can have oncoplastic reconstruction at the time of surgery rather than have to return many months later for a second surgery IOERT gives doctors an edge on treating cancer –Doctors can apply radiation to the exact area that requires treatment, avoiding healthy tissue –Doctors don’t have to wait until a patient heals to deliver life-saving radiation

Where Can Breast Cancer Patients Receive Single-Dose IOERT Treatment? Single-dose IOERT treatment for breast cancer is widely available in Europe and Asia There is only one facility in the United States that offers single-dose IOERT breast cancer treatment The University of North Carolina Lineberger Comprehensive Cancer Center uses IntraOp’s Mobetron to administer single- dose IOERT to breast cancer patients

Why Aren’t More American Hospitals Offering IOERT Treatment? Cost –American hospitals do not want to pay for additional devices that they are not certain they will quickly “break even” on –American hospitals are not certain insurance companies will cover the treatment – sufficiently, or at all Knowledge –Many American doctors have been waiting for the results of the Veronesi randomized trials before considering adopting this technique Availability –IOERT equipment is not yet widely available in the United States

Available for Comment As manufacturers of the only machine in the United States capable of delivering single-dose IOERT to breast cancer patients, IntraOp Medical is poised to answer questions and comment on Dr. Veronesi’s recent findings. IntraOp Medical’s founder, Dr. Donald Goer, as well as representatives from the University of North Carolina Lineberger Comprehensive Cancer Center, are available for comment. A patient who recently received single- dose IOERT from the Mobetron at UNC is also available for comment.

Spokespeople IntraOp Medical –Dr. Donald Goer, Founder and Chief Scientist –John Powers, CEO The University of North Carolina Lineberger Comprehensive Cancer Center –Dr. Joel Tepper, Professor and Chair of Radiation Oncology –Dr. David Ollila, Associate Professor and Surgical Director for the Multidisciplinary Breast program and Multidisciplinary Melanoma Program Patient –Arleen Sharwell, single-dose IOERT breast cancer patient at the University of North Carolina Lineberger Comprehensive Cancer Center

Additional Resources I Biographies –Dr. Donald Goer –Dr. Joel Tepper –Dr. David Ollila Case Study –Arleen Sharwell Video –Interview with Dr. Umberto Veronesi from the European Society of Surgical Oncology meeting (2006) –Mobetron in use at the Ohio State University Comprehensive Cancer Center

Additional Resources II Other documents –Single-dose treatment brochure –IOERT breast cancer brochure –Nagoya University in Japan announces single-dose IOERT treatment program for breast cancer patients

For More Information Media Contact Regina Nisita Affect Strategies x145 Corporate Contact Wink Jones IntraOp Medical