Polio Eradication  Although the number of endemic countries is at an all-time low in 2002, the actual number of cases was approximately four times higher than last year, mostly because of a greatly increased number of cases in India and Nigeria.  Nine states within three countries (India, Nigeria and Pakistan) are responsible for over 90 percent of cases reported in  In India, 1005 cases were confirmed in 2002, representing 85 percent of new polio cases worldwide.  The northern state of Uttar Pradesh, with a population of 173 million, accounted for 66 percent of cases in the world.  Surveillance data show the remaining polio burden is caused by a failure to vaccinate at-risk children both in routine and supplementary immunization activities.  Unless the WHO, the polio eradication partners, and the national governments of the affected countries urgently address managerial, operational, and political barriers, polio transmission can be expected to continue throughout 2003 and beyond.

CountryContributions to Date (US$m) Projections (US$m) Kananaskis Pledges (US$m) Total Contributions, Pledges, Projections (US$m) UK Canada US[1][1] Japan[2][2] Germany650 Italy30 3 France00 0 Russia00 0 EC270 Polio Eradication Global Polio Eradication Initiative - G8 contributions All figures US$ millions As at Jan 2003

Measles Containment  Measles causes approximately 800,000 deaths each year  Largest single cause of child vaccine-preventable deaths.  Fifth-leading cause of death worldwide among children aged <5 years and causes more deaths in this age group than either HIV/AIDS or TB.  Since 1997, all confirmed measles cases in the United States (totaling 540 cases) have been the result of documented or presumed importations from measles-endemic countries.  Measles vaccine is safe, effective, and cheap ($0.30 per dose including needle, syringe, and disposal).  U.S. sponsoring resolution on measles at World Health Assembly this year.

Global Alliance for Vaccines and Immunization  Public-Private Partnership begun with $750 million donation from the Bill and Melinda Gates Foundation; total resources now above $1 billion  HHS/CDC sits on the GAVI Board, along with USAID  Provides countries with resources to strengthen routine immunization services; pays for vaccines against hepatitis B, Hib disease and yellow fever, and safe injection materials; and provides a small one-time investment to help support introduction activities.  GAVI immunization programs are up and running in more than 60 out of 74 eligible countries around the developing world.  Approximately two-thirds of funding used to purchase vaccines and supplies and the rest is for support for capacity development and infrastructure  10.5 million children so far vaccinated against Hepatitis B

GAVI Milestones By 2005, 80% of developing countries will have routine immunization coverage of at least 80% in all districts. By 2002, 80% of all countries with adequate delivery systems will have introduced hepatitis B vaccine. By 2007, all countries. By 2005, 50% of poorest countries with high disease burdens and adequate delivery systems will have introduced Hib vaccine. By 2005, the world will be certified polio-free. By 2005, the vaccine efficacy and burden of disease will be known for all regions for rotavirus and pneumococcal vaccine, and mechanisms identified to make the vaccines available to the poorest countries.

Global Health Security Action Group  Established in November 2001 by Health Ministers of U.S., Canada, United Kingdom, France, Italy, Japan, Germany, and Mexico. European Commission and the World Health Organization also participate.  Promotes cooperation on emergency preparedness and response against threats of bioterrorism, including sharing of plans and strategies.  Cooperative work on vaccine purchasing and stockpiling  Technical working group on influenza pandemic, chaired by the US and the UK, to address existing R&D gaps and needs

International HIV Vaccine Research and Clinical Trials

Global Fund to Fight AIDS, Tuberculosis and Malaria  Round One: 58 grants in 40 countries;  $616 million/two years  Round Two: 98 grants in some of the same countries plus 45 new ones;  $860 million/two years  Major investments in health care systems, including laboratory capacity, training of personnel, clinical care, support for families and orphans, prevention education