XIX International AIDS Conference 25 July 2012 Lee Hall, MD, PhD Chief, Parasitology & International Programs Branch Division of Microbiology & Infectious Diseases

Interactions Between NTDs & HIV Are Bidirectional 2 Neglected Tropical Diseases HIV

Some Potential Effects of NTD-HIV Coinfections  Changes in Disease Progression or Clinical Manifestations  Changes in Transmissibility  Changes in Susceptibility  Impacts on Diagnostic Sensitivity or Specificity 3

Some Potential Effects of NTD-HIV Coinfections: Research Considerations  Qualitative vs. Quantitative Changes?  What Mechanisms Are Responsible for the Changes?  Are the Changes Reversible? Preventable?  What Would Be Considered a Meaningful Effect?  Do We Have Adequate Tools to Reverse or Prevent Changes?  What Alternatives Are Available to Achieve the Desired Changes? 4

Research Opportunities: Funding Mechanisms  Investigator-Initiated Research Projects –R01 Research Project Grant –R03 Small Grant –R21 Exploratory/Developmental Grant Clinical Trials –R34 Clinical Trial Planning Grant –U01 Clinical Trial Implementation Grant –mR01 Milestone-driven Clinical Trial Implementation Grant  Solicited Research Activities See NIAID Home Page ( for Funding Opportunity Announcements  Research Resources 5

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Research Opportunities: Examples of Research Resources  Filariasis Research Reagent Resource Center (FR3)  Schistosomiasis Resource Center  International Collaborative Network for the Study of Human Helminth Co-infections  HIV/AIDS Clinical Trials Networks 7

For More Information:  NIAID Home Page 8

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