MRI of the locus coeruleus and substantia nigra

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Presentation transcript:

MRI of the locus coeruleus and substantia nigra Dr Timothy Rittman Academic Foundation Year 2

Substantia nigra Locus coeruleus

Imaging of SN

Sasaki et al

Effect of MT and SPIR

Magnetisation transfer Neuromelanin Macromolecules = short T2* Off resonance radiofrequency pulse Transfer of energy from macromolecules water ?iron SPIR presaturation pulse hidden MT effect

Method T1 MRI Repetition time 757ms Echo time 9.1ms Voxel size = 0.47x0.47x2.75mm3 SPIR 7 healthy volunteers MT not possible due to SAR limits

Results - Substantia nigra

Results - Locus coeruleus

Conclusion The substantia nigra and locus coeruleus are visible using T1 weighted imaging with SPIR Most likely due to an MT effect Sequence is sensitive to neuromelanin Specificity remains to be tested

Thanks to… Prof Auer All in Academic Radiology All at Sir Peter Mansfield Magnetic Resonance Centre Prof Mahida and Prof Hawkey