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Engineering at the interface of RNA- protein complexes for solving difficult problems in biology and medicine Contreras-Martin Research Group Laboratory.

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Presentation on theme: "Engineering at the interface of RNA- protein complexes for solving difficult problems in biology and medicine Contreras-Martin Research Group Laboratory."— Presentation transcript:

1 Engineering at the interface of RNA- protein complexes for solving difficult problems in biology and medicine Contreras-Martin Research Group Laboratory of Molecular Engineering University of Texas at Austin Department of Chemical Engineering Austin, TX 78712 USA Graduate Recruiting Weekend- 2.26.2011

2 Contreras-Martin Research Lab Graduate Recruiting Weekend- 2.26.2011 What does Artic foxes and drug-resistant bacteria have in common? Summer Environment

3 A challenge in fighting pathogenic bacteria Disease-causing microbes that have become resistant to antibiotic drug therapy are an increasing public health problem. ~ 70 percent of the bacteria that cause infections in hospitals are resistant to at least one of the drugs most commonly used for treatment. Contreras-Martin Research Lab Graduate Recruiting Weekend- 2.26.2011

4 RNA-protein complexes: key anti-bacterial targets “Possibly the most pregnant recent development in molecular biology is the realization that the beginnings of life are closely associated with the interactions of proteins and nucleic acids” — Florence O. BellFlorence O. Bell Example: Bacterial ribosome critical for survival (Nobel Prize, 2009) Contreras-Martin Research Lab Graduate Recruiting Weekend- 2.26.2011 Chloramphenicol, Erythromycin, Neomycin, Gentamicin Tetracycline, Thiostrepton, Spiramycin…

5 Molecular aspects of RNA-based recognition Challenge: Understanding how to discriminate among all cellular molecules for recognition of a specific target RNA E. coli cytoplasm ~6mg/ml RNA Structural and chemical features of RNAs that allow them to be recognized as drug targets? How do these interactions rearrange with environmental changes? How do they recognize their natural targets? Contreras-Martin Research Lab Graduate Recruiting Weekend- 2.26.2011

6 Graduate Recruiting Weekend- 2.26.2011 Engineering RNAs and RNA-targeting molecules with novel functionality Can we exploit these sophisticated recognition methods for the design and development of new biotechnologically and therapeutically relevant RNAs?

7 Graduate Recruiting Weekend- 2.26.2011 Understanding and Engineering RNAs Approach 1: Gain mechanistic insights about RNA-protein recognition Approach 3: Design of new RNA molecules and RNA-targeting compounds with novel functionality Approach 2: Exploit features of intermolecular interactions for new biotechnological tools Modeling Techniques Engineer molecular tools to study: Structure Particle physics Chemical composition reconfigure cellular behavior Controllable RNA elements RNA-based sensors Predict resistance Random mutagenesis Rational design De novo design

8 Contact Information Dr. Lydia Contreras-Martin Office: 5.410 CPE Email: lcontrer@che.utexas.edulcontrer@che.utexas.edu Phone: 512-471-2453 Graduate Recruiting Weekend- 2.26.2011

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