1.Biography 2. Project 3. Success 4. References

Name: Sid Altman Birth date: May 7, 1939 Birth place: Montreal, Quebec Residence: New Haven, Connecticut Title Sterling: Professor of Biology, Chair of Biology, Professor of Chemistry, Dean at Yale University Office: Biology Department, Yale University, Connecticut, USA Status: Working Degrees: BSc (Physics) Massachusetts Institute of Technology, 1960 PhD (Biophysics) University of Colorado, 1967 Awards: Nobel Prize in Chemistry, 1989 Rosenstiel Award for Basic Biomedical Research, 1989 National Institutes of Health Merit Award, 1989 Yale Science and Engineering Association Award, 1990

In Crick and Brenner’s lab, in about 1970, Altman was investigating part of this complex process. He discovered an enzyme called “RNase P” that chops a little “tail” off the end of an intermediate molecule of RNA called “precursor-tRNA.” In recent years Dr. Altman and his research team at Yale University have applied their knowledge of RNA molecular biology to develop a method to inhibit the expression of any gene in any organism. They have patented a technique that stops the expression of virus genes in human tissue culture cells. Some day they expect it will work in vivo— in people.

Discovered catalytic RNA, for which he won the Nobel Prize in 1989

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