Host-Parasite Relationship Normal Flora Pathogens Infections Opportunistic pathogens.

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Presentation transcript:

Host-Parasite Relationship Normal Flora Pathogens Infections Opportunistic pathogens

Skin Flora 180 species Streptococcus Staphylococcus Propionibacterium Body Odor Acne

Oral Cavity Flora Plaque Anaerobes Biofilms Dental Caries Streptococcus mutans, sobrinus Sucrose

Tongue

Intestinal Tract Stomach – pH Helicobacter pylori Small Intestine Enterococci, Lactobacilli

Large intestine cells/gm Bacteroides Enterobacteria Escherichia coli Enterococcus

Large Intestine Flora Methanogens Food passage 24 hrs Excrete /day Probiotics Fecal transplant

Respiratory Tract Staphylococcus aureus Streptococcus pneumoniae S. pyogenes Corynebacterium diphtheriae Carrier

Opportunistic Pathogens E. coli Virulence Invasiveness Toxicity Lactobacillus acidophilus Urogenital Tract

Adherence Specific Adherence Capsule Slime Layer Glycocalyx Fimbriae Pili - longer

Invasiveness Colonization Factor Antigen Invasion Colonization Iron- Siderophore Bacteremia vs. Septicemia

Enzymes & Toxins Coagulase Collagenase Exotoxins Cytolytic Toxins Hemolysins, Leukocidins Diphtheria Toxin Botulism Toxin Tetanus Toxin Tetanus

Enterotoxin Cholera toxin Endotoxin – Pyrogen LD 50 Virulence Factors Attenuated Strains Other Toxins Pyrogen free Products

Virulence Factors

Nonspecific Host Defense Natural Resistance Age Stress Diet Anatomical Defenses Skin, Stomach, Tears

Compromised Hosts Inflammation Fever Nosocomial Infections

Host-Parasite Word List Normal Flora Pathogens Infection Skin Flora Staphylococcus, Propionibacterium Oral Cavity Flora Plaque Streptococcus spp Dental Caries Streptococcus mutans Intestinal Tract Stomach – pH2 Helicobacter pylori Small Intestine Enterococci, Lactobacilli Large Intestine cells/gram

Host-Parasite Word List cells/gram Bacteroides, Enterobacteria, Escherichia coli, Enterococcus Respiratory Tract Staphylococcus aureus, Streptococcus pneumoniae, S. pyogenes, Corynebacterium diphtheriae Carrier Urogenital Tract Opportunistic Pathogens Virulence Invasiveness, Toxicity Specific Adherence

Host-Parasite Word List 3 Capsule, Glycocalyx, Slime Layer Fimbriae, Pili Colonization Factor Antigen Invasion Colonization Iron – Siderophore Bacteremia – Septicemia Enzymes & Toxins Coagulase, Collagenase Exotoxins Cytolytic Toxins Hemolysins, Leukocidins

Host-Parasite Word List 4 Diphtheria Toxin Botulism Toxin Tetanus Toxin Enterotoxin Cholera Toxin Endotoxin LD 50 Attenuated Nonspecific Host Defenses Natural Resistance Age, Stress, Diet Anatomical Defenses Skin, Stomach, Tears

Host-Parasite Word List 5 Compromised Host Inflammation Fever